SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		4 / 7 ILE A 385
PRO A 344
PHE A 441
ASN A 444
 None
 0.84A 1oniG-3q6mA:
undetectable
1oniI-3q6mA:
undetectable		 1oniG-3q6mA:
15.55
1oniI-3q6mA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		3 / 3 TYR A 493
ARG A 456
GLN A 532
 None
 0.99A 1tw4A-3q6mA:
undetectable		 1tw4A-3q6mA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		4 / 8 ILE A 449
TYR A 438
CYH A 529
TYR A 465
 None
 1.15A 2xz5A-3q6mA:
undetectable
2xz5C-3q6mA:
undetectable		 2xz5A-3q6mA:
18.36
2xz5C-3q6mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		4 / 8 ILE A 449
TYR A 438
CYH A 529
TYR A 465
 None
 1.16A 2xz5C-3q6mA:
undetectable
2xz5D-3q6mA:
undetectable		 2xz5C-3q6mA:
18.36
2xz5D-3q6mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 12 VAL A 600
CYH A 598
CYH A 597
MET A 575
ILE A 642
 None
 1.48A 3g8iA-3q6mA:
undetectable		 3g8iA-3q6mA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 338
GLU A 336
ARG A 367
 None
 0.88A 4mwvA-3q6mA:
undetectable		 4mwvA-3q6mA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		3 / 3 ASN A 504
ALA A 503
ARG A 512
 None
 0.53A 5cvtB-3q6mA:
3.0		 5cvtB-3q6mA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		3 / 3 LEU A 533
ILE A 449
TYR A 438
 None
 0.65A 5uunB-3q6mA:
undetectable		 5uunB-3q6mA:
19.74