SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 VAL A  93
VAL A 103
TRP A 101
None
0.83A 1av2A-3q6tA:
undetectable
1av2B-3q6tA:
undetectable
1av2A-3q6tA:
3.40
1av2B-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 7 TYR A 110
THR A  87
SER A 120
TYR A 118
None
1.29A 1eiiA-3q6tA:
0.9
1eiiA-3q6tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 VAL A  93
VAL A 103
TRP A 101
None
0.95A 1w5uA-3q6tA:
undetectable
1w5uB-3q6tA:
undetectable
1w5uA-3q6tA:
3.40
1w5uB-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 TRP A 302
ARG A 271
PHE A 291
None
1.22A 1zeaH-3q6tA:
undetectable
1zeaL-3q6tA:
undetectable
1zeaH-3q6tA:
19.94
1zeaL-3q6tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 THR A 200
ILE A 278
GLY A 243
ILE A 222
ALA A 220
None
0.87A 2fk8A-3q6tA:
undetectable
2fk8A-3q6tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 VAL A 103
TRP A 101
VAL A  93
None
0.92A 2izqC-3q6tA:
undetectable
2izqD-3q6tA:
undetectable
2izqC-3q6tA:
3.40
2izqD-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 ILE A 222
ALA A 242
GLY A 243
ARG A 180
GLY A 155
None
1.07A 2qe6B-3q6tA:
undetectable
2qe6B-3q6tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 LEU A 362
SER A 341
ASN A 342
LEU A  42
TYR A   6
None
1.27A 3fsuA-3q6tA:
undetectable
3fsuA-3q6tA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 11 GLY A 155
PHE A 178
ALA A 158
ALA A 238
ALA A 182
None
1.09A 3g88A-3q6tA:
undetectable
3g88A-3q6tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 11 GLY A 155
PHE A 178
ALA A 158
ALA A 238
ALA A 182
None
1.08A 3g88B-3q6tA:
undetectable
3g88B-3q6tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 GLY A 155
PHE A 178
ALA A 158
ALA A 238
ALA A 182
None
1.07A 3g8bB-3q6tA:
undetectable
3g8bB-3q6tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 ILE A 185
VAL A 196
LEU A 183
ILE A 225
LEU A 227
None
1.06A 3w67D-3q6tA:
undetectable
3w67D-3q6tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 6 GLU A  57
TYR A 135
VAL A 138
PHE A  77
None
0.98A 4a97E-3q6tA:
undetectable
4a97E-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 7 GLU A  57
TYR A 135
VAL A 138
PHE A  77
None
1.06A 4a97H-3q6tA:
undetectable
4a97H-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 ASP A 332
ARG A 364
ASP A 283
None
0.81A 4fp9A-3q6tA:
undetectable
4fp9A-3q6tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 ASP A 332
ARG A 364
ASP A 283
None
0.85A 4fp9F-3q6tA:
undetectable
4fp9F-3q6tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 5 GLY A 243
SER A 244
ALA A 203
PHE A 178
None
1.05A 4m93B-3q6tA:
undetectable
4m93C-3q6tA:
undetectable
4m93B-3q6tA:
21.41
4m93C-3q6tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 6 ARG A 236
ASP A  96
VAL A 139
ALA A 127
None
1.01A 4nkxA-3q6tA:
undetectable
4nkxA-3q6tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 5 TYR A 153
ASN A 177
GLU A 109
TYR A  90
None
1.45A 4twdC-3q6tA:
0.0
4twdD-3q6tA:
0.0
4twdC-3q6tA:
23.02
4twdD-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 6 TYR A 153
ASN A 177
GLU A 109
TYR A  90
None
1.45A 4twdG-3q6tA:
undetectable
4twdH-3q6tA:
undetectable
4twdG-3q6tA:
23.02
4twdH-3q6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 GLU A  57
ALA A  56
PHE A  41
None
0.65A 4v1fA-3q6tA:
undetectable
4v1fA-3q6tA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
3 / 3 GLU A  57
ALA A  56
PHE A  41
None
0.62A 4v1fC-3q6tA:
undetectable
4v1fC-3q6tA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 5 ASP A 332
TYR A   6
LEU A 362
THR A  60
None
1.10A 4wozF-3q6tA:
undetectable
4wozH-3q6tA:
undetectable
4wozF-3q6tA:
19.85
4wozH-3q6tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 GLY A 155
ILE A 222
LEU A 183
ILE A 225
GLY A 326
None
0.96A 5d4uC-3q6tA:
undetectable
5d4uC-3q6tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 GLY A 155
ILE A 222
LEU A 183
ILE A 225
GLY A 326
None
0.92A 5d4uD-3q6tA:
undetectable
5d4uD-3q6tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 9 GLN A 298
GLY A 326
SER A 341
ILE A 329
ALA A 279
None
1.38A 5entC-3q6tA:
undetectable
5entC-3q6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 ILE A 225
GLY A 156
VAL A 103
ALA A 158
ALA A 238
None
1.06A 5n0oB-3q6tA:
undetectable
5n0oB-3q6tA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
4 / 6 ASN A  75
ALA A  56
VAL A  58
TYR A  13
None
1.22A 5umd2-3q6tA:
undetectable
5umdF-3q6tA:
undetectable
5umd2-3q6tA:
12.16
5umdF-3q6tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  29
None
1.02A 5xipB-3q6tA:
undetectable
5xipB-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  54
None
1.38A 5xipB-3q6tA:
undetectable
5xipB-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  29
None
1.06A 5xipC-3q6tA:
undetectable
5xipC-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  29
None
1.09A 5xipD-3q6tA:
undetectable
5xipD-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis)
5 / 12 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  54
None
1.42A 5xipD-3q6tA:
undetectable
5xipD-3q6tA:
21.61