SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IBG_H_OBNH1_2 (IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN) IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN))	3q6z	POLY [ADP-RIBOSE] POLYMERASE 14 (Homo sapiens)	4 / 7	SER A 838 HIS A 879 TYR A 911 LEU A 907	None	0.99A	1ibgL-3q6zA: undetectable	1ibgL-3q6zA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_B_SAMB202_0 (UPF0066 PROTEIN AF_0241)	3q6z	POLY [ADP-RIBOSE] POLYMERASE 14 (Homo sapiens)	5 / 12	ALA A 822 PRO A 883 GLY A 862 LEU A 860 SER A 904	APR A 1 (-3.3A) None None None None	1.36A	2nv4B-3q6zA: undetectable	2nv4B-3q6zA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_A_CUA601_0 (LACCASE-1)	3q6z	POLY [ADP-RIBOSE] POLYMERASE 14 (Homo sapiens)	4 / 5	HIS A 829 CYH A 849 HIS A 879 LEU A 827	None	1.47A	3qpkA-3q6zA: undetectable	3qpkA-3q6zA: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UY4_A_PAUA302_0 (PANTOTHENATE SYNTHETASE)	3q6z	POLY [ADP-RIBOSE] POLYMERASE 14 (Homo sapiens)	4 / 8	HIS A 879 VAL A 877 VAL A 818 ASP A 848	None	1.12A	3uy4A-3q6zA: undetectable	3uy4A-3q6zA: 24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0R_A_PX9A201_0 (BETA-LACTOGLOBULIN)	3q6z	POLY [ADP-RIBOSE] POLYMERASE 14 (Homo sapiens)	5 / 12	LEU A 804 LEU A 959 ILE A 957 LEU A 954 ILE A 916	None	1.06A	4y0rA-3q6zA: undetectable	4y0rA-3q6zA: 21.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IBG_H_OBNH1_2","IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN);IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN)","3q6z","POLY [ADP-RIBOSE] POLYMERASE 14","Homo sapiens",4,"SER A 838;HIS A 879;TYR A 911;LEU A 907","None","0.99A","1ibgL-3q6zA:undetectable","1ibgL-3q6zA:21.03"],["2NV4_B_SAMB202_0","UPF0066 PROTEIN AF_0241","3q6z","POLY [ADP-RIBOSE] POLYMERASE 14","Homo sapiens",5,"ALA A 822;PRO A 883;GLY A 862;LEU A 860;SER A 904","APR A   1 (-3.3A);None;None;None;None","1.36A","2nv4B-3q6zA:undetectable","2nv4B-3q6zA:20.18"],["3QPK_A_CUA601_0","LACCASE-1","3q6z","POLY [ADP-RIBOSE] POLYMERASE 14","Homo sapiens",4,"HIS A 829;CYH A 849;HIS A 879;LEU A 827","None","1.47A","3qpkA-3q6zA:undetectable","3qpkA-3q6zA:17.03"],["3UY4_A_PAUA302_0","PANTOTHENATE SYNTHETASE","3q6z","POLY [ADP-RIBOSE] POLYMERASE 14","Homo sapiens",4,"HIS A 879;VAL A 877;VAL A 818;ASP A 848","None","1.12A","3uy4A-3q6zA:undetectable","3uy4A-3q6zA:24.16"],["4Y0R_A_PX9A201_0","BETA-LACTOGLOBULIN","3q6z","POLY [ADP-RIBOSE] POLYMERASE 14","Homo sapiens",5,"LEU A 804;LEU A 959;ILE A 957;LEU A 954;ILE A 916","None","1.06A","4y0rA-3q6zA:undetectable","4y0rA-3q6zA:21.96"]]