SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 PHE B 515
TYR B 514
PHE B 128
LEU B 119
VAL B 115
 None
 1.21A 1q23C-3q75B:
undetectable		 1q23C-3q75B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 GLY B 332
GLY B 333
ILE B 485
GLY B 483
PRO B 373
 None
 0.79A 1sqfA-3q75B:
undetectable		 1sqfA-3q75B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 11 LEU B 165
LEU B 150
SER B 149
PRO B  89
VAL B  92
 None
 1.34A 2po5B-3q75B:
undetectable		 2po5B-3q75B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 THR B 498
PRO B 499
VAL B 500
ALA B 474
 None
 0.76A 2v32A-3q75B:
undetectable
2v32B-3q75B:
undetectable		 2v32A-3q75B:
16.63
2v32B-3q75B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 THR B 498
PRO B 499
VAL B 500
ALA B 474
 None
 0.76A 2v32A-3q75B:
undetectable
2v32B-3q75B:
undetectable		 2v32A-3q75B:
16.63
2v32B-3q75B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 7 PRO B 429
VAL B 432
SER B 433
ARG B 436
 None
 1.01A 2v41E-3q75B:
undetectable
2v41F-3q75B:
undetectable		 2v41E-3q75B:
16.63
2v41F-3q75B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 THR B 498
PRO B 499
VAL B 500
ALA B 474
 None
 0.76A 2v41G-3q75B:
undetectable
2v41H-3q75B:
undetectable		 2v41G-3q75B:
16.63
2v41H-3q75B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 11 SER B  73
SER B  72
ALA B  71
LEU B 415
LEU B 102
 None
 1.06A 2xn5A-3q75B:
undetectable		 2xn5A-3q75B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 7 LEU B  84
ASP B 407
TRP B  94
SER B  87
 None
 1.49A 3dzgA-3q75B:
undetectable		 3dzgA-3q75B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 11 GLN B 305
THR B 301
VAL B 302
LEU B 418
ILE B 420
 None
 1.20A 3elzB-3q75B:
undetectable		 3elzB-3q75B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 GLN B 305
THR B 301
VAL B 302
LEU B 418
ILE B 420
 None
 1.12A 3elzC-3q75B:
undetectable		 3elzC-3q75B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 ALA B 151
PHE B  93
THR B 498
LEU B 101
LEU B 504
 None
 1.05A 3k2hA-3q75B:
undetectable		 3k2hA-3q75B:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 7 GLU B 339
LEU B 475
LYS B 509
ASN B 435
 None
 1.16A 3k8mA-3q75B:
undetectable		 3k8mA-3q75B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 7 GLU B 339
LEU B 475
LYS B 509
ASN B 435
 None
 1.22A 3k8mB-3q75B:
undetectable		 3k8mB-3q75B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 11 VAL B 500
GLY B 332
ALA B 297
ASN B 275
LEU B 279
 None
 1.23A 3rc0A-3q75B:
undetectable		 3rc0A-3q75B:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 VAL B 448
VAL B 205
TYR B 173
ILE B 172
 None
 0.95A 3remA-3q75B:
undetectable		 3remA-3q75B:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 VAL B 448
VAL B 205
TYR B 173
ILE B 172
 None
 0.94A 3remB-3q75B:
undetectable		 3remB-3q75B:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 6 GLY B 313
GLY B 312
ASN B 376
ILE B  37
 None
 0.95A 4fglD-3q75B:
undetectable		 4fglD-3q75B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 GLY B 311
GLY B 313
GLN B 305
VAL B   9
LEU B  12
 None
 1.14A 4fr0A-3q75B:
undetectable		 4fr0A-3q75B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 ASP B  42
VAL B 386
ALA B 387
VAL B   9
GLY B 311
 None
 1.16A 4mm6A-3q75B:
undetectable		 4mm6A-3q75B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 9 ASP B  42
VAL B 386
ALA B 387
SER B  38
GLY B 311
 None
 1.34A 4mmeA-3q75B:
undetectable		 4mmeA-3q75B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 9 ASP B  42
VAL B 386
ALA B 387
SER B  38
GLY B 311
 None
 1.32A 4mmfA-3q75B:
undetectable		 4mmfA-3q75B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 9 ASP B  42
VAL B 386
ALA B 387
SER B  38
GLY B 311
 None
 1.35A 4mmfB-3q75B:
undetectable		 4mmfB-3q75B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 GLY B 267
GLY B 316
PHE B 314
THR B 270
GLY B 333
 None
FII  B 522 ( 4.6A)
None
None
None
 1.25A 4n48A-3q75B:
undetectable		 4n48A-3q75B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 VAL B 302
ALA B 334
PHE B 314
 None
 0.75A 4olbA-3q75B:
undetectable		 4olbA-3q75B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 PHE B 234
SER B 276
SER B 225
ASP B 183
 None
 1.31A 4qb9D-3q75B:
undetectable		 4qb9D-3q75B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 5 ILE B 494
PHE B 501
CYH B 412
HIS B  66
 None
 1.22A 4rzvA-3q75B:
undetectable		 4rzvA-3q75B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 VAL B 302
ALA B 334
PHE B 314
 None
 0.83A 4w5nA-3q75B:
undetectable		 4w5nA-3q75B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 VAL B 302
ALA B 334
PHE B 314
 None
 0.75A 4z4iA-3q75B:
undetectable		 4z4iA-3q75B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 5 ASN B 376
SER B  14
ASP B  46
GLU B 382
 None
 1.33A 4zjlA-3q75B:
0.0		 4zjlA-3q75B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 4 THR B 384
LEU B  61
HIS B  66
GLY B  60
 None
 1.22A 5gwyA-3q75B:
undetectable		 5gwyA-3q75B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 ILE B 486
GLY B 489
PHE B  41
PHE B 383
 None
3CX  B 523 (-3.3A)
None
None
 0.87A 5hieD-3q75B:
undetectable		 5hieD-3q75B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 ARG B 342
HIS B 427
ARG B 343
 None
 0.98A 5iaoC-3q75B:
undetectable		 5iaoC-3q75B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 ARG B 342
HIS B 427
ARG B 343
 None
 0.94A 5iaoF-3q75B:
undetectable		 5iaoF-3q75B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 VAL B 302
ALA B 334
PHE B 314
 None
 0.76A 5js1A-3q75B:
undetectable		 5js1A-3q75B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 SER B 146
GLY B 131
GLN B 136
VAL B  92
LEU B  91
 None
 1.07A 5kocB-3q75B:
undetectable		 5kocB-3q75B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		5 / 9 HIS B  66
GLN B 389
ASN B 492
LEU B 102
LEU B 415
 None
 1.05A 6emmA-3q75B:
0.0		 6emmA-3q75B:
10.75