SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.43A 1gtfG-3q7bA:
undetectable
1gtfH-3q7bA:
undetectable		 1gtfG-3q7bA:
18.32
1gtfH-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.91A 1hwiB-3q7bA:
undetectable		 1hwiB-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.89A 1hwiD-3q7bA:
undetectable		 1hwiD-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.89A 1hwiC-3q7bA:
undetectable		 1hwiC-3q7bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
 1.24A 1upfA-3q7bA:
undetectable		 1upfA-3q7bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
 1.17A 1upfC-3q7bA:
undetectable		 1upfC-3q7bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 LEU A 370
LEU A 365
ALA A 376
CYH A 534
LEU A 531
 None
 1.16A 3b0wA-3q7bA:
undetectable		 3b0wA-3q7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 LEU A 470
ILE A 479
ILE A 390
ALA A 530
LEU A 380
 None
 1.44A 3vw1B-3q7bA:
undetectable		 3vw1B-3q7bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 ILE A 450
VAL A 449
LEU A 373
LEU A 453
VAL A 553
 None
 1.14A 4m11C-3q7bA:
undetectable		 4m11C-3q7bA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 ILE A 450
VAL A 449
LEU A 373
LEU A 453
VAL A 553
 None
 1.10A 4m11D-3q7bA:
undetectable		 4m11D-3q7bA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.13A 4z4cA-3q7bA:
undetectable		 4z4cA-3q7bA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.18A 4z4dA-3q7bA:
undetectable		 4z4dA-3q7bA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eeuH-3q7bA:
undetectable
5eeuI-3q7bA:
undetectable		 5eeuH-3q7bA:
18.32
5eeuI-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eevD-3q7bA:
undetectable
5eevE-3q7bA:
undetectable		 5eevD-3q7bA:
18.32
5eevE-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eewD-3q7bA:
undetectable
5eewE-3q7bA:
undetectable		 5eewD-3q7bA:
18.32
5eewE-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eewH-3q7bA:
undetectable
5eewI-3q7bA:
undetectable		 5eewH-3q7bA:
18.32
5eewI-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eexD-3q7bA:
undetectable
5eexE-3q7bA:
undetectable		 5eexD-3q7bA:
18.32
5eexE-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eexH-3q7bA:
undetectable
5eexI-3q7bA:
undetectable		 5eexH-3q7bA:
18.32
5eexI-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eeyD-3q7bA:
undetectable
5eeyE-3q7bA:
undetectable		 5eeyD-3q7bA:
18.32
5eeyE-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5eezD-3q7bA:
undetectable
5eezE-3q7bA:
undetectable		 5eezD-3q7bA:
18.32
5eezE-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5ef0D-3q7bA:
undetectable
5ef0E-3q7bA:
undetectable		 5ef0D-3q7bA:
18.32
5ef0E-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5ef1D-3q7bA:
undetectable
5ef1E-3q7bA:
undetectable		 5ef1D-3q7bA:
18.32
5ef1E-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5ef2D-3q7bA:
undetectable
5ef2E-3q7bA:
undetectable		 5ef2D-3q7bA:
18.32
5ef2E-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.41A 5ef3D-3q7bA:
undetectable
5ef3E-3q7bA:
undetectable		 5ef3D-3q7bA:
18.32
5ef3E-3q7bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3q7b NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 VAL A 449
ALA A 452
LEU A 445
LEU A 365
LEU A 554
 None
 0.99A 6f5uA-3q7bA:
undetectable
6f5uB-3q7bA:
undetectable		 6f5uA-3q7bA:
12.20
6f5uB-3q7bA:
14.41