SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		4 / 6 TYR A 127
ASP A 128
VAL A 142
GLY A 112
 None
 1.28A 1ekjC-3q7pA:
2.6
1ekjD-3q7pA:
2.5		 1ekjC-3q7pA:
22.81
1ekjD-3q7pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		4 / 6 ASP A 128
VAL A 142
GLY A 112
TYR A 127
 None
 1.25A 1ekjC-3q7pA:
2.6
1ekjD-3q7pA:
2.5		 1ekjC-3q7pA:
22.81
1ekjD-3q7pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		5 / 12 GLY A 103
GLY A 101
SER A 233
GLU A 147
ALA A 106
 GNP  A 256 (-3.2A)
GNP  A 256 (-3.5A)
GNP  A 256 (-3.6A)
MG  A 257 ( 2.8A)
GNP  A 256 (-3.1A)
 1.44A 3t7sC-3q7pA:
undetectable		 3t7sC-3q7pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		4 / 6 VAL A 248
ARG A 129
VAL A  94
PHE A 111
 None
 1.43A 5addA-3q7pA:
undetectable
5addB-3q7pA:
undetectable		 5addA-3q7pA:
16.35
5addB-3q7pA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		4 / 6 VAL A 248
ARG A 129
VAL A  94
PHE A 111
 None
 1.40A 5adeA-3q7pA:
undetectable
5adeB-3q7pA:
undetectable		 5adeA-3q7pA:
16.35
5adeB-3q7pA:
16.35