SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.48A 1c9sA-3q88A:
undetectable
1c9sK-3q88A:
undetectable		 1c9sA-3q88A:
10.28
1c9sK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.47A 1c9sA-3q88A:
undetectable
1c9sB-3q88A:
undetectable		 1c9sA-3q88A:
10.28
1c9sB-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.50A 1c9sE-3q88A:
undetectable
1c9sF-3q88A:
undetectable		 1c9sE-3q88A:
10.28
1c9sF-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 LEU A 473
ALA A 158
LEU A 333
ILE A 463
ILE A 397
 None
 0.99A 1fk6A-3q88A:
undetectable		 1fk6A-3q88A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.49A 1gtfA-3q88A:
undetectable
1gtfK-3q88A:
undetectable		 1gtfA-3q88A:
10.28
1gtfK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 6 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.44A 1gtnD-3q88A:
undetectable
1gtnE-3q88A:
undetectable		 1gtnD-3q88A:
10.28
1gtnE-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 8 HIS A 185
LEU A 181
ALA A 177
LEU A 180
 None
 0.91A 1hwiD-3q88A:
undetectable		 1hwiD-3q88A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdA-3q88A:
undetectable
1utdB-3q88A:
undetectable		 1utdA-3q88A:
10.28
1utdB-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdB-3q88A:
undetectable
1utdC-3q88A:
undetectable		 1utdB-3q88A:
10.28
1utdC-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdC-3q88A:
undetectable
1utdD-3q88A:
undetectable		 1utdC-3q88A:
10.28
1utdD-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 1utdF-3q88A:
undetectable
1utdG-3q88A:
undetectable		 1utdF-3q88A:
10.28
1utdG-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.48A 1utdJ-3q88A:
undetectable
1utdK-3q88A:
undetectable		 1utdJ-3q88A:
10.28
1utdK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 1utdA-3q88A:
undetectable
1utdK-3q88A:
undetectable		 1utdA-3q88A:
10.28
1utdK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 4 GLY A 287
SER A 290
ILE A  39
HIS A  36
 None
IPA  A 605 ( 4.1A)
IPA  A 605 ( 4.6A)
IPA  A 605 (-4.3A)
 1.06A 1yajJ-3q88A:
undetectable		 1yajJ-3q88A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 SER A 173
ASP A 338
CYH A 334
 None
 1.02A 2br4E-3q88A:
undetectable		 2br4E-3q88A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 8 TYR A  40
ASP A  42
SER A  44
TYR A  43
 None
 1.19A 2bteA-3q88A:
undetectable		 2bteA-3q88A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 8 TYR A  40
ASP A  42
SER A  44
TYR A  43
 None
 1.20A 2bteD-3q88A:
undetectable		 2bteD-3q88A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 VAL A  86
ASN A 494
TRP A 499
 None
 0.89A 2y00B-3q88A:
undetectable		 2y00B-3q88A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 GLU A 215
LEU A 218
ASP A 219
 None
 0.43A 3ko0T-3q88A:
0.6		 3ko0T-3q88A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 7 GLY A 287
GLY A 474
SER A 290
LEU A 479
HIS A  36
 None
None
IPA  A 605 ( 4.1A)
None
IPA  A 605 (-4.3A)
 1.43A 3o9mA-3q88A:
undetectable		 3o9mA-3q88A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 11 VAL A 291
ALA A 288
GLY A 474
ALA A 343
TYR A 339
 None
 1.40A 3qxyB-3q88A:
undetectable
3qxyQ-3q88A:
undetectable		 3qxyB-3q88A:
20.00
3qxyQ-3q88A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 11 VAL A 291
ALA A 288
GLY A 474
TYR A 339
TYR A 262
 None
 1.40A 3qxyB-3q88A:
undetectable
3qxyQ-3q88A:
undetectable		 3qxyB-3q88A:
20.00
3qxyQ-3q88A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 VAL A 392
PHE A 394
TYR A 329
PHE A 379
ASN A 374
 None
 1.38A 3r6wA-3q88A:
3.0
3r6wB-3q88A:
2.6		 3r6wA-3q88A:
18.01
3r6wB-3q88A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 LEU A  53
TYR A  43
PHE A  41
LEU A  34
LEU A 479
 None
 1.05A 3vw1B-3q88A:
undetectable		 3vw1B-3q88A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 HIS A  88
SER A 347
GLY A 488
SER A 495
VAL A 489
 None
 1.19A 4danA-3q88A:
3.3
4danB-3q88A:
undetectable		 4danA-3q88A:
18.81
4danB-3q88A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 7 ARG A  92
SER A 236
VAL A 110
TRP A 255
 None
 1.39A 4klaA-3q88A:
undetectable		 4klaA-3q88A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 GLY A 151
MET A 154
ILE A 477
PHE A 281
LEU A 285
 None
 1.34A 4kovA-3q88A:
undetectable		 4kovA-3q88A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 8 ASN A  46
PHE A  32
SER A  33
TYR A  40
 None
 1.38A 5amiB-3q88A:
undetectable		 5amiB-3q88A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eeuA-3q88A:
undetectable
5eeuK-3q88A:
undetectable		 5eeuA-3q88A:
10.28
5eeuK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eevA-3q88A:
undetectable
5eevK-3q88A:
undetectable		 5eevA-3q88A:
10.28
5eevK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eewA-3q88A:
undetectable
5eewK-3q88A:
undetectable		 5eewA-3q88A:
10.28
5eewK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eexA-3q88A:
undetectable
5eexK-3q88A:
undetectable		 5eexA-3q88A:
10.28
5eexK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eeyA-3q88A:
undetectable
5eeyK-3q88A:
undetectable		 5eeyA-3q88A:
10.28
5eeyK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.49A 5eezJ-3q88A:
undetectable
5eezK-3q88A:
undetectable		 5eezJ-3q88A:
10.28
5eezK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eezA-3q88A:
undetectable
5eezK-3q88A:
undetectable		 5eezA-3q88A:
10.28
5eezK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 5ef0J-3q88A:
undetectable
5ef0K-3q88A:
undetectable		 5ef0J-3q88A:
10.28
5ef0K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef0A-3q88A:
undetectable
5ef0K-3q88A:
undetectable		 5ef0A-3q88A:
10.28
5ef0K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef1A-3q88A:
undetectable
5ef1K-3q88A:
undetectable		 5ef1A-3q88A:
10.28
5ef1K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.49A 5ef2J-3q88A:
undetectable
5ef2K-3q88A:
undetectable		 5ef2J-3q88A:
10.28
5ef2K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef2A-3q88A:
undetectable
5ef2K-3q88A:
undetectable		 5ef2A-3q88A:
10.28
5ef2K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 5ef3J-3q88A:
undetectable
5ef3K-3q88A:
undetectable		 5ef3J-3q88A:
10.28
5ef3K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 ILE A 477
ALA A 478
GLY A 287
GLY A 151
VAL A 155
 None
 1.15A 5i71A-3q88A:
undetectable		 5i71A-3q88A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 12 ALA A 213
SER A 235
ILE A 234
TYR A 252
MET A 270
 None
 1.14A 5igvA-3q88A:
undetectable		 5igvA-3q88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 GLY A 259
GLY A 260
GLN A 498
 None
RI2  A 601 ( 3.8A)
RI2  A 601 (-4.6A)
 0.36A 5imsA-3q88A:
4.5		 5imsA-3q88A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LYS A 136
LYS A 123
SER A 126
 None
 1.39A 5odiA-3q88A:
2.6		 5odiA-3q88A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 7 THR A  89
ILE A  69
TYR A 496
PHE A 485
 None
 0.93A 5zsfA-3q88A:
undetectable
5zsfB-3q88A:
undetectable		 5zsfA-3q88A:
9.59
5zsfB-3q88A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaE-3q88A:
undetectable		 6baaE-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaF-3q88A:
undetectable		 6baaF-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaG-3q88A:
undetectable		 6baaG-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaH-3q88A:
undetectable		 6baaH-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 LEU A 284
LEU A  91
ILE A 272
PRO A 152
SER A 267
 None
 1.48A 6dm2B-3q88A:
4.1
6dm2C-3q88A:
undetectable		 6dm2B-3q88A:
9.93
6dm2C-3q88A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 ILE A 272
PRO A 152
SER A 267
LEU A 284
LEU A  91
 None
 1.48A 6dm2A-3q88A:
undetectable
6dm2D-3q88A:
undetectable		 6dm2A-3q88A:
9.93
6dm2D-3q88A:
9.93