SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 11 LEU B 185
GLY B  40
SER B  44
LEU B 230
LEU B 226
 None
None
SO4  B 602 (-3.3A)
None
None
 1.22A 1mx1B-3q8xB:
2.1		 1mx1B-3q8xB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 10 PHE B  69
LEU B  20
LEU B 106
ILE B  64
ALA B 101
 None
 1.14A 2bxeB-3q8xB:
2.3		 2bxeB-3q8xB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 8 ARG B 158
TYR B 152
GLY B 154
THR B 242
ILE B 246
 None
 1.26A 2f9wA-3q8xB:
undetectable
2f9wB-3q8xB:
undetectable		 2f9wA-3q8xB:
22.91
2f9wB-3q8xB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
ZETA-TOXIN
(Streptococcus
pyogenes) 		4 / 6 THR A   4
VAL A   3
GLU A  12
SER B  48
 None
None
SO4  B 602 (-3.2A)
None
 1.17A 3b6rB-3q8xA:
undetectable		 3b6rB-3q8xA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
ZETA-TOXIN
(Streptococcus
pyogenes;
Streptococcus
pyogenes) 		5 / 12 TYR A   5
THR B 242
ILE B 239
ASN B 205
LEU B 230
 None
 1.20A 3q87B-3q8xA:
undetectable		 3q87B-3q8xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		4 / 8 GLN B  41
VAL B 182
VAL B 181
ARG B 206
 None
 1.16A 3uy4A-3q8xB:
2.6		 3uy4A-3q8xB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
(Streptococcus
pyogenes) 		4 / 4 MET A  76
SER A  80
LEU A  50
VAL A  21
 None
 0.86A 3vlnA-3q8xA:
3.5		 3vlnA-3q8xA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		4 / 7 GLU B  78
PHE B  76
LYS B  81
TYR B  83
 None
 1.45A 4uciB-3q8xB:
undetectable		 4uciB-3q8xB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 11 THR B 118
GLY B 117
ASP B  65
GLU A  12
THR B  68
 None
None
None
SO4  B 602 (-3.2A)
None
 1.42A 4xt7A-3q8xB:
undetectable		 4xt7A-3q8xB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 10 PHE B  69
LEU B 106
ILE B  64
SER B 104
ALA B 101
 None
 1.39A 4z69I-3q8xB:
2.9		 4z69I-3q8xB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
ZETA-TOXIN
(Streptococcus
pyogenes) 		4 / 7 VAL A   3
LEU B 113
PHE B  36
LEU B  38
 None
 1.09A 6aycA-3q8xA:
undetectable		 6aycA-3q8xA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3q8x ZETA-TOXIN
(Streptococcus
pyogenes) 		5 / 12 LEU B 203
LEU B 226
GLY B  39
GLY B  40
GLY B  43
 None
None
None
None
SO4  B 602 (-3.3A)
 1.05A 6ce2B-3q8xB:
undetectable		 6ce2B-3q8xB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM
ZETA-TOXIN
(Streptococcus
pyogenes;
Streptococcus
pyogenes) 		3 / 3 PHE B  76
ARG B 171
ALA A  19
 None
 0.98A 6ecfB-3q8xB:
2.8		 6ecfB-3q8xB:
23.19