SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		5 / 12 PRO A  10
GLY A 106
ASN A 112
SER A  67
GLY A 110
 None
None
ADP  A 158 (-2.2A)
None
ADP  A 158 (-3.5A)
 1.19A 1ffyA-3q8yA:
undetectable		 1ffyA-3q8yA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 5 PHE A 131
LEU A  32
PHE A   5
SER A  84
 None
 1.36A 1wrkB-3q8yA:
undetectable		 1wrkB-3q8yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		5 / 10 GLU A  76
GLY A  77
LEU A  30
ARG A 143
TYR A 139
 None
 1.44A 2h21A-3q8yA:
undetectable		 2h21A-3q8yA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		5 / 11 GLU A  76
GLY A  77
LEU A  30
ARG A 143
TYR A 139
 None
 1.42A 2h21B-3q8yA:
undetectable		 2h21B-3q8yA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		5 / 11 GLU A  76
GLY A  77
LEU A  30
ARG A 143
TYR A 139
 None
 1.46A 2h21C-3q8yA:
undetectable		 2h21C-3q8yA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		5 / 11 ARG A  15
GLN A  39
VAL A  40
PRO A  41
ILE A   8
 None
 1.39A 3ganA-3q8yA:
undetectable		 3ganA-3q8yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		3 / 3 SER A 100
GLY A 103
SER A  90
 None
 0.57A 3loqA-3q8yA:
undetectable		 3loqA-3q8yA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 6 HIS A 115
GLU A 126
ASP A 118
SER A 122
 VO4  A 159 (-2.7A)
None
ADP  A 158 (-4.1A)
None
 1.19A 4apjA-3q8yA:
undetectable
4apjP-3q8yA:
undetectable		 4apjA-3q8yA:
15.17
4apjP-3q8yA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 5 SER A 117
ALA A 123
HIS A 115
LEU A   6
 None
None
VO4  A 159 (-2.7A)
None
 1.45A 5dzkb-3q8yA:
undetectable
5dzkp-3q8yA:
undetectable		 5dzkb-3q8yA:
21.17
5dzkp-3q8yA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 5 SER A 117
ALA A 123
HIS A 115
LEU A   6
 None
None
VO4  A 159 (-2.7A)
None
 1.43A 5dzkc-3q8yA:
undetectable
5dzkq-3q8yA:
undetectable		 5dzkc-3q8yA:
21.17
5dzkq-3q8yA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 5 ILE A  65
HIS A  48
HIS A 115
TYR A  49
 None
None
VO4  A 159 (-2.7A)
None
 1.12A 5ocsA-3q8yA:
undetectable		 5ocsA-3q8yA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3q8y NUCLEOSIDE
DIPHOSPHATE KINASE
(Staphylococcus
aureus) 		4 / 5 ILE A  65
HIS A  48
HIS A 115
TYR A  49
 None
None
VO4  A 159 (-2.7A)
None
 1.12A 5ocsC-3q8yA:
undetectable		 5ocsC-3q8yA:
17.16