SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 ILE A  64
ALA A  88
ILE A 368
PRO A 365
LEU A 159
 None
 1.19A 1dlsA-3q98A:
undetectable		 1dlsA-3q98A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 9 LEU A  35
ALA A 174
LEU A 186
LEU A 183
PHE A 218
 None
 1.01A 1nr6A-3q98A:
undetectable		 1nr6A-3q98A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 5 MET A 215
TYR A 268
ILE A 191
ASP A 172
 None
 1.19A 1upfA-3q98A:
undetectable		 1upfA-3q98A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 PHE A  58
ARG A  49
ASN A  83
 None
 0.82A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 PHE A  58
ARG A 394
ASN A  83
 None
 0.90A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LYS A 203
GLU A 344
GLY A 343
ASN A 304
ASP A 334
 None
 1.06A 2br4B-3q98A:
undetectable		 2br4B-3q98A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 7 ALA A 333
TYR A 327
ILE A 335
HIS A 311
 None
 0.96A 2zm7A-3q98A:
undetectable		 2zm7A-3q98A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 7 TYR A  78
ILE A 372
GLY A  63
LEU A 159
 None
 0.89A 3elzA-3q98A:
undetectable		 3elzA-3q98A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A  15
SER A  17
LEU A  19
ILE A  12
LYS A 379
 None
 1.45A 3iltB-3q98A:
undetectable
3iltE-3q98A:
undetectable		 3iltB-3q98A:
22.47
3iltE-3q98A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
 None
 1.11A 3ou6A-3q98A:
2.4		 3ou6A-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
 None
 1.10A 3ou6B-3q98A:
undetectable		 3ou6B-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
 None
 1.13A 3ou7A-3q98A:
undetectable		 3ou7A-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
 None
 1.10A 3ou7B-3q98A:
undetectable		 3ou7B-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
 None
 1.10A 3ou7D-3q98A:
2.4		 3ou7D-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 8 PRO A 154
LEU A  87
LEU A  82
ILE A 119
 None
 0.77A 3u5kD-3q98A:
undetectable		 3u5kD-3q98A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 7 TYR A 126
ILE A 163
PRO A 204
HIS A 165
 None
 1.08A 4g5jA-3q98A:
undetectable		 4g5jA-3q98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 ILE A  64
ALA A  88
ILE A 368
PRO A 365
LEU A 159
 None
 1.11A 4gh8A-3q98A:
undetectable		 4gh8A-3q98A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 GLU A 107
MET A 111
ILE A 112
ALA A 132
LEU A  92
 None
 0.86A 4v01A-3q98A:
undetectable		 4v01A-3q98A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 5 GLY A 213
PRO A  32
THR A  27
THR A 216
 None
 1.21A 5h5fA-3q98A:
undetectable		 5h5fA-3q98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 LEU A 224
GLN A 253
VAL A 237
LEU A 205
GLY A 229
 None
 1.38A 5i8fA-3q98A:
undetectable		 5i8fA-3q98A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 VAL A 236
ARG A 122
PRO A 204
 None
 0.85A 5koxA-3q98A:
undetectable		 5koxA-3q98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 4 LEU A  35
LEU A  39
SER A 169
ALA A 174
 None
 1.06A 5uunA-3q98A:
undetectable		 5uunA-3q98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 LEU A 293
LEU A 285
ARG A 281
 None
 0.61A 6fgcA-3q98A:
3.4		 6fgcA-3q98A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3q98 TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 LEU A 293
LEU A 285
ARG A 281
 None
 0.57A 6fgdA-3q98A:
4.2		 6fgdA-3q98A:
22.45