SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3q9n COA BINDING PROTEIN
CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli;
Escherichia
coli) 		4 / 6 TRP A  88
ARG A  89
GLY C  68
ASP C  65
 None
 1.44A 1kf6M-3q9nA:
2.1
1kf6N-3q9nA:
undetectable		 1kf6M-3q9nA:
13.47
1kf6N-3q9nA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3q9n COA BINDING PROTEIN
(Escherichia
coli) 		4 / 5 ILE A  12
ARG A 136
TRP A 103
PRO A   3
 None
 1.48A 1s8fA-3q9nA:
undetectable
1s8fB-3q9nA:
2.2		 1s8fA-3q9nA:
20.94
1s8fB-3q9nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3q9n COA BINDING PROTEIN
CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		4 / 5 ASP C 139
LEU C 133
GLY C 134
ARG A 115
 None
 1.23A 2j2pA-3q9nC:
undetectable
2j2pB-3q9nC:
undetectable		 2j2pA-3q9nC:
18.89
2j2pB-3q9nC:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3q9n COA BINDING PROTEIN
(Escherichia
coli) 		4 / 4 TYR A  47
LEU A  43
LEU A  42
HIS A 134
 None
 1.46A 2x7hB-3q9nA:
5.9		 2x7hB-3q9nA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3q9n COA BINDING PROTEIN
CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		4 / 5 TYR A  93
ALA C  67
ALA A  87
TYR A 109
 None
 1.30A 3d91A-3q9nA:
undetectable		 3d91A-3q9nA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3q9n COA BINDING PROTEIN
CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		4 / 6 ASN A 127
GLY C  79
PRO A  84
THR A 108
 None
 1.00A 4l1aB-3q9nA:
undetectable		 4l1aB-3q9nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3q9n COA BINDING PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 128
TRP A 103
ILE A  12
 None
 1.05A 4mwxA-3q9nA:
undetectable		 4mwxA-3q9nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 11 ILE C  83
LEU C  72
HIS C  90
LEU C  88
ALA C  92
 None
 1.06A 4p65E-3q9nC:
undetectable
4p65F-3q9nC:
undetectable
4p65J-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65E-3q9nC:
8.97
4p65F-3q9nC:
11.35
4p65J-3q9nC:
11.35
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 11 ILE C 116
LEU C 105
HIS C 123
LEU C 121
ALA C 125
 None
 1.08A 4p65E-3q9nC:
undetectable
4p65F-3q9nC:
undetectable
4p65J-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65E-3q9nC:
8.97
4p65F-3q9nC:
11.35
4p65J-3q9nC:
11.35
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 12 VAL C  18
LEU C   6
LEU C  39
ILE C  50
ALA C  59
 None
 1.00A 4p65B-3q9nC:
undetectable
4p65D-3q9nC:
undetectable
4p65I-3q9nC:
undetectable
4p65J-3q9nC:
undetectable		 4p65B-3q9nC:
11.35
4p65D-3q9nC:
11.35
4p65I-3q9nC:
8.97
4p65J-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 12 VAL C  84
LEU C  72
LEU C 105
ILE C 116
ALA C 125
 None
 1.01A 4p65B-3q9nC:
undetectable
4p65D-3q9nC:
undetectable
4p65I-3q9nC:
undetectable
4p65J-3q9nC:
undetectable		 4p65B-3q9nC:
11.35
4p65D-3q9nC:
11.35
4p65I-3q9nC:
8.97
4p65J-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 12 LEU C  39
VAL C  18
LEU C   6
ILE C  50
ALA C  59
 None
 1.05A 4p65F-3q9nC:
undetectable
4p65H-3q9nC:
undetectable
4p65K-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65F-3q9nC:
11.35
4p65H-3q9nC:
11.35
4p65K-3q9nC:
8.97
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		5 / 12 LEU C 105
VAL C  84
LEU C  72
ILE C 116
ALA C 125
 None
 1.04A 4p65F-3q9nC:
undetectable
4p65H-3q9nC:
undetectable
4p65K-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65F-3q9nC:
11.35
4p65H-3q9nC:
11.35
4p65K-3q9nC:
8.97
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		4 / 8 LEU C 120
LEU C  87
TYR C  77
TRP C 102
 None
 1.18A 5hbsA-3q9nC:
undetectable		 5hbsA-3q9nC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3q9n CONSENSUS ANKYRIN
REPEAT
(Escherichia
coli) 		4 / 7 LEU C  36
LEU C  41
ALA C  43
ALA C  44
 None
 0.73A 6a7jA-3q9nC:
undetectable		 6a7jA-3q9nC:
24.83