SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 8 GLY A 384
SER A 313
THR A 324
ASP A 373
 None
 0.87A 1m4iA-3qa8A:
undetectable		 1m4iA-3qa8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 220
VAL A 229
TRP A 226
 None
 0.96A 1qw6A-3qa8A:
undetectable		 1qw6A-3qa8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 220
VAL A 229
TRP A 226
 None
 1.06A 1qwcA-3qa8A:
undetectable		 1qwcA-3qa8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 5 PHE A 390
LEU A 353
MET A 315
LEU A 448
 None
 1.49A 1skxA-3qa8A:
undetectable		 1skxA-3qa8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 220
VAL A 229
TRP A 226
 None
 0.99A 1vagA-3qa8A:
undetectable		 1vagA-3qa8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 220
VAL A 229
TRP A 226
 None
 1.06A 1zviA-3qa8A:
undetectable		 1zviA-3qa8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		6 / 12 LEU A  21
GLY A  22
VAL A  29
ALA A  42
MET A  96
TYR A  98
 None
 0.85A 2fumC-3qa8A:
20.9		 2fumC-3qa8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		7 / 12 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
MET A  96
LYS A 147
 None
 0.76A 2fumD-3qa8A:
21.4		 2fumD-3qa8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		7 / 12 LEU A  21
GLY A  22
VAL A  29
ALA A  42
MET A  96
LYS A 147
ASN A 150
 None
 1.05A 2fumD-3qa8A:
21.4		 2fumD-3qa8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 7 THR A 261
ALA A 252
TYR A 423
PHE A 255
 None
 1.01A 2hzqA-3qa8A:
undetectable		 2hzqA-3qa8A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		9 / 12 LEU A  21
GLY A  22
GLY A  24
GLY A  27
VAL A  29
ALA A  42
LYS A  44
MET A  96
TYR A  98
 None
 0.73A 3fupA-3qa8A:
20.2		 3fupA-3qa8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		8 / 12 LEU A  21
GLY A  22
VAL A  29
ALA A  42
LYS A  44
VAL A  74
MET A  96
TYR A  98
 None
 0.69A 3fupB-3qa8A:
20.2		 3fupB-3qa8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 6 VAL A  73
ILE A 141
HIS A 143
ILE A 164
 None
 0.69A 3hegA-3qa8A:
17.2		 3hegA-3qa8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		8 / 12 LEU A  21
GLY A  22
VAL A  29
ALA A  42
LYS A  44
VAL A  74
MET A  96
TYR A  98
 None
 0.79A 3lxkA-3qa8A:
20.4		 3lxkA-3qa8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		7 / 12 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
LYS A  44
TYR A  98
 None
 0.67A 3lxnA-3qa8A:
21.0		 3lxnA-3qa8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 SER A 130
SER A 131
HIS A 137
 None
 0.80A 3mzeA-3qa8A:
undetectable		 3mzeA-3qa8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 5 LEU A 178
GLN A  63
GLU A  61
HIS A 143
 None
 1.47A 3n58C-3qa8A:
undetectable		 3n58C-3qa8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 8 VAL A  73
VAL A  74
CYH A  99
ILE A 164
 None
 0.64A 3wzeA-3qa8A:
17.4		 3wzeA-3qa8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		6 / 11 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
TYR A  98
 None
 0.87A 4ckiA-3qa8A:
19.5		 4ckiA-3qa8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		5 / 12 ASN A 316
SER A 319
LEU A 403
VAL A 605
LEU A 440
 None
 1.34A 4k36A-3qa8A:
undetectable		 4k36A-3qa8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		5 / 11 ASN A 316
SER A 319
LEU A 403
VAL A 605
LEU A 440
 None
 1.47A 4k37B-3qa8A:
undetectable		 4k37B-3qa8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 7 VAL A  29
ALA A  42
MET A  96
ASP A 103
 None
 0.68A 4l9iA-3qa8A:
5.9		 4l9iA-3qa8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 7 GLU A 477
GLU A 475
GLU A 640
ARG A 637
 None
 1.06A 4mi4B-3qa8A:
undetectable
4mi4C-3qa8A:
undetectable		 4mi4B-3qa8A:
15.41
4mi4C-3qa8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 477
GLU A 475
GLU A 640
ARG A 637
 None
 1.06A 4mj8B-3qa8A:
undetectable
4mj8C-3qa8A:
undetectable		 4mj8B-3qa8A:
14.42
4mj8C-3qa8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 8 ILE A 151
ILE A 164
ASN A  72
ALA A 132
 None
 0.75A 4ou1A-3qa8A:
undetectable		 4ou1A-3qa8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		5 / 11 LEU A 108
LEU A 117
LEU A 146
ILE A 151
LEU A 133
 None
 1.03A 4zowA-3qa8A:
undetectable		 4zowA-3qa8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 220
VAL A 229
TRP A 226
 None
 1.12A 5fvoA-3qa8A:
undetectable		 5fvoA-3qa8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		3 / 3 ASN A  72
SER A 131
SER A 130
 None
 0.74A 5gsnA-3qa8A:
undetectable		 5gsnA-3qa8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		5 / 12 GLU A 181
GLY A  27
LEU A  93
ALA A  87
ASN A  89
 None
 1.38A 5kbwA-3qa8A:
undetectable		 5kbwA-3qa8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		4 / 5 LEU A  21
VAL A  29
MET A  96
CYH A  99
 None
 0.61A 5te0A-3qa8A:
19.3		 5te0A-3qa8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		7 / 12 ARG A  31
LEU A  21
VAL A  29
ALA A  42
LYS A  44
GLU A  61
CYH A  99
 None
 0.93A 5y7zA-3qa8A:
18.9		 5y7zA-3qa8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		7 / 12 ARG A  31
LEU A  21
VAL A  29
ALA A  42
LYS A  44
GLU A  61
CYH A  99
 None
 0.93A 5y7zA-3qa8A:
18.9		 5y7zA-3qa8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3qa8 MGC80376 PROTEIN
(Xenopus
laevis) 		5 / 12 GLN A 541
ASP A 535
ALA A 532
LEU A 625
ALA A 622
 None
 1.04A 6bq4B-3qa8A:
undetectable		 6bq4B-3qa8A:
8.66