SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		4 / 6 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.08A 1sn5A-3qacA:
undetectable		 1sn5A-3qacA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		4 / 7 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.04A 3ozkB-3qacA:
undetectable		 3ozkB-3qacA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		3 / 3 GLU A  36
TYR A 349
GLU A  77
 None
 0.80A 4ryaA-3qacA:
undetectable		 4ryaA-3qacA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		3 / 3 LYS A 388
ARG A 352
VAL A 351
 None
 1.03A 4x3uA-3qacA:
undetectable
4x3uB-3qacA:
undetectable		 4x3uA-3qacA:
10.78
4x3uB-3qacA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		4 / 6 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.13A 5a6iA-3qacA:
undetectable		 5a6iA-3qacA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		4 / 5 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.21A 5cr1A-3qacA:
undetectable		 5cr1A-3qacA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		5 / 12 HIS A 148
GLY A  84
ARG A 286
ALA A 285
ILE A  76
 None
 1.04A 5ih0A-3qacA:
undetectable		 5ih0A-3qacA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3qac 11S GLOBULIN SEED
STORAGE PROTEIN
(Amaranthus
hypochondriacus) 		5 / 12 ASN A 168
ILE A 162
ILE A  74
HIS A 148
PRO A  88
 None
 1.16A 6hlpA-3qacA:
undetectable		 6hlpA-3qacA:
21.22