SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		3 / 3 ASP A 212
LYS A  68
ARG A  58
 None
 1.19A 1ra8A-3qboA:
undetectable		 1ra8A-3qboA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 12 ASN A 142
SER A 140
ASP A 141
ASP A  95
ASP A 212
 None
 1.39A 1s14B-3qboA:
undetectable		 1s14B-3qboA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 5 TYR A 338
SER A 336
THR A 153
ASN A 151
 None
None
PLP  A 501 (-2.9A)
None
 1.44A 1yvpA-3qboA:
undetectable		 1yvpA-3qboA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 4 ASP A  56
LEU A 250
GLY A 249
ARG A  21
 None
 1.42A 2j2pD-3qboA:
undetectable
2j2pE-3qboA:
undetectable		 2j2pD-3qboA:
20.05
2j2pE-3qboA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 5 PHE A 252
PHE A  46
SER A  35
PHE A  71
 None
 1.38A 2v0mD-3qboA:
undetectable		 2v0mD-3qboA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 12 ALA A 217
LEU A 221
ALA A  82
VAL A 190
GLY A 189
 None
 1.07A 2ve3A-3qboA:
undetectable		 2ve3A-3qboA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 11 CYH A 149
THR A 153
ASP A 173
SER A 176
LYS A 197
 PLP  A 501 (-3.6A)
PLP  A 501 (-2.9A)
PLP  A 501 (-2.8A)
PLP  A 501 ( 3.9A)
PLP  A 501 (-1.3A)
 0.61A 2z9wA-3qboA:
34.4		 2z9wA-3qboA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 11 CYH A 149
THR A 153
ASP A 173
SER A 176
LYS A 197
 PLP  A 501 (-3.6A)
PLP  A 501 (-2.9A)
PLP  A 501 (-2.8A)
PLP  A 501 ( 3.9A)
PLP  A 501 (-1.3A)
 0.61A 2z9wB-3qboA:
34.4		 2z9wB-3qboA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 5 PRO A 116
THR A 122
VAL A 121
GLY A  99
 None
 1.14A 3elzA-3qboA:
undetectable		 3elzA-3qboA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 8 ASP A 160
ILE A 159
VAL A  97
GLY A  99
 None
 0.79A 4acbC-3qboA:
undetectable		 4acbC-3qboA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 8 SER A 336
GLY A 156
MET A 333
GLY A 326
 None
 0.79A 4fo4B-3qboA:
undetectable		 4fo4B-3qboA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 12 GLY A 194
GLY A  75
CYH A  72
ILE A 199
SER A 175
 PLP  A 501 ( 4.6A)
PLP  A 501 (-3.3A)
None
None
PLP  A 501 (-3.8A)
 1.16A 4iv0B-3qboA:
undetectable		 4iv0B-3qboA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 8 ALA A 103
GLU A 152
ILE A 131
ASP A 120
 None
 0.84A 4kttB-3qboA:
undetectable		 4kttB-3qboA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 7 PRO A 163
VAL A 170
ALA A 172
PHE A 174
 None
 1.01A 4lb2A-3qboA:
undetectable		 4lb2A-3qboA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		5 / 12 GLU A 344
ILE A 337
ALA A 335
PHE A 301
VAL A 299
 None
 1.03A 4u8yB-3qboA:
undetectable		 4u8yB-3qboA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 7 GLU A 257
LYS A 256
LEU A 255
LEU A  60
 None
 0.79A 4wg0B-3qboA:
undetectable
4wg0C-3qboA:
undetectable		 4wg0B-3qboA:
3.38
4wg0C-3qboA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 6 ASP A 160
ILE A 291
ARG A 294
TYR A 276
 None
 1.02A 5igyA-3qboA:
undetectable		 5igyA-3qboA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 6 ASP A 160
ILE A 291
ARG A 294
TYR A 276
 None
 1.02A 5iwuA-3qboA:
undetectable		 5iwuA-3qboA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 3qbo PHOSPHOSERINE
AMINOTRANSFERASE
(Yersinia
pestis) 		4 / 4 GLN A 111
THR A 115
HIS A 218
LEU A  85
 None
 1.45A 6f3nB-3qboA:
undetectable		 6f3nB-3qboA:
22.63