SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 12 ASN A 160
MET A 117
LEU A 119
ILE A  61
LEU A  13
 None
 1.12A 1lhuA-3qbtA:
undetectable		 1lhuA-3qbtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 8 ASN A 126
GLN A 130
ASN A 121
ASP A  89
 None
None
GNP  A 200 (-3.5A)
None
 1.13A 1zzuA-3qbtA:
undetectable		 1zzuA-3qbtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A 201 (-3.2A)
GNP  A 200 (-3.2A)
GNP  A 200 (-3.6A)
GNP  A 200 (-3.2A)
GNP  A 200 (-2.8A)
 0.99A 2b25A-3qbtA:
2.6		 2b25A-3qbtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 8 TYR A  77
HIS B 660
GLY A  42
ILE A  43
 None
None
SO4  B   1 ( 4.2A)
None
 0.65A 2zm9A-3qbtA:
undetectable		 2zm9A-3qbtA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 8 PHE B 572
PHE B 574
PHE B 587
ALA B 617
 None
 0.90A 3t3sF-3qbtB:
undetectable		 3t3sF-3qbtB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 12 LEU A  59
LEU A  11
LEU A  13
ARG A  48
ILE A  50
 None
 1.22A 4f4dA-3qbtA:
3.2		 4f4dA-3qbtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3qbt RAS-RELATED PROTEIN
RAB-8A
INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 671
ILE A  38
GLY A  42
LYS B 604
ILE A  41
 None
None
SO4  B   1 ( 4.2A)
None
None
 1.19A 4o1eB-3qbtB:
undetectable		 4o1eB-3qbtB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		3 / 3 ASP A  44
LEU B 661
GLY B 664
 SO4  B   1 ( 4.1A)
None
None
 0.58A 4xmfA-3qbtA:
undetectable		 4xmfA-3qbtA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.15A 5vcyA-3qbtA:
undetectable		 5vcyA-3qbtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3qbt RAS-RELATED PROTEIN
RAB-8A
INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B 549
PHE A 163
ARG A  48
 None
 1.12A 5yw0A-3qbtB:
undetectable		 5yw0A-3qbtB:
17.55