SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 8 SER A 869
LEU A 893
ASP A 905
GLU A 941
 None
 1.19A 1mxgA-3qciA:
undetectable		 1mxgA-3qciA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 7 TYR A 880
VAL A1064
GLY A1065
THR A1105
 None
None
NX3  A2001 ( 4.5A)
NX3  A2001 ( 4.6A)
 0.93A 2a1mA-3qciA:
undetectable		 2a1mA-3qciA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		3 / 3 ASN A 878
ASN A 908
ARG A1099
 None
 0.76A 2rlcA-3qciA:
undetectable		 2rlcA-3qciA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 7 LEU A1089
ASN A1087
LEU A1116
MET A1076
 None
 1.25A 2w8yA-3qciA:
undetectable		 2w8yA-3qciA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 5 VAL A1056
PHE A 994
ARG A1049
ARG A1099
 None
 1.45A 3bjwE-3qciA:
undetectable		 3bjwE-3qciA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 4 ILE A1095
GLN A1098
VAL A 912
PHE A1091
 None
 1.48A 3ieoA-3qciA:
undetectable		 3ieoA-3qciA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 8 TRP A1026
HIS A1022
PHE A1041
PRO A1032
 None
None
NX3  A2001 (-4.1A)
NX3  A2001 (-4.0A)
 1.40A 3v35A-3qciA:
undetectable		 3v35A-3qciA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		5 / 12 VAL A1072
LEU A1121
LEU A1039
ALA A1119
ALA A1035
 None
 1.14A 4x1kA-3qciA:
undetectable
4x1kB-3qciA:
undetectable		 4x1kA-3qciA:
20.61
4x1kB-3qciA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 6 PRO A1032
PRO A1037
LEU A1039
PHE A1041
 NX3  A2001 (-4.0A)
None
None
NX3  A2001 (-4.1A)
 1.22A 5tl8A-3qciA:
undetectable		 5tl8A-3qciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens) 		4 / 7 THR A 859
LEU A1089
VAL A1072
GLN A1079
 None
 1.13A 5tudA-3qciA:
undetectable		 5tudA-3qciA:
20.91