SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 8 LEU A 900
LEU A 785
LEU A 776
THR A 765
 None
 0.91A 1dvtA-3qcwA:
undetectable
1dvtB-3qcwA:
undetectable		 1dvtA-3qcwA:
7.20
1dvtB-3qcwA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 LEU A 811
LEU A 762
LEU A 830
LEU A1069
 None
 0.84A 1errA-3qcwA:
undetectable		 1errA-3qcwA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		6 / 12 ILE A 949
GLN A 939
PHE A 940
LEU A1060
ALA A1061
HIS A 970
 None
 1.20A 1fbyA-3qcwA:
undetectable		 1fbyA-3qcwA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		6 / 12 ILE A 949
GLN A 939
PHE A 940
LEU A1060
ALA A1061
HIS A 970
 None
 1.20A 1fbyB-3qcwA:
undetectable		 1fbyB-3qcwA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 ASN A 440
ILE A 656
SER A 510
THR A 429
 None
 1.05A 1h7xA-3qcwA:
undetectable		 1h7xA-3qcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 ASN A 440
ILE A 656
SER A 510
THR A 429
 None
 1.05A 1h7xB-3qcwA:
undetectable		 1h7xB-3qcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 ASN A 440
ILE A 656
SER A 510
THR A 429
 None
 1.05A 1h7xC-3qcwA:
undetectable		 1h7xC-3qcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 ASN A 440
ILE A 656
SER A 510
THR A 429
 None
 1.04A 1h7xD-3qcwA:
undetectable		 1h7xD-3qcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 8 THR A 744
VAL A 787
VAL A 749
VAL A 821
 None
 0.88A 1t86A-3qcwA:
undetectable		 1t86A-3qcwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		3 / 3 TRP A 503
LEU A 500
LYS A 661
 None
 1.43A 1yajK-3qcwA:
undetectable		 1yajK-3qcwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 7 PHE A 881
THR A 765
LEU A 849
VAL A 821
 None
 1.02A 1yrdA-3qcwA:
undetectable		 1yrdA-3qcwA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 11 LEU A 342
ILE A 344
LEU A 346
TYR A 330
GLY A 349
 None
 1.19A 2bxmA-3qcwA:
undetectable		 2bxmA-3qcwA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		3 / 3 THR A1042
PRO A1047
TYR A 951
 None
 0.72A 2dxrA-3qcwA:
undetectable		 2dxrA-3qcwA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		3 / 3 ASN A 980
ILE A1000
MET A 934
 None
 0.84A 2h42C-3qcwA:
undetectable		 2h42C-3qcwA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 7 LEU A 320
LEU A 322
ILE A 344
ARG A 374
 None
 1.24A 2hc4A-3qcwA:
undetectable		 2hc4A-3qcwA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 8 ILE A 651
ILE A 524
PHE A 513
THR A 517
 None
 0.68A 2w9sE-3qcwA:
undetectable		 2w9sE-3qcwA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 ILE A 524
LEU A 620
ILE A 511
SER A 512
LEU A 559
 None
 1.06A 3cd2A-3qcwA:
undetectable		 3cd2A-3qcwA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 PHE A 515
TYR A 583
ILE A 596
PHE A 587
ILE A 550
 None
 1.30A 3ndiA-3qcwA:
undetectable		 3ndiA-3qcwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 9 ASP A 974
ASN A 957
GLY A 956
ASP A 958
ASP A 955
 None
 1.42A 3sfuA-3qcwA:
undetectable		 3sfuA-3qcwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 8 ARG A 757
GLU A 777
LYS A 784
ARG A 775
 None
 1.09A 4bqfB-3qcwA:
undetectable		 4bqfB-3qcwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 10 LEU A 889
ILE A 887
GLY A 893
SER A 878
THR A 724
 None
 0.89A 4fakA-3qcwA:
undetectable		 4fakA-3qcwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 9 VAL A1314
LEU A1304
ILE A1325
PHE A1300
GLY A1140
 None
 0.94A 4kukA-3qcwA:
undetectable		 4kukA-3qcwA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 7 ARG A1332
ILE A1142
PHE A1135
LEU A1315
 None
 1.03A 4mmcA-3qcwA:
undetectable		 4mmcA-3qcwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 7 ASN A 521
VAL A 648
GLU A 519
ARG A 704
 None
 1.22A 4mv7A-3qcwA:
undetectable		 4mv7A-3qcwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 11 ILE A 949
GLN A 939
LEU A1060
ALA A1061
HIS A 970
 None
 1.11A 4nqaA-3qcwA:
undetectable		 4nqaA-3qcwA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 ILE A 949
GLN A 939
LEU A1060
ALA A1061
HIS A 970
 None
 1.11A 4nqaH-3qcwA:
undetectable		 4nqaH-3qcwA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 LEU A 774
MET A 842
LEU A 789
MET A 742
 None
 1.19A 4okbA-3qcwA:
undetectable		 4okbA-3qcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 GLY A1162
ILE A1291
VAL A1196
VAL A1314
ILE A1289
 None
 0.97A 4q5mA-3qcwA:
undetectable		 4q5mA-3qcwA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 11 ILE A1214
ASP A1236
SER A1305
ILE A1161
LEU A1187
 None
 1.16A 4qi9C-3qcwA:
undetectable		 4qi9C-3qcwA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 ALA A 911
ILE A 858
SER A 755
ILE A 909
 None
 0.72A 4r21A-3qcwA:
undetectable		 4r21A-3qcwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 THR A 408
SER A 303
LEU A 415
ASP A 306
 None
 1.05A 4wozA-3qcwA:
undetectable
4wozB-3qcwA:
undetectable		 4wozA-3qcwA:
14.22
4wozB-3qcwA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 10 LEU A 774
LEU A 776
SER A 878
LEU A 751
LEU A 830
 None
 1.19A 4yiaA-3qcwA:
undetectable		 4yiaA-3qcwA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 9 ILE A1142
PHE A1135
GLY A1140
ILE A1327
ALA A1326
 None
 1.36A 4yp2B-3qcwA:
undetectable		 4yp2B-3qcwA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 9 ILE A1142
PHE A1135
GLY A1140
ILE A1327
ALA A1326
 None
 1.37A 5cf9B-3qcwA:
undetectable		 5cf9B-3qcwA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 TYR A 605
ASN A 439
ASP A 657
LEU A 620
PHE A 548
 None
 1.37A 5dv4A-3qcwA:
undetectable		 5dv4A-3qcwA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 5 GLY A 674
PRO A 626
THR A 672
THR A 493
 None
 1.25A 5h5fA-3qcwA:
undetectable		 5h5fA-3qcwA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 7 ILE A1214
HIS A1188
LEU A1172
ALA A1170
 None
 0.89A 5hrqE-3qcwA:
undetectable
5hrqF-3qcwA:
undetectable
5hrqJ-3qcwA:
undetectable		 5hrqE-3qcwA:
1.70
5hrqF-3qcwA:
2.49
5hrqJ-3qcwA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 GLU A 519
GLY A 701
ARG A 699
ARG A 717
 None
 1.15A 5jcnB-3qcwA:
undetectable		 5jcnB-3qcwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 LEU A 346
LEU A 415
ILE A 301
PHE A 421
VAL A 394
 None
 1.44A 5uanB-3qcwA:
undetectable		 5uanB-3qcwA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		3 / 3 ARG A1068
PHE A 938
LEU A1033
 None
 0.66A 5x1bC-3qcwA:
undetectable		 5x1bC-3qcwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		6 / 12 ILE A 949
GLN A 939
PHE A 940
LEU A1060
ALA A1061
HIS A 970
 None
 1.41A 6a5zL-3qcwA:
undetectable		 6a5zL-3qcwA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		5 / 12 PHE A 491
VAL A 585
THR A 517
GLY A 649
MET A 552
 None
 1.37A 6brdA-3qcwA:
undetectable		 6brdA-3qcwA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 PHE A1283
ARG A1226
ASN A1310
ASP A1157
 None
 1.28A 6dhbA-3qcwA:
undetectable		 6dhbA-3qcwA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3qcw NEUREXIN-1-ALPHA
(Bos
taurus) 		4 / 6 GLY A 790
ASN A 788
ASP A 772
SER A 770
 None
 1.14A 6dwdA-3qcwA:
undetectable
6dwdC-3qcwA:
undetectable		 6dwdA-3qcwA:
18.19
6dwdC-3qcwA:
18.19