SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
3 / 3 PHE B 589
TRP B 654
GLU B 656
None
1.12A 1mogA-3qd2B:
undetectable
1mogA-3qd2B:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 7 MET B 945
ASP B 946
ASP B 947
HIS B 914
None
1.39A 1t03A-3qd2B:
undetectable
1t03A-3qd2B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 ALA B 616
GLU B 635
LEU B 639
CYH B 889
HIS B 933
GLY B 952
None
0.77A 1uwhA-3qd2B:
21.8
1uwhA-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 ALA B 616
GLU B 635
LEU B 639
HIS B 933
GLY B 952
PHE B 942
None
1.42A 1uwhA-3qd2B:
21.8
1uwhA-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 ALA B 616
LYS B 618
GLU B 635
LEU B 639
CYH B 889
HIS B 933
GLY B 952
None
0.76A 1uwhB-3qd2B:
21.7
1uwhB-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
GLU B 635
CYH B 889
HIS B 933
GLY B 952
None
0.76A 1uwjA-3qd2B:
21.5
1uwjA-3qd2B:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
GLU B 635
CYH B 889
HIS B 933
GLY B 952
None
0.75A 1uwjB-3qd2B:
21.6
1uwjB-3qd2B:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 922
LEU B1008
ILE B1069
ILE B1070
LEU B 936
None
1.20A 1xdkB-3qd2B:
undetectable
1xdkB-3qd2B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 7 LEU B1015
LEU B1012
ILE B1005
ARG B1063
None
1.14A 2hc4A-3qd2B:
undetectable
2hc4A-3qd2B:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
3 / 3 ASP B 906
ARG B 907
ARG B 901
None
1.10A 2j9dA-3qd2B:
2.7
2j9dC-3qd2B:
undetectable
2j9dA-3qd2B:
19.02
2j9dC-3qd2B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
3 / 3 LEU B 894
MET B 898
MET B 595
None
0.95A 2vavF-3qd2B:
2.7
2vavF-3qd2B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 8 TYR B 883
GLN B 885
ILE B 617
SER B 583
None
1.01A 2xytE-3qd2B:
undetectable
2xytE-3qd2B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 8 TYR B 883
GLN B 885
ILE B 617
SER B 583
None
1.05A 2xytH-3qd2B:
undetectable
2xytH-3qd2B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 7 TYR B 883
GLN B 885
ILE B 617
SER B 583
None
1.04A 2xytI-3qd2B:
undetectable
2xytI-3qd2B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
GLU B 635
LEU B 639
LEU B 888
None
0.52A 3hecA-3qd2B:
21.1
3hecA-3qd2B:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 6 VAL B 603
LYS B 618
VAL B 648
ILE B 884
None
0.70A 3mssD-3qd2B:
21.3
3mssD-3qd2B:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 955
None
0.90A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
PHE B 954
None
0.77A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
LEU B 639
PHE B 942
PHE B 954
None
0.89A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
ASP B 896
ASP B 935
LYS B 937
ASN B 940
ASP B 953
None
0.70A 4i41A-3qd2B:
24.9
4i41A-3qd2B:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 8 MET B 886
LEU B 882
ALA B 653
LEU B 655
None
0.82A 4ik6B-3qd2B:
undetectable
4ik6B-3qd2B:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 7 LEU B1012
ILE B1028
ILE B1029
VAL B1032
None
0.78A 4ojbA-3qd2B:
undetectable
4ojbA-3qd2B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 11 ALA B 616
LYS B 618
GLU B 635
ILE B 884
MET B 886
ASP B 953
None
0.75A 4qmsA-3qd2B:
25.8
4qmsA-3qd2B:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 9 ILE B 617
PRO B 591
GLN B 885
TYR B 615
ASP B 611
None
1.46A 4qopD-3qd2B:
0.0
4qopD-3qd2B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
GLU B 635
CYH B 889
GLY B 952
None
0.78A 4r7iA-3qd2B:
20.5
4r7iA-3qd2B:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
None
0.52A 4rzvA-3qd2B:
22.3
4rzvA-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
PHE B 942
GLY B 952
PHE B 954
None
0.91A 4rzvA-3qd2B:
22.3
4rzvA-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
GLY B 955
None
1.26A 4rzvB-3qd2B:
22.3
4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
None
1.02A 4rzvB-3qd2B:
22.3
4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
None
0.71A 4xv2A-3qd2B:
22.7
4xv2A-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
None
0.75A 4xv2A-3qd2B:
22.7
4xv2A-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
None
0.70A 4xv2B-3qd2B:
22.7
4xv2B-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 ALA B 616
LYS B 618
LEU B 639
PHE B 942
GLY B 952
ASP B 953
PHE B 954
None
0.83A 4xv2B-3qd2B:
22.7
4xv2B-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
None
0.81A 5cswA-3qd2B:
22.4
5cswA-3qd2B:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
LEU B 639
PHE B 942
PHE B 954
None
0.98A 5cswA-3qd2B:
22.4
5cswA-3qd2B:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
7 / 12 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
None
0.84A 5cswB-3qd2B:
22.4
5cswB-3qd2B:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
ILE B 884
LEU B 888
GLY B 952
ASP B 953
None
0.69A 5h2uB-3qd2B:
16.1
5h2uB-3qd2B:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
ILE B 884
LEU B 888
GLY B 952
ASP B 953
None
0.66A 5h2uD-3qd2B:
21.8
5h2uD-3qd2B:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 VAL B 603
ALA B 616
LYS B 618
ILE B 884
ASP B 896
GLY B 955
None
1.15A 5hesB-3qd2B:
21.5
5hesB-3qd2B:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 ALA B 616
LYS B 618
GLU B 635
LEU B 639
CYH B 889
GLY B 952
None
0.75A 5hi2A-3qd2B:
22.2
5hi2A-3qd2B:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 ALA B 616
LYS B 618
LEU B 639
CYH B 889
HIS B 933
GLY B 952
None
0.82A 5hi2A-3qd2B:
22.2
5hi2A-3qd2B:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
None
0.61A 5hieA-3qd2B:
21.5
5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
None
0.52A 5hieA-3qd2B:
21.5
5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
None
0.58A 5hieA-3qd2B:
21.5
5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 VAL B 603
ALA B 616
ILE B 884
PHE B 942
GLY B 952
None
0.68A 5hieA-3qd2B:
21.5
5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
None
0.63A 5hieB-3qd2B:
21.6
5hieB-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
None
0.54A 5hieB-3qd2B:
21.6
5hieB-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
None
0.59A 5hieB-3qd2B:
21.6
5hieB-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 VAL B 603
ALA B 616
ILE B 884
PHE B 942
GLY B 952
None
0.69A 5hieB-3qd2B:
21.6
5hieB-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 GLY B 596
ALA B 616
LYS B 618
PHE B 942
GLY B 952
ASP B 953
None
0.87A 5hieC-3qd2B:
22.0
5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 GLY B 596
VAL B 603
ALA B 616
PHE B 942
GLY B 952
ASP B 953
None
0.83A 5hieC-3qd2B:
22.0
5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
ASP B 953
None
0.55A 5hieC-3qd2B:
22.0
5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
6 / 12 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
ASP B 953
None
0.63A 5hieC-3qd2B:
22.0
5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
None
0.60A 5hieD-3qd2B:
21.9
5hieD-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
None
0.51A 5hieD-3qd2B:
21.9
5hieD-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
None
0.58A 5hieD-3qd2B:
21.9
5hieD-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 VAL B 603
ALA B 616
ILE B 884
PHE B 942
GLY B 952
None
0.68A 5hieD-3qd2B:
21.9
5hieD-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 10 ASP B1004
ILE B1069
PHE B 916
SER B1007
GLY B1009
None
1.18A 5i6xA-3qd2B:
undetectable
5i6xA-3qd2B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 8 ALA B 616
GLU B 635
CYH B 889
ASP B 953
None
0.46A 5owrA-3qd2B:
20.4
5owrA-3qd2B:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
4 / 5 VAL B 603
LEU B 888
CYH B 889
ASP B 953
None
0.72A 5vcvA-3qd2B:
19.9
5vcvA-3qd2B:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 638
VAL B 951
ALA B 922
LEU B1008
LEU B 936
None
1.06A 5x23A-3qd2B:
undetectable
5x23A-3qd2B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 ALA B 638
VAL B 951
ALA B 922
LEU B1008
LEU B 936
None
1.08A 5xxiA-3qd2B:
undetectable
5xxiA-3qd2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus
musculus)
5 / 12 LEU B1008
LEU B 936
ILE B 647
ALA B 922
HIS B 927
None
1.30A 6n91B-3qd2B:
undetectable
6n91B-3qd2B:
12.84