SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qe3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 10 ALA A  91
GLU A 149
LEU A 309
LEU A 141
PRO A 142
 None
 1.34A 1cmcA-3qe3A:
undetectable
1cmcB-3qe3A:
undetectable		 1cmcA-3qe3A:
20.38
1cmcB-3qe3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 7 TRP A 302
TYR A 139
ASN A 300
TYR A 109
 None
 1.44A 1kiaC-3qe3A:
7.4		 1kiaC-3qe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 7 TRP A 302
TYR A 139
ASN A 300
TYR A 109
 None
 1.45A 1kiaD-3qe3A:
7.4		 1kiaD-3qe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 11 GLU A 149
LEU A 309
LEU A 141
PRO A 142
ALA A  91
 None
 1.28A 1mjqA-3qe3A:
undetectable
1mjqB-3qe3A:
undetectable		 1mjqA-3qe3A:
17.69
1mjqB-3qe3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 10 GLU A 149
LEU A 309
LEU A 141
PRO A 142
ALA A  91
 None
 1.31A 1mjqC-3qe3A:
undetectable
1mjqD-3qe3A:
undetectable		 1mjqC-3qe3A:
17.69
1mjqD-3qe3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 11 GLU A 149
LEU A 309
LEU A 141
PRO A 142
ALA A  91
 None
 1.32A 1mjqI-3qe3A:
undetectable
1mjqJ-3qe3A:
undetectable		 1mjqI-3qe3A:
17.69
1mjqJ-3qe3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 7 TRP A 302
TYR A 139
ASN A 300
TYR A 109
 None
 1.44A 1nbhB-3qe3A:
7.0		 1nbhB-3qe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 7 TRP A 302
TYR A 139
ASN A 300
TYR A 109
 None
 1.43A 1nbhD-3qe3A:
7.1		 1nbhD-3qe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 8 PHE A 333
GLY A 125
VAL A  40
ILE A  42
 None
 0.80A 2a1mB-3qe3A:
undetectable		 2a1mB-3qe3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 6 PHE A 147
SER A  39
GLY A  72
THR A  73
 None
 1.12A 2f7fA-3qe3A:
3.8		 2f7fA-3qe3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 7 LEU A 220
GLN A 256
ALA A 285
ILE A 292
 None
 0.85A 2xkwA-3qe3A:
undetectable		 2xkwA-3qe3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		3 / 3 GLY A 180
ASP A 202
SER A 204
 None
 0.63A 3brfA-3qe3A:
undetectable		 3brfA-3qe3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 12 ALA A 151
SER A  71
ASN A   7
LEU A 127
GLY A  67
 None
 1.23A 3nrrA-3qe3A:
2.5		 3nrrA-3qe3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 12 ALA A 151
SER A  71
ASN A   7
LEU A 127
GLY A  67
 None
 1.24A 3nrrB-3qe3A:
2.5		 3nrrB-3qe3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 8 GLY A 341
PRO A 318
GLU A 213
ARG A 323
 None
 0.95A 3s3mA-3qe3A:
2.1		 3s3mA-3qe3A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ILE A 306
VAL A  90
LEU A  35
CYH A 138
 None
 0.91A 4asdA-3qe3A:
undetectable		 4asdA-3qe3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 12 LEU A 208
ALA A 211
ILE A 182
SER A 204
GLY A 159
 None
 1.03A 4dm8B-3qe3A:
undetectable		 4dm8B-3qe3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 12 GLY A 178
ASP A 202
LEU A 203
SER A 204
VAL A 251
 None
 0.81A 5dpdB-3qe3A:
7.2		 5dpdB-3qe3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ALA A 119
VAL A  65
VAL A  40
HIS A  68
 None
None
None
ZN  A 356 ( 3.2A)
 1.06A 5eckD-3qe3A:
undetectable		 5eckD-3qe3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ALA A 119
VAL A  65
VAL A  40
HIS A  68
 None
None
None
ZN  A 356 ( 3.2A)
 1.02A 5eclA-3qe3A:
undetectable		 5eclA-3qe3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		6 / 12 THR A 245
ILE A 222
ALA A 257
GLY A 258
ALA A 231
ILE A 230
 None
 1.13A 5kb6A-3qe3A:
5.4		 5kb6A-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		6 / 12 THR A 245
VAL A 199
ILE A 222
ALA A 257
GLY A 258
ILE A 230
 None
 1.16A 5kb6A-3qe3A:
5.4		 5kb6A-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		6 / 12 THR A 245
ILE A 222
ALA A 257
GLY A 258
ALA A 231
ILE A 230
 None
 1.14A 5kb6B-3qe3A:
4.1		 5kb6B-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		6 / 12 THR A 245
VAL A 199
ILE A 222
ALA A 257
GLY A 258
ILE A 230
 None
 1.15A 5kb6B-3qe3A:
4.1		 5kb6B-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		5 / 12 VAL A  59
PRO A 121
THR A 120
PHE A 296
GLY A  95
 None
None
GOL  A 357 (-2.9A)
None
None
 1.29A 5xipC-3qe3A:
2.0		 5xipC-3qe3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3qe3 SORBITOL
DEHYDROGENASE
(Ovis
aries) 		4 / 4 HIS A  83
VAL A  74
LEU A  84
ALA A 135
 None
 1.28A 6d8pB-3qe3A:
3.0		 6d8pB-3qe3A:
19.32