SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 10 GLY A 545
PHE A 543
LEU A 582
THR A 563
LEU A 591
 None
 0.95A 1a8uA-3qfsA:
undetectable		 1a8uA-3qfsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 10 GLY A 545
PHE A 543
LEU A 582
THR A 563
LEU A 591
 None
 0.99A 1a8uB-3qfsA:
undetectable		 1a8uB-3qfsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 5 PHE A 646
TYR A 674
LEU A 676
VAL A 608
 None
 1.38A 1dz6A-3qfsA:
undetectable		 1dz6A-3qfsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 7 GLU A 581
LEU A 295
TYR A 576
ILE A 544
 None
 1.06A 1tuvA-3qfsA:
undetectable		 1tuvA-3qfsA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 7 ALA A 324
ILE A 315
ASP A 280
PHE A 279
 None
 0.89A 1upfB-3qfsA:
undetectable		 1upfB-3qfsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 8 LYS A 621
THR A 529
PRO A 530
LEU A 564
 None
 0.86A 1z2bB-3qfsA:
3.0		 1z2bB-3qfsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 565
GLY A 539
CYH A 475
ALA A 541
ALA A 462
 None
None
None
FAD  A 752 ( 3.7A)
None
 1.11A 2br4A-3qfsA:
3.3		 2br4A-3qfsA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A 343
LEU A 374
ILE A 430
LEU A 451
PRO A 452
 None
 1.17A 2qk8A-3qfsA:
undetectable		 2qk8A-3qfsA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 539
GLY A 633
ASP A 677
ASP A 575
LEU A 577
 None
None
FAD  A 752 ( 4.9A)
None
None
 1.24A 2zw9B-3qfsA:
3.0		 2zw9B-3qfsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 6 VAL A 516
VAL A 323
PHE A 279
ARG A 457
 None
None
None
FAD  A 752 (-3.9A)
 1.26A 3bjwF-3qfsA:
undetectable		 3bjwF-3qfsA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 537
GLY A 568
VAL A 534
ALA A 541
SER A 599
 NAP  A 753 (-3.5A)
NAP  A 753 ( 4.7A)
None
FAD  A 752 ( 3.7A)
NAP  A 753 (-2.7A)
 1.23A 3mteA-3qfsA:
2.3		 3mteA-3qfsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 6 ASN A 489
HIS A 429
PRO A 383
ASP A 436
 None
 1.30A 3oi8A-3qfsA:
undetectable		 3oi8A-3qfsA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 10 LEU A 565
ALA A 541
PHE A 543
GLY A 545
ILE A 547
 None
FAD  A 752 ( 3.7A)
None
None
None
 1.01A 3qpsA-3qfsA:
undetectable		 3qpsA-3qfsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 7 ARG A 554
GLY A 561
GLU A 559
GLN A 593
 None
 1.04A 4g0vA-3qfsA:
undetectable		 4g0vA-3qfsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 5 PRO A 452
ASP A 379
ILE A 430
VAL A 334
 None
 1.32A 4hytA-3qfsA:
2.1		 4hytA-3qfsA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 5 HIS A 446
ARG A 246
GLU A 391
LEU A 450
 None
 1.50A 4ig5A-3qfsA:
undetectable		 4ig5A-3qfsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 5 HIS A 446
ARG A 246
GLU A 391
LEU A 450
 None
 1.48A 4ig5B-3qfsA:
undetectable		 4ig5B-3qfsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A 532
ILE A 665
LEU A 668
ARG A 673
ILE A 629
 None
 1.10A 4pthA-3qfsA:
2.8		 4pthA-3qfsA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 VAL A 347
ASP A 346
LEU A 351
GLY A 338
LEU A 341
 None
 1.07A 5m5cB-3qfsA:
undetectable		 5m5cB-3qfsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 10 VAL A 347
ASP A 346
LEU A 351
GLY A 338
LEU A 341
 None
 1.06A 5m5cE-3qfsA:
4.3		 5m5cE-3qfsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 8 LEU A 612
ALA A 627
VAL A 608
TYR A 674
 None
 0.97A 5nu7A-3qfsA:
undetectable		 5nu7A-3qfsA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 PRO A 363
ILE A 444
ILE A 380
LEU A 341
LEU A 434
 None
 1.20A 5tiwA-3qfsA:
undetectable		 5tiwA-3qfsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		3 / 3 MET A 304
GLU A 480
ARG A 498
 None
 1.04A 5tjyA-3qfsA:
undetectable		 5tjyA-3qfsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		3 / 3 MET A 304
GLU A 480
ARG A 498
 None
 1.06A 5tjzA-3qfsA:
3.1		 5tjzA-3qfsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		3 / 3 ARG A 453
PRO A 365
TYR A 326
 None
 0.77A 5tzoB-3qfsA:
undetectable		 5tzoB-3qfsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		6 / 9 SER A 460
THR A 538
GLY A 539
ALA A 541
CYH A 632
GLY A 633
 FAD  A 752 (-3.5A)
NAP  A 753 (-3.0A)
None
FAD  A 752 ( 3.7A)
None
None
 0.42A 5vw4A-3qfsA:
30.0		 5vw4A-3qfsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 8 SER A 460
THR A 538
GLY A 539
CYH A 632
GLY A 633
 FAD  A 752 (-3.5A)
NAP  A 753 (-3.0A)
None
None
None
 0.42A 5vw5A-3qfsA:
29.7		 5vw5A-3qfsA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		6 / 8 SER A 460
THR A 538
GLY A 539
ALA A 541
CYH A 632
GLY A 633
 FAD  A 752 (-3.5A)
NAP  A 753 (-3.0A)
None
FAD  A 752 ( 3.7A)
None
None
 0.43A 5vw9A-3qfsA:
30.0		 5vw9A-3qfsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		4 / 6 PRO A 536
GLY A 568
LEU A 611
VAL A 534
 NAP  A 753 ( 4.6A)
NAP  A 753 ( 4.7A)
None
None
 0.94A 5x80A-3qfsA:
undetectable
5x80B-3qfsA:
undetectable		 5x80A-3qfsA:
19.56
5x80B-3qfsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens) 		5 / 12 VAL A 347
ASP A 346
LEU A 351
GLY A 338
LEU A 341
 None
 1.17A 6b0lB-3qfsA:
4.5		 6b0lB-3qfsA:
10.99