SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
ASN A 205
LEU A 207
ASP A 218
PHE A 370
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
NM7  A 416 (-3.3A)
 0.77A 1fmoE-3qfvA:
35.8		 1fmoE-3qfvA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 316
GLU A 174
LEU A 275
ILE A 321
LEU A 267
 None
 1.30A 1g50A-3qfvA:
undetectable		 1g50A-3qfvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 208
GLY A 212
HIS A 213
ILE A 214
 None
 0.90A 1xf1A-3qfvA:
undetectable		 1xf1A-3qfvA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 206
ILE A 214
LEU A 208
LEU A 165
LEU A 164
 None
 1.12A 2a15A-3qfvA:
undetectable		 2a15A-3qfvA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		3 / 3 LYS A 105
ASP A 204
ASP A 241
 EDO  A 417 (-3.5A)
None
None
 1.10A 2br4A-3qfvA:
undetectable		 2br4A-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		9 / 12 ILE A  82
VAL A  90
LYS A 105
ASP A 160
THR A 163
ASN A 205
LEU A 207
ALA A 217
ASP A 218
 None
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
None
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.78A 2eufB-3qfvA:
24.5		 2eufB-3qfvA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
ASP A 200
LYS A 202
ASN A 205
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
None
EDO  A 417 (-3.7A)
 0.79A 2fumA-3qfvA:
8.3		 2fumA-3qfvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
MET A 153
LYS A 202
ASN A 205
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.6A)
None
None
 0.64A 2fumD-3qfvA:
22.9		 2fumD-3qfvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
GLY A 159
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.81A 2hyyA-3qfvA:
18.6		 2hyyA-3qfvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
GLY A 159
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.80A 2hyyB-3qfvA:
18.6		 2hyyB-3qfvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 128
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.76A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 151
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.78A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 LYS A  80
ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
 None
None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.80A 2y6oA-3qfvA:
18.8		 2y6oA-3qfvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 8 ILE A 188
HIS A 192
ARG A 327
GLY A 329
 None
 0.90A 3b9lA-3qfvA:
undetectable		 3b9lA-3qfvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 5 ILE A 188
HIS A 192
ARG A 327
GLY A 329
 None
 1.03A 3b9mA-3qfvA:
undetectable		 3b9mA-3qfvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		9 / 12 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.79A 3eygA-3qfvA:
22.6		 3eygA-3qfvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		9 / 12 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASN A 205
LEU A 207
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-3.6A)
None
NM7  A 416 ( 4.2A)
 0.78A 3eygA-3qfvA:
22.6		 3eygA-3qfvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
TYR A 155
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
 0.71A 3fupA-3qfvA:
22.4		 3fupA-3qfvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.72A 3fupA-3qfvA:
22.4		 3fupA-3qfvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
LYS A 105
MET A 153
TYR A 155
LEU A 207
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.74A 3fupA-3qfvA:
22.4		 3fupA-3qfvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
LYS A 105
TYR A 155
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.70A 3fupA-3qfvA:
22.4		 3fupA-3qfvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 11 VAL A  90
ALA A 103
TYR A 155
GLY A 159
ASP A 160
LEU A 207
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-4.4A)
None
None
NM7  A 416 ( 4.2A)
 0.67A 3g0fA-3qfvA:
15.2		 3g0fA-3qfvA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 PRO A 173
PRO A 356
TRP A 347
ILE A 350
ILE A 214
 None
 1.26A 3ganA-3qfvA:
undetectable		 3ganA-3qfvA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
GLY A 159
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.78A 3k5vA-3qfvA:
14.7		 3k5vA-3qfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
GLY A 159
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.76A 3k5vB-3qfvA:
18.4		 3k5vB-3qfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 7 PHE A  87
GLY A  85
CYH A 120
PHE A 121
 None
 1.07A 3ko0D-3qfvA:
undetectable
3ko0E-3qfvA:
undetectable		 3ko0D-3qfvA:
13.29
3ko0E-3qfvA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
TYR A 155
ALA A 217
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.5A)
 0.78A 3lxkA-3qfvA:
22.5		 3lxkA-3qfvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
LYS A 105
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.63A 3lxnA-3qfvA:
22.5		 3lxnA-3qfvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
TYR A 155
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.54A 3lxnA-3qfvA:
22.5		 3lxnA-3qfvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 132
PHE A 219
LEU A 194
ILE A 191
SER A 190
 None
 1.25A 3o94A-3qfvA:
undetectable		 3o94A-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 132
PHE A 219
LEU A 194
ILE A 191
SER A 190
 None
 1.25A 3o94B-3qfvA:
undetectable		 3o94B-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 132
PHE A 219
LEU A 194
ILE A 191
SER A 190
 None
 1.24A 3o94C-3qfvA:
undetectable		 3o94C-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 132
PHE A 219
LEU A 194
ILE A 191
SER A 190
 None
 1.24A 3o94D-3qfvA:
undetectable		 3o94D-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.76A 3oezB-3qfvA:
19.2		 3oezB-3qfvA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
 0.81A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
ASP A 218
 None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
EDO  A 417 (-3.7A)
 0.80A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.84A 4bkjA-3qfvA:
19.0		 4bkjA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ALA A 103
LYS A 105
GLU A 124
LEU A 128
HIS A 198
LEU A 207
ALA A 217
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.68A 4c8bA-3qfvA:
16.0		 4c8bA-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ALA A 103
LYS A 105
GLU A 124
LEU A 128
ILE A 136
LEU A 207
ALA A 217
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.73A 4c8bB-3qfvA:
16.6		 4c8bB-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ALA A 103
LYS A 105
LEU A 128
ILE A 136
HIS A 198
LEU A 207
ALA A 217
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.66A 4c8bB-3qfvA:
16.6		 4c8bB-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.56A 4csvA-3qfvA:
19.3		 4csvA-3qfvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 151
MET A 153
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
NM7  A 416 (-3.6A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.87A 4i22A-3qfvA:
18.9		 4i22A-3qfvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 VAL A  90
ALA A 103
ASP A 160
ASP A 200
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.61A 4i41A-3qfvA:
25.9		 4i41A-3qfvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 103
LYS A 105
ASP A 160
LEU A 207
ASP A 218
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.66A 4iaaA-3qfvA:
25.8		 4iaaA-3qfvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 VAL A  90
ALA A 103
LYS A 105
ASP A 160
LEU A 207
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
NM7  A 416 ( 4.2A)
 0.67A 4iaaA-3qfvA:
25.8		 4iaaA-3qfvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
LEU A 139
LEU A 151
GLY A 159
LEU A 207
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
None
NM7  A 416 ( 4.2A)
 0.66A 4ifgA-3qfvA:
23.3		 4ifgA-3qfvA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 139
LEU A 151
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
None
 0.52A 4ifgA-3qfvA:
23.3		 4ifgA-3qfvA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 8 HIS A 198
ASP A 263
SER A 233
ASP A 200
 None
 1.17A 4kttC-3qfvA:
undetectable		 4kttC-3qfvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 7 VAL A  90
ALA A 103
LEU A 107
MET A 153
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.6A)
NM7  A 416 (-3.6A)
 0.42A 4l9iA-3qfvA:
24.6		 4l9iA-3qfvA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 7 VAL A  90
ALA A 103
MET A 153
ASP A 160
LEU A 207
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.6A)
None
NM7  A 416 ( 4.2A)
 0.76A 4l9iA-3qfvA:
24.6		 4l9iA-3qfvA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 7 HIS A 198
ASP A 263
SER A 233
ASP A 200
 None
 1.21A 4ndnC-3qfvA:
undetectable		 4ndnC-3qfvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 6 VAL A  90
ALA A 103
LYS A 105
LEU A 207
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 ( 4.2A)
 0.70A 4o0uA-3qfvA:
9.5		 4o0uA-3qfvA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 8 ILE A  82
VAL A  90
ALA A 103
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.51A 4ogrA-3qfvA:
25.4		 4ogrA-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 8 ILE A  82
VAL A  90
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.59A 4ogrA-3qfvA:
25.4		 4ogrA-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 7 ALA A 103
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.59A 4ogrE-3qfvA:
24.6		 4ogrE-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 7 GLY A  83
ALA A 103
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.64A 4ogrE-3qfvA:
24.6		 4ogrE-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 9 ILE A  82
GLY A  85
VAL A  90
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
None
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.91A 4ogrI-3qfvA:
25.6		 4ogrI-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 9 ILE A  82
VAL A  90
ALA A 103
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.69A 4ogrI-3qfvA:
25.6		 4ogrI-3qfvA:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LEU A 207
ALA A 217
PHE A 370
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
NM7  A 416 (-3.3A)
 0.72A 4otiA-3qfvA:
29.3		 4otiA-3qfvA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		9 / 12 ILE A  82
ALA A 103
GLU A 124
THR A 137
MET A 153
TYR A 155
LEU A 207
ALA A 217
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.97A 4qmnA-3qfvA:
26.7		 4qmnA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 ILE A  82
ALA A 103
LYS A 105
GLU A 124
THR A 137
MET A 153
TYR A 155
LEU A 207
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.98A 4qmnA-3qfvA:
26.7		 4qmnA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 11 ILE A  82
ALA A 103
GLU A 124
MET A 153
TYR A 155
LEU A 207
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 1.04A 4qmsA-3qfvA:
21.7		 4qmsA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 11 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.99A 4qmsA-3qfvA:
21.7		 4qmsA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
THR A 137
MET A 153
TYR A 155
LEU A 207
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.73A 4qmzA-3qfvA:
21.6		 4qmzA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 6 ARG A 412
GLU A 406
TYR A 141
LEU A 139
 None
 1.35A 4twdF-3qfvA:
undetectable
4twdG-3qfvA:
0.5		 4twdF-3qfvA:
20.82
4twdG-3qfvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
GLY A 159
ASN A 205
LEU A 207
ALA A 217
ASP A 218
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.78A 4twpA-3qfvA:
21.1		 4twpA-3qfvA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 8 ILE A 214
ARG A 178
LEU A 275
ILE A 181
 None
 0.98A 4xtaB-3qfvA:
undetectable		 4xtaB-3qfvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 345
LEU A 172
LEU A 208
ILE A 214
LEU A 164
 None
 1.05A 4zowA-3qfvA:
undetectable		 4zowA-3qfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 7 ILE A  82
GLY A  83
LEU A 139
ASP A 218
PHE A 219
 None
NM7  A 416 (-3.0A)
None
EDO  A 417 (-3.7A)
None
 1.18A 5hieB-3qfvA:
7.4		 5hieB-3qfvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-3.7A)
 0.52A 5hieC-3qfvA:
20.8		 5hieC-3qfvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.76A 5i9yA-3qfvA:
19.1		 5i9yA-3qfvA:
24.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 7 GLY A  83
GLY A  88
VAL A  90
LEU A 107
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
EDO  A 417 (-4.6A)
 0.33A 5izjB-3qfvA:
30.8		 5izjB-3qfvA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 7 GLY A  83
VAL A  90
LYS A 105
LEU A 107
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
 0.45A 5izjA-3qfvA:
26.9		 5izjA-3qfvA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		8 / 12 GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
ALA A 217
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.66A 5l2iA-3qfvA:
6.5		 5l2iA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
ALA A 217
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.80A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ASP A 160
THR A 163
LEU A 207
ALA A 217
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.89A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
 1.10A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
 0.68A 5mafA-3qfvA:
26.7		 5mafA-3qfvA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 10 VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 207
PHE A 370
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 (-3.3A)
 0.48A 5n3hA-3qfvA:
35.8		 5n3hA-3qfvA:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		4 / 8 ALA A 103
GLU A 124
LEU A 207
ASP A 218
 NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.51A 5owrA-3qfvA:
13.4		 5owrA-3qfvA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
GLU A 124
TYR A 155
GLY A 159
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
None
NM7  A 416 ( 4.5A)
 0.76A 5zv2A-3qfvA:
18.5		 5zv2A-3qfvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
GLY A 159
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.5A)
 0.66A 5zv2B-3qfvA:
3.3		 5zv2B-3qfvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3qfv CDC42BPB PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 321
GLN A 318
GLU A 311
SER A 310
VAL A 309
 None
 1.39A 6bzoC-3qfvA:
undetectable		 6bzoC-3qfvA:
16.86