SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 12 TYR A  62
ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-4.0A)
TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.73A 1dedB-3qgvA:
28.6		 1dedB-3qgvA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 TYR A  62
LEU A  70
SER A  51
HIS A 288
ILE A 192
 TRS  A 505 (-4.0A)
None
None
TRS  A 505 (-4.2A)
None
 1.37A 1fmjA-3qgvA:
0.2		 1fmjA-3qgvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
HIS A 111
ALA A 113
GLU A 222
ASP A 289
 None
None
None
TRS  A 505 (-2.7A)
TRS  A 505 (-3.0A)
 1.25A 1kxhA-3qgvA:
30.2		 1kxhA-3qgvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
HIS A 111
GLY A 161
GLU A 222
ASP A 289
 None
None
None
TRS  A 505 (-2.7A)
TRS  A 505 (-3.0A)
 0.67A 1kxhA-3qgvA:
30.2		 1kxhA-3qgvA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		7 / 9 GLY A   9
LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLY A 338
GLY A 339
 BCD  A 601 (-3.7A)
BCD  A 601 (-2.4A)
BCD  A 601 (-4.0A)
BCD  A 601 (-2.9A)
BCD  A 601 (-3.5A)
BCD  A 601 ( 3.7A)
BCD  A 601 (-3.5A)
 0.17A 1mxdA-3qgvA:
65.1		 1mxdA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 9 LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLY A 339
 BCD  A 601 (-2.4A)
BCD  A 601 (-4.0A)
BCD  A 601 (-2.9A)
BCD  A 601 (-3.5A)
BCD  A 601 (-3.5A)
 0.92A 1mxdA-3qgvA:
65.1		 1mxdA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 6 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
TRP A 171
 None
 0.20A 1mxdA-3qgvA:
65.1		 1mxdA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 6 ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.50A 1mxdA-3qgvA:
65.1		 1mxdA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		12 / 12 TRP A  18
TYR A  62
HIS A 111
PHE A 159
ARG A 196
ASP A 198
TYR A 199
LYS A 201
GLU A 222
TRP A 224
HIS A 288
ASP A 289
 None
TRS  A 505 (-4.0A)
None
TRS  A 505 (-4.4A)
TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.7A)
None
TRS  A 505 (-2.7A)
None
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.43A 1mxdA-3qgvA:
65.1		 1mxdA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		9 / 11 GLY A   9
LYS A 241
PRO A 278
PHE A 279
GLU A 307
GLY A 308
GLN A 309
GLY A 338
GLY A 339
 BCD  A 601 (-3.7A)
BCD  A 601 (-2.4A)
BCD  A 601 (-4.0A)
BCD  A 601 (-4.6A)
BCD  A 601 (-2.9A)
BCD  A 601 (-3.5A)
BCD  A 601 ( 4.6A)
BCD  A 601 ( 3.7A)
BCD  A 601 (-3.5A)
 0.20A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 11 LYS A 241
PRO A 278
GLU A 307
GLY A 308
GLN A 309
GLY A 339
 BCD  A 601 (-2.4A)
BCD  A 601 (-4.0A)
BCD  A 601 (-2.9A)
BCD  A 601 (-3.5A)
BCD  A 601 ( 4.6A)
BCD  A 601 (-3.5A)
 0.99A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		8 / 8 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
GLU A 150
LYS A 169
TRP A 171
 None
 0.23A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		7 / 7 TYR A   3
ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.55A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 ILE A  93
ALA A  96
VAL A 103
LEU A  70
ALA A  50
 None
 1.10A 1n4hA-3qgvA:
undetectable		 1n4hA-3qgvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 SER A 136
GLY A 137
ARG A 112
 None
 0.52A 1t9wA-3qgvA:
undetectable		 1t9wA-3qgvA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A  37
GLU A 318
TYR A 314
 None
 0.90A 2a3aA-3qgvA:
5.5		 2a3aA-3qgvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 ILE A 303
LEU A 329
ILE A 330
HIS A 333
 None
 0.94A 2azxA-3qgvA:
undetectable		 2azxA-3qgvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.19A 2x7hA-3qgvA:
undetectable		 2x7hA-3qgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 SER A 430
PHE A 384
VAL A 404
TYR A 392
 None
 1.16A 2x7hB-3qgvA:
undetectable		 2x7hB-3qgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 SER A   4
LEU A 336
GLY A 338
GLU A 334
 None
None
BCD  A 601 ( 3.7A)
None
 1.04A 3aiaA-3qgvA:
undetectable
3aiaB-3qgvA:
undetectable		 3aiaA-3qgvA:
19.23
3aiaB-3qgvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.66A 3aicA-3qgvA:
10.7		 3aicA-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.63A 3aicB-3qgvA:
10.7		 3aicB-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
TYR A  62
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
TRS  A 505 (-4.0A)
 0.63A 3aicC-3qgvA:
10.9		 3aicC-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.73A 3aicD-3qgvA:
10.9		 3aicD-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.68A 3aicE-3qgvA:
10.9		 3aicE-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.65A 3aicF-3qgvA:
10.8		 3aicF-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.63A 3aicG-3qgvA:
10.9		 3aicG-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.71A 3aicH-3qgvA:
10.8		 3aicH-3qgvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 GLY A  53
GLY A  61
SER A  22
GLY A  55
GLY A  56
 None
 1.03A 3axzA-3qgvA:
undetectable		 3axzA-3qgvA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLY A 363
GLY A 339
GLY A 357
 None
BCD  A 601 (-3.5A)
None
 0.39A 3bogC-3qgvA:
undetectable		 3bogC-3qgvA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLY A 363
GLY A 339
GLY A 357
 None
BCD  A 601 (-3.5A)
None
 0.40A 3bogD-3qgvA:
undetectable		 3bogD-3qgvA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 GLY A  23
GLY A  24
GLY A  84
THR A  78
 None
CA  A 502 (-4.2A)
CA  A 502 ( 4.4A)
None
 0.63A 3d41A-3qgvA:
undetectable		 3d41A-3qgvA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 TYR A 314
GLU A 318
TYR A  17
ILE A  47
 None
 1.09A 3jz0B-3qgvA:
undetectable		 3jz0B-3qgvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 10 VAL A 200
VAL A 208
LEU A 212
TRP A 211
GLY A 221
 None
None
SUC  A 702 (-3.7A)
None
None
 1.28A 3ls4H-3qgvA:
undetectable		 3ls4H-3qgvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 6 PHE A 353
VAL A 274
THR A 283
PHE A 302
 None
 1.38A 3ltwA-3qgvA:
undetectable		 3ltwA-3qgvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 LEU A 351
ALA A 301
ILE A 293
ILE A 260
ILE A 368
 None
 1.07A 3s53B-3qgvA:
undetectable		 3s53B-3qgvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 GLY A 338
VAL A  11
GLY A  10
GLY A   9
THR A 283
 BCD  A 601 ( 3.7A)
None
None
BCD  A 601 (-3.7A)
None
 0.73A 3ufnA-3qgvA:
undetectable		 3ufnA-3qgvA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 THR A 311
ILE A  12
SER A  43
ILE A 192
ASP A 106
 None
 1.09A 3vw1D-3qgvA:
undetectable		 3vw1D-3qgvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 5 GLU A 150
ASP A 172
ASN A 142
GLU A 118
 None
 1.33A 3vywD-3qgvA:
undetectable		 3vywD-3qgvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 195
VAL A 220
TRP A 211
 None
 1.24A 3zq8A-3qgvA:
undetectable
3zq8B-3qgvA:
undetectable		 3zq8A-3qgvA:
4.35
3zq8B-3qgvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 214
VAL A 208
TRP A 215
 None
 1.35A 3zq8A-3qgvA:
undetectable
3zq8B-3qgvA:
undetectable		 3zq8A-3qgvA:
4.35
3zq8B-3qgvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 215
VAL A 207
TRP A 214
 None
 1.18A 3zq8A-3qgvA:
undetectable
3zq8B-3qgvA:
undetectable		 3zq8A-3qgvA:
4.35
3zq8B-3qgvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 215
VAL A 208
TRP A 214
 None
 1.36A 3zq8A-3qgvA:
undetectable
3zq8B-3qgvA:
undetectable		 3zq8A-3qgvA:
4.35
3zq8B-3qgvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 TRP A 214
VAL A 208
TRP A 177
 None
 1.17A 3zq8C-3qgvA:
undetectable
3zq8D-3qgvA:
undetectable		 3zq8C-3qgvA:
4.35
3zq8D-3qgvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLU A  72
TYR A  73
SER A 136
 SUC  A 701 (-3.1A)
None
None
 0.99A 4at0A-3qgvA:
undetectable		 4at0A-3qgvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 8 HIS A 111
SER A  51
PHE A  67
ASP A 198
 None
None
None
TRS  A 505 (-2.7A)
 1.09A 4kttA-3qgvA:
undetectable		 4kttA-3qgvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 ASP A 164
TRP A 211
SER A 156
 CA  A 501 (-2.3A)
None
None
 0.67A 4lrhA-3qgvA:
undetectable		 4lrhA-3qgvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 GLY A  53
GLY A  61
SER A  22
GLY A  55
GLY A  56
 None
 1.10A 4yvgA-3qgvA:
undetectable		 4yvgA-3qgvA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 ARG A 196
ASP A 198
GLU A 222
HIS A 288
ASP A 289
 TRS  A 505 (-3.0A)
TRS  A 505 (-2.7A)
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.49A 5csyB-3qgvA:
5.4		 5csyB-3qgvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 ILE A 107
PHE A 197
ILE A 192
VAL A 207
LEU A 212
 None
None
None
None
SUC  A 702 (-3.7A)
 1.21A 5jkwA-3qgvA:
undetectable		 5jkwA-3qgvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 7 LYS A  76
GLY A 114
TRP A 128
TYR A 162
 None
 0.75A 6ag0A-3qgvA:
39.7		 6ag0A-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		6 / 12 TRP A  18
TYR A  62
HIS A 111
ASP A 198
HIS A 288
ASP A 289
 None
TRS  A 505 (-4.0A)
None
TRS  A 505 (-2.7A)
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.47A 6ag0A-3qgvA:
39.7		 6ag0A-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 12 TRP A  18
ASP A 198
TYR A 249
HIS A 288
ASP A 289
 None
TRS  A 505 (-2.7A)
None
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.80A 6ag0C-3qgvA:
39.7		 6ag0C-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		4 / 7 LYS A  76
GLY A 114
TRP A 128
TYR A 162
 None
 0.80A 6ag0C-3qgvA:
39.7		 6ag0C-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 9 THR A 158
GLY A 157
GLY A 202
HIS A 167
VAL A 207
 None
CA  A 501 (-4.5A)
CA  A 501 (-4.0A)
None
None
 1.16A 6gnfA-3qgvA:
undetectable		 6gnfA-3qgvA:
21.02