SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.20A 1mj2B-3qh4A:
undetectable		 1mj2B-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.22A 1mj2D-3qh4A:
undetectable		 1mj2D-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.21A 1mjoB-3qh4A:
undetectable		 1mjoB-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.17A 1mjoA-3qh4A:
undetectable		 1mjoA-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.20A 1mjoD-3qh4A:
undetectable		 1mjoD-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 10 GLU A 259
ALA A 165
PRO A 234
PHE A 256
GLY A  91
 None
 1.32A 1mjqG-3qh4A:
undetectable
1mjqH-3qh4A:
undetectable		 1mjqG-3qh4A:
13.88
1mjqH-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		3 / 3 VAL A 192
ALA A 163
HIS A  88
 None
 0.69A 1q23C-3qh4A:
undetectable		 1q23C-3qh4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		3 / 3 VAL A 192
ALA A 163
HIS A  88
 None
 0.72A 1q23H-3qh4A:
undetectable		 1q23H-3qh4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 9 GLY A  90
GLY A  91
SER A 162
ALA A 163
HIS A 284
 None
 0.85A 2aceA-3qh4A:
4.5		 2aceA-3qh4A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 8 GLY A  90
GLY A  91
ALA A 163
PHE A 256
HIS A 284
 None
 1.35A 2ha4A-3qh4A:
18.0		 2ha4A-3qh4A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 7 GLY A  90
GLY A  91
ALA A 163
HIS A 284
 None
 0.28A 2ha4B-3qh4A:
18.3		 2ha4B-3qh4A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 7 ALA A 165
THR A 166
ALA A 169
ARG A 237
 None
 0.82A 2ql8A-3qh4A:
undetectable
2ql8B-3qh4A:
undetectable		 2ql8A-3qh4A:
19.24
2ql8B-3qh4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 4 GLN A 103
GLN A 303
GLY A 304
HIS A 305
 None
 1.18A 3huoA-3qh4A:
undetectable		 3huoA-3qh4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 12 ILE A 278
ALA A 282
LEU A 299
SER A 161
LEU A 247
 None
 1.32A 3ia4B-3qh4A:
undetectable		 3ia4B-3qh4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 7 GLY A  90
GLY A  91
PHE A 256
HIS A 284
 None
 0.51A 3o9mA-3qh4A:
4.0		 3o9mA-3qh4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 9 ASP A 195
SER A 232
TYR A 263
ASP A 194
ASP A 262
 None
 1.48A 3sfuA-3qh4A:
undetectable		 3sfuA-3qh4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		3 / 3 PRO A 208
ASP A 211
GLU A   6
 None
 0.85A 3v4tC-3qh4A:
undetectable		 3v4tC-3qh4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 HIS A 189
HIS A 284
ASP A 287
SER A 288
 None
 1.34A 4apjA-3qh4A:
undetectable
4apjP-3qh4A:
undetectable		 4apjA-3qh4A:
21.16
4apjP-3qh4A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 12 GLY A 164
THR A  99
ALA A 135
VAL A 118
ALA A 169
 None
 1.28A 4df3A-3qh4A:
2.4		 4df3A-3qh4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 12 GLY A 164
THR A  99
ALA A 135
VAL A 118
ALA A 169
 None
 1.26A 4df3B-3qh4A:
undetectable		 4df3B-3qh4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 12 PHE A 210
ILE A  23
PHE A  25
ALA A 123
GLY A  90
 None
 1.09A 4e1gB-3qh4A:
undetectable		 4e1gB-3qh4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 ASP A 100
SER A 288
ARG A  41
GLU A  48
 None
 0.84A 4eysA-3qh4A:
undetectable		 4eysA-3qh4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		3 / 3 PRO A 129
LEU A 132
HIS A 173
 None
 0.69A 4pevA-3qh4A:
4.7		 4pevA-3qh4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 VAL A  71
ARG A  75
VAL A  85
PHE A 151
 None
 1.31A 5addA-3qh4A:
undetectable
5addB-3qh4A:
undetectable		 5addA-3qh4A:
21.60
5addB-3qh4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 VAL A  71
ARG A  75
VAL A  85
PHE A 151
 None
 1.28A 5adeA-3qh4A:
undetectable
5adeB-3qh4A:
undetectable		 5adeA-3qh4A:
21.60
5adeB-3qh4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 ALA A 209
SER A 162
ASP A 254
PRO A 255
 None
 0.87A 5c6pA-3qh4A:
undetectable		 5c6pA-3qh4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 SER A 200
ASP A 195
ARG A 236
GLY A 235
 None
 0.74A 5cdqA-3qh4A:
undetectable
5cdqC-3qh4A:
undetectable
5cdqD-3qh4A:
3.6		 5cdqA-3qh4A:
18.56
5cdqC-3qh4A:
18.56
5cdqD-3qh4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 ILE A 184
VAL A  84
PRO A  82
ALA A 157
 None
 0.86A 5cu6A-3qh4A:
undetectable		 5cu6A-3qh4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 6 PHE A  92
ALA A 131
HIS A  88
LEU A 122
 None
 1.22A 5dzkg-3qh4A:
2.4
5dzku-3qh4A:
undetectable		 5dzkg-3qh4A:
21.88
5dzku-3qh4A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		4 / 5 PRO A 124
ALA A  93
ILE A  30
LEU A  31
 None
 0.79A 5jncD-3qh4A:
undetectable		 5jncD-3qh4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		5 / 12 ASP A 100
SER A 288
PHE A 300
LEU A 307
LEU A 187
 None
 1.05A 5tudA-3qh4A:
undetectable		 5tudA-3qh4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3qh4 ESTERASE LIPW
(Mycobacterium
marinum) 		6 / 12 ALA A 168
ALA A 159
GLN A 186
LEU A 171
ALA A 172
VAL A  71
 None
 1.29A 5z12C-3qh4A:
undetectable		 5z12C-3qh4A:
13.64