SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3qj4 RENALASE
(Homo
sapiens) 		3 / 3 TRP A  33
ALA A   9
VAL A   7
 None
None
FAD  A 401 (-4.7A)
 0.98A 1bdwA-3qj4A:
undetectable
1bdwB-3qj4A:
undetectable		 1bdwA-3qj4A:
5.37
1bdwB-3qj4A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 12 LEU A  19
ALA A 331
GLY A 302
LEU A 338
PHE A  76
 None
 1.36A 1brpA-3qj4A:
undetectable		 1brpA-3qj4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 5 THR A  66
THR A  64
THR A 320
HIS A  73
 None
 1.42A 1d4fB-3qj4A:
undetectable		 1d4fB-3qj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 1gtnB-3qj4A:
undetectable
1gtnC-3qj4A:
undetectable		 1gtnB-3qj4A:
12.68
1gtnC-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 7 LEU A 335
VAL A 334
VAL A   4
ILE A   6
 None
 0.95A 1t87B-3qj4A:
undetectable		 1t87B-3qj4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 8 ASP A 227
GLY A  59
THR A  55
ILE A 111
 None
FAD  A 401 (-4.1A)
None
None
 0.85A 2dtjA-3qj4A:
undetectable
2dtjB-3qj4A:
undetectable		 2dtjA-3qj4A:
20.17
2dtjB-3qj4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 LEU A  80
MET A  11
THR A  12
LEU A  15
 None
None
FAD  A 401 (-3.8A)
None
 1.08A 2dysA-3qj4A:
undetectable
2dysJ-3qj4A:
undetectable		 2dysA-3qj4A:
19.96
2dysJ-3qj4A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 LEU A  80
MET A  11
THR A  12
LEU A  15
 None
None
FAD  A 401 (-3.8A)
None
 1.05A 2dysN-3qj4A:
undetectable
2dysW-3qj4A:
undetectable		 2dysN-3qj4A:
19.96
2dysW-3qj4A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 LEU A  80
MET A  11
THR A  12
LEU A  15
 None
None
FAD  A 401 (-3.8A)
None
 1.07A 2zxwA-3qj4A:
undetectable
2zxwJ-3qj4A:
undetectable		 2zxwA-3qj4A:
19.96
2zxwJ-3qj4A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 GLN A 183
LEU A 185
GLU A 186
LEU A 167
 None
 0.84A 3h5gA-3qj4A:
undetectable
3h5gC-3qj4A:
undetectable		 3h5gA-3qj4A:
6.14
3h5gC-3qj4A:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3qj4 RENALASE
(Homo
sapiens) 		3 / 3 TRP A  33
ALA A   9
VAL A   7
 None
None
FAD  A 401 (-4.7A)
 0.96A 3l8lA-3qj4A:
undetectable
3l8lB-3qj4A:
undetectable		 3l8lA-3qj4A:
5.37
3l8lB-3qj4A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 VAL A   7
VAL A  32
LEU A 119
GLY A   8
GLY A  10
 FAD  A 401 (-4.7A)
None
None
FAD  A 401 (-3.3A)
FAD  A 401 ( 3.7A)
 1.30A 3ls4H-3qj4A:
undetectable		 3ls4H-3qj4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 11 ASP A 227
ALA A  56
GLY A  59
ALA A  60
LEU A 196
 None
None
FAD  A 401 (-4.1A)
FAD  A 401 (-3.4A)
None
 1.05A 3sm2B-3qj4A:
undetectable		 3sm2B-3qj4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 CYH A  65
THR A  64
ASP A 325
ILE A 328
 None
 1.26A 3w9tB-3qj4A:
undetectable		 3w9tB-3qj4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 12 GLY A   8
GLY A  13
THR A 160
LEU A 159
VAL A 132
 FAD  A 401 (-3.3A)
None
None
None
FAD  A 401 (-4.1A)
 1.18A 4f84A-3qj4A:
2.4		 4f84A-3qj4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 11 ILE A 173
GLN A 168
LEU A 169
VAL A 132
LEU A 159
 None
None
None
FAD  A 401 (-4.1A)
None
 1.08A 4g1bB-3qj4A:
4.4		 4g1bB-3qj4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 9 ILE A 173
GLN A 168
LEU A 169
VAL A 132
LEU A 159
 None
None
None
FAD  A 401 (-4.1A)
None
 1.03A 4g1bC-3qj4A:
4.4		 4g1bC-3qj4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 6 VAL A   4
LEU A  28
LEU A 338
MET A  11
 None
 1.10A 4o1zA-3qj4A:
undetectable		 4o1zA-3qj4A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 8 VAL A 293
GLY A 326
SER A 330
GLY A 302
 None
 0.91A 5e26C-3qj4A:
undetectable
5e26D-3qj4A:
undetectable		 5e26C-3qj4A:
21.45
5e26D-3qj4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eeuF-3qj4A:
undetectable
5eeuG-3qj4A:
undetectable		 5eeuF-3qj4A:
12.68
5eeuG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eevF-3qj4A:
undetectable
5eevG-3qj4A:
undetectable		 5eevF-3qj4A:
12.68
5eevG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eewF-3qj4A:
undetectable
5eewG-3qj4A:
undetectable		 5eewF-3qj4A:
12.68
5eewG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eexF-3qj4A:
undetectable
5eexG-3qj4A:
undetectable		 5eexF-3qj4A:
12.68
5eexG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eeyF-3qj4A:
undetectable
5eeyG-3qj4A:
undetectable		 5eeyF-3qj4A:
12.68
5eeyG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5eezF-3qj4A:
undetectable
5eezG-3qj4A:
undetectable		 5eezF-3qj4A:
12.68
5eezG-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5ef0F-3qj4A:
undetectable
5ef0G-3qj4A:
undetectable		 5ef0F-3qj4A:
12.68
5ef0G-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5ef1F-3qj4A:
undetectable
5ef1G-3qj4A:
undetectable		 5ef1F-3qj4A:
12.68
5ef1G-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5ef2F-3qj4A:
undetectable
5ef2G-3qj4A:
undetectable		 5ef2F-3qj4A:
12.68
5ef2G-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 10 SER A 330
ALA A 331
GLY A   8
THR A 160
ILE A   6
 None
None
FAD  A 401 (-3.3A)
None
None
 1.18A 5ef3F-3qj4A:
undetectable
5ef3G-3qj4A:
undetectable		 5ef3F-3qj4A:
12.68
5ef3G-3qj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3qj4 RENALASE
(Homo
sapiens) 		5 / 12 ILE A 273
VAL A 266
ILE A 221
CYH A 220
PRO A 219
 None
 1.47A 5mlmA-3qj4A:
5.9		 5mlmA-3qj4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 5 LYS A 230
GLN A  61
GLY A  10
ILE A 114
 None
None
FAD  A 401 ( 3.7A)
None
 1.21A 6debB-3qj4A:
undetectable		 6debB-3qj4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 5 TYR A  62
LYS A 230
GLN A  61
GLY A 326
 FAD  A 401 (-4.8A)
None
None
None
 1.34A 6debB-3qj4A:
undetectable		 6debB-3qj4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 5 ARG A  22
ALA A  18
TYR A 118
ILE A 328
 None
 1.12A 6f6sA-3qj4A:
undetectable
6f6sB-3qj4A:
undetectable		 6f6sA-3qj4A:
12.61
6f6sB-3qj4A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3qj4 RENALASE
(Homo
sapiens) 		4 / 5 ARG A  22
ALA A  18
TYR A 118
ILE A 328
 None
 1.02A 6g9bA-3qj4A:
undetectable
6g9bB-3qj4A:
undetectable		 6g9bA-3qj4A:
12.61
6g9bB-3qj4A:
14.97