SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		3 / 3 GLU A  82
ILE A 197
ARG A 105
 None
 0.78A 1cd2A-3qk3A:
undetectable		 1cd2A-3qk3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		5 / 12 SER A  71
SER A  98
LEU A  67
LEU A 101
LYS A  55
 None
 1.24A 1lbcA-3qk3A:
undetectable
1lbcC-3qk3A:
undetectable		 1lbcA-3qk3A:
20.53
1lbcC-3qk3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		3 / 3 PHE A 124
ARG A 127
ASN A 121
 None
 0.93A 1xzxX-3qk3A:
undetectable		 1xzxX-3qk3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		3 / 3 TYR A 178
GLN A  78
TRP A 181
 None
 0.96A 4kn2C-3qk3A:
undetectable		 4kn2C-3qk3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		4 / 6 CYH A  45
LEU A 104
CYH A  39
LEU A  28
 None
 1.11A 5hpuC-3qk3A:
undetectable
5hpuD-3qk3A:
undetectable		 5hpuC-3qk3A:
8.02
5hpuD-3qk3A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens) 		3 / 3 THR A 157
HIS A 114
ASN A 155
 None
None
SO4  A   2 (-4.9A)
 0.94A 5n4tA-3qk3A:
undetectable		 5n4tA-3qk3A:
22.67