SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 TYR A 245
ILE A  13
HIS A 156
LEU A 218
 UDP  A 400 (-4.7A)
None
UDP  A 400 (-4.9A)
None
 1.09A 1j96B-3qkwA:
undetectable		 1j96B-3qkwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		5 / 12 TYR A 238
LEU A 105
ILE A 118
MET A 143
MET A 134
 None
 1.16A 2xkwA-3qkwA:
undetectable		 2xkwA-3qkwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 ALA A 165
TYR A 296
ILE A 255
HIS A 172
 None
 1.14A 2zm7A-3qkwA:
undetectable		 2zm7A-3qkwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 VAL A  27
ILE A  69
GLN A  71
LEU A  62
 None
 0.73A 3bjwB-3qkwA:
undetectable		 3bjwB-3qkwA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 VAL A  27
ILE A  69
GLN A  71
LEU A  62
 None
 0.68A 3bjwF-3qkwA:
undetectable		 3bjwF-3qkwA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 VAL A  27
ILE A  69
GLN A  71
LEU A  62
 None
 0.67A 3bjwH-3qkwA:
undetectable		 3bjwH-3qkwA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		5 / 12 THR A  16
LEU A  19
VAL A 229
MET A 153
VAL A 257
 UDP  A 400 (-3.0A)
None
None
None
None
 0.95A 3frqB-3qkwA:
undetectable		 3frqB-3qkwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 6 GLU A 185
ASP A 233
ASP A 235
LYS A 236
 None
 1.41A 3pocB-3qkwA:
undetectable		 3pocB-3qkwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		5 / 12 TYR A 238
LEU A 105
ILE A 118
MET A 143
MET A 134
 None
 1.31A 3qt0A-3qkwA:
undetectable		 3qt0A-3qkwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 7 TYR A 245
ILE A  13
HIS A 156
LEU A 218
 UDP  A 400 (-4.7A)
None
UDP  A 400 (-4.9A)
None
 0.99A 4xo7B-3qkwA:
undetectable		 4xo7B-3qkwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 5 PHE A 315
ILE A 309
MET A 153
ARG A 318
 None
 1.44A 5jm4A-3qkwA:
undetectable		 5jm4A-3qkwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 8 TYR A 120
ASP A  81
THR A  78
THR A  74
 None
 1.26A 5ov9B-3qkwA:
undetectable		 5ov9B-3qkwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		4 / 8 LEU A 167
VAL A 288
ARG A 169
ILE A 171
 None
 0.89A 5v0vA-3qkwA:
undetectable		 5v0vA-3qkwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		5 / 12 TYR A 238
LEU A 105
ILE A 118
MET A 143
MET A 134
 None
 1.09A 5y2tA-3qkwA:
undetectable		 5y2tA-3qkwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN
(Streptococcus
parasanguinis) 		3 / 3 TRP A 186
GLU A 185
GLU A 282
 None
 1.00A 6fhwA-3qkwA:
undetectable		 6fhwA-3qkwA:
15.77