SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		3 / 3 TRP A 265
TYR A 293
LEU A 251
 None
 1.10A 1kxhA-3qltA:
undetectable		 1kxhA-3qltA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		3 / 3 ALA A 295
THR A 101
PHE A   7
 None
 0.58A 2c6nB-3qltA:
undetectable		 2c6nB-3qltA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 8 ASN A  36
LEU A  45
ALA A  29
HIS A 297
 None
 1.01A 3kp6A-3qltA:
undetectable		 3kp6A-3qltA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 8 PRO A 120
ILE A 250
ILE A 344
ARG A 343
 None
 1.11A 3sfeB-3qltA:
undetectable
3sfeC-3qltA:
undetectable		 3sfeB-3qltA:
19.31
3sfeC-3qltA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 LEU A 251
ALA A 232
THR A 253
PHE A 284
 None
 1.19A 3vasB-3qltA:
4.7		 3vasB-3qltA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 THR A 253
THR A 227
HIS A 201
LEU A 233
 None
 1.17A 4lvcA-3qltA:
4.9		 4lvcA-3qltA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 THR A 253
THR A 227
HIS A 201
LEU A 233
 None
 1.18A 4lvcC-3qltA:
5.5		 4lvcC-3qltA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		5 / 12 PHE A 248
GLU A 254
ASN A 252
ILE A 250
PHE A 356
 None
 1.04A 4u8yB-3qltA:
undetectable		 4u8yB-3qltA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		5 / 12 PHE A 248
GLU A 254
ASN A 252
ILE A 250
PHE A 356
 None
 1.04A 4u95B-3qltA:
undetectable		 4u95B-3qltA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		5 / 10 LEU A  68
GLY A  71
SER A 312
ILE A  75
PRO A  97
 None
 1.15A 4xj7C-3qltA:
4.3
4xj7D-3qltA:
3.8		 4xj7C-3qltA:
22.03
4xj7D-3qltA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		3 / 3 SER A  83
GLU A  22
GLU A 202
 None
 0.72A 4ymgB-3qltA:
5.1		 4ymgB-3qltA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 8 LYS A  63
VAL A  87
GLN A  50
GLU A  59
 None
 0.82A 5dqyA-3qltA:
2.6		 5dqyA-3qltA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 8 GLU A 268
GLY A 283
THR A 287
TYR A 293
 None
 0.80A 5flcB-3qltA:
undetectable		 5flcB-3qltA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 8 GLU A 268
GLY A 283
THR A 287
TYR A 293
 None
 0.80A 5flcF-3qltA:
undetectable		 5flcF-3qltA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 LEU A 183
LEU A 184
MET A 203
GLN A 172
 None
 1.32A 5uc3A-3qltA:
undetectable		 5uc3A-3qltA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 THR A 253
THR A 227
HIS A 201
LEU A 233
 None
 1.20A 6gbnA-3qltA:
5.6		 6gbnA-3qltA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2
(Rattus
norvegicus) 		4 / 5 THR A 253
THR A 227
HIS A 201
LEU A 233
 None
 1.25A 6gbnD-3qltA:
5.5		 6gbnD-3qltA:
20.71