SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.12A 1c8lA-3qmlA:
undetectable		 1c8lA-3qmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.07A 1gfzA-3qmlA:
undetectable		 1gfzA-3qmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 203
GLY A 208
ILE A 210
ILE A 116
ILE A 120
 None
 0.78A 1hshB-3qmlA:
undetectable		 1hshB-3qmlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 301
PHE A 290
VAL A 333
 None
 0.75A 1kijA-3qmlA:
undetectable		 1kijA-3qmlA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.08A 1l5qA-3qmlA:
undetectable		 1l5qA-3qmlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.04A 1l7xA-3qmlA:
undetectable		 1l7xA-3qmlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.07A 1l7xB-3qmlA:
undetectable		 1l7xB-3qmlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.86A 1xz1A-3qmlA:
undetectable		 1xz1A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 4 LEU C 248
SER C 249
TYR C 247
LEU C 229
 None
 1.16A 1xz1A-3qmlC:
undetectable		 1xz1A-3qmlC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.86A 1xz3A-3qmlA:
undetectable		 1xz3A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 4 LEU C 248
SER C 249
TYR C 247
LEU C 229
 None
 1.17A 1xz3A-3qmlC:
undetectable		 1xz3A-3qmlC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 244
VAL A 382
PRO A 193
THR A 191
 None
 1.27A 2q6oB-3qmlA:
undetectable		 2q6oB-3qmlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  97
ILE A 116
VAL A 151
VAL A 153
PHE A 160
 None
 0.99A 2ygoA-3qmlA:
undetectable		 2ygoA-3qmlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 SER C 139
GLU C 132
ASP C 147
 None
 0.80A 2zthA-3qmlC:
undetectable		 2zthA-3qmlC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.13A 3bcrA-3qmlA:
undetectable		 3bcrA-3qmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 SER C 139
GLU C 132
ASP C 147
 None
 0.84A 3bwyA-3qmlC:
undetectable		 3bwyA-3qmlC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.10A 3dd1A-3qmlA:
undetectable		 3dd1A-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.07A 3dd1B-3qmlA:
undetectable		 3dd1B-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.09A 3ddsA-3qmlA:
undetectable		 3ddsA-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.07A 3ddsB-3qmlA:
undetectable		 3ddsB-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.10A 3ddwA-3qmlA:
undetectable		 3ddwA-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 197
PHE A 196
ALA A 199
GLY A 121
 None
 1.09A 3ddwB-3qmlA:
undetectable		 3ddwB-3qmlA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.83A 3f33A-3qmlA:
undetectable		 3f33A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 225
ARG C 205
THR C 201
GLU C 194
 None
 1.28A 3ny4A-3qmlC:
undetectable		 3ny4A-3qmlC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.89A 3p50A-3qmlC:
2.6		 3p50A-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.89A 3p50B-3qmlC:
2.6		 3p50B-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.89A 3p50C-3qmlC:
undetectable		 3p50C-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.88A 3p50D-3qmlC:
2.6		 3p50D-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.90A 3p50E-3qmlC:
2.6		 3p50E-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.79A 3ravA-3qmlA:
undetectable		 3ravA-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.78A 3rd0A-3qmlA:
undetectable		 3rd0A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG A 326
LYS C 285
ARG C 205
 None
 1.28A 3w1wA-3qmlA:
undetectable
3w1wB-3qmlA:
undetectable		 3w1wA-3qmlA:
22.48
3w1wB-3qmlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG C 205
ARG A 326
LYS C 285
 None
 1.43A 3w1wA-3qmlC:
undetectable
3w1wB-3qmlC:
undetectable		 3w1wA-3qmlC:
22.80
3w1wB-3qmlC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 151
GLU C 152
SER C 154
 None
 0.68A 4ccqA-3qmlC:
undetectable		 4ccqA-3qmlC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 243
THR A 358
GLU A 396
 None
 0.80A 4df3A-3qmlA:
undetectable		 4df3A-3qmlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 244
LEU C 248
LYS C 245
ASN C 276
 None
 1.11A 4g19A-3qmlC:
2.8		 4g19A-3qmlC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 244
LEU C 248
VAL C 286
TYR C 264
ILE C 293
 None
 1.06A 4g1bD-3qmlC:
undetectable		 4g1bD-3qmlC:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 193
SER A  62
ASP A 115
ILE A 116
ILE A 169
 None
 1.14A 4ktvA-3qmlA:
undetectable
4ktvB-3qmlA:
undetectable		 4ktvA-3qmlA:
22.88
4ktvB-3qmlA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 SER A  62
SER A  86
ASP A 115
ILE A 116
ILE A 169
 None
 0.89A 4ktvA-3qmlA:
undetectable
4ktvB-3qmlA:
undetectable		 4ktvA-3qmlA:
22.88
4ktvB-3qmlA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  63
PRO A  85
ASP A 411
 None
 1.02A 4pm5A-3qmlA:
undetectable		 4pm5A-3qmlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 221
THR A  59
GLY A  58
THR A  60
 None
PO4  A   2 (-4.0A)
PO4  A   2 ( 3.7A)
PO4  A   2 (-3.0A)
 0.92A 4qwpB-3qmlA:
undetectable		 4qwpB-3qmlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 244
PHE C 155
SER C 239
ASP A 330
 None
 1.43A 4rzvB-3qmlC:
undetectable		 4rzvB-3qmlC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 SER C 139
GLU C 132
ASP C 147
 None
 0.85A 4xudA-3qmlC:
undetectable		 4xudA-3qmlC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 VAL A  88
ALA A  89
ASN A 111
GLN A 104
 None
 1.50A 4zgfA-3qmlA:
undetectable		 4zgfA-3qmlA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 313
LYS A 316
ARG A 317
SER A 320
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
 1.04A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		7 / 10 GLU A 313
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.66A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		6 / 10 GLY A 246
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.7A)
None
None
None
None
None
 1.09A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 247
GLY A 275
GLY A 383
SER A 385
ILE A 388
 PO4  A   2 (-3.3A)
PO4  A   4 ( 4.8A)
None
None
None
 0.99A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		8 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.3A)
PO4  A   4 ( 4.8A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.63A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		6 / 10 GLY A 275
GLU A 313
SER A 320
GLY A 384
SER A 385
ARG A 387
 PO4  A   4 ( 4.8A)
PO4  A   4 (-2.9A)
None
None
None
None
 1.38A 5aqfA-3qmlA:
26.6		 5aqfA-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 313
LYS A 316
ARG A 317
SER A 320
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
 1.05A 5aqfC-3qmlA:
26.7		 5aqfC-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		7 / 10 GLU A 313
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.68A 5aqfC-3qmlA:
26.7		 5aqfC-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		7 / 10 GLY A 246
GLY A 275
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.7A)
PO4  A   4 ( 4.8A)
None
None
None
None
None
 1.07A 5aqfC-3qmlA:
26.7		 5aqfC-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		8 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.3A)
PO4  A   4 ( 4.8A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.62A 5aqfC-3qmlA:
26.7		 5aqfC-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		6 / 10 GLY A 275
GLU A 313
SER A 320
GLY A 384
SER A 385
ARG A 387
 PO4  A   4 ( 4.8A)
PO4  A   4 (-2.9A)
None
None
None
None
 1.40A 5aqfC-3qmlA:
26.7		 5aqfC-3qmlA:
64.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		6 / 10 GLU A 313
LYS A 316
ARG A 317
SER A 320
ARG A 387
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
None
 1.14A 5aqyA-3qmlA:
27.2		 5aqyA-3qmlA:
62.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		7 / 10 GLU A 313
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   4 (-2.9A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.65A 5aqyA-3qmlA:
27.2		 5aqyA-3qmlA:
62.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		7 / 10 GLY A 246
GLY A 275
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.7A)
PO4  A   4 ( 4.8A)
None
None
None
None
None
 1.07A 5aqyA-3qmlA:
27.2		 5aqyA-3qmlA:
62.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		8 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 384
SER A 385
ARG A 387
ILE A 388
 PO4  A   2 (-3.3A)
PO4  A   4 ( 4.8A)
PO4  A   4 (-2.9A)
None
None
None
None
None
 0.62A 5aqyA-3qmlA:
27.2		 5aqyA-3qmlA:
62.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 LYS C 166
TYR C 165
GLY A 384
ASP A 244
 None
 1.25A 5emlA-3qmlC:
undetectable		 5emlA-3qmlC:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 247
PRO A 193
THR A 249
THR A  60
 PO4  A   2 (-3.3A)
None
PO4  A   2 ( 4.7A)
PO4  A   2 (-3.0A)
 1.22A 5h5fA-3qmlA:
undetectable		 5h5fA-3qmlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 ALA C 228
ASN C 231
LEU C 232
 None
 0.50A 5i1pD-3qmlC:
undetectable		 5i1pD-3qmlC:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 384
GLY A 383
GLY A 246
GLY A 248
GLY A 274
 None
None
PO4  A   2 (-3.7A)
None
None
 0.80A 6ag0A-3qmlA:
undetectable		 6ag0A-3qmlA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 279
LEU A 394
LEU A 352
GLY A 274
LEU A 273
 PO4  A   4 (-3.2A)
None
None
None
None
 1.04A 6b0iB-3qmlA:
undetectable		 6b0iB-3qmlA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 279
LEU A 394
LEU A 352
GLY A 274
LEU A 273
 PO4  A   4 (-3.2A)
None
None
None
None
 1.09A 6b0lB-3qmlA:
undetectable		 6b0lB-3qmlA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 261
THR C 347
ASN C 350
 None
 0.72A 6baaE-3qmlC:
undetectable		 6baaE-3qmlC:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 261
THR C 347
ASN C 350
 None
 0.72A 6baaF-3qmlC:
undetectable		 6baaF-3qmlC:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 261
THR C 347
ASN C 350
 None
 0.73A 6baaG-3qmlC:
undetectable		 6baaG-3qmlC:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 261
THR C 347
ASN C 350
 None
 0.73A 6baaH-3qmlC:
0.5		 6baaH-3qmlC:
11.22