SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 10 PHE A  38
VAL A 116
VAL A  64
VAL A  62
LEU A  97
 None
 1.16A 1fe2A-3qmwA:
undetectable		 1fe2A-3qmwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.07A 1n13I-3qmwA:
undetectable
1n13L-3qmwA:
undetectable		 1n13I-3qmwA:
10.81
1n13L-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 MET A 108
ARG A  69
ASP A 186
LEU A 183
 None
 1.07A 2qqcB-3qmwA:
undetectable
2qqcC-3qmwA:
undetectable		 2qqcB-3qmwA:
22.03
2qqcC-3qmwA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.03A 2qqcA-3qmwA:
undetectable
2qqcF-3qmwA:
undetectable		 2qqcA-3qmwA:
10.77
2qqcF-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.02A 2qqcG-3qmwA:
undetectable
2qqcJ-3qmwA:
undetectable		 2qqcG-3qmwA:
10.77
2qqcJ-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.03A 2qqcI-3qmwA:
undetectable
2qqcL-3qmwA:
undetectable		 2qqcI-3qmwA:
10.77
2qqcL-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.00A 2qqdA-3qmwA:
undetectable
2qqdE-3qmwA:
undetectable		 2qqdA-3qmwA:
12.61
2qqdE-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  41
GLY A  43
LEU A  66
ASP A 147
GLY A 109
 None
 1.10A 3g2oB-3qmwA:
undetectable		 3g2oB-3qmwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 11 GLY A 105
SER A 134
PHE A 243
GLY A 246
ASN A 240
 None
 1.24A 3v3nA-3qmwA:
1.8		 3v3nA-3qmwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 11 GLY A 105
SER A 134
PHE A 243
GLY A 246
ASN A 240
 None
 1.24A 3v3nD-3qmwA:
undetectable		 3v3nD-3qmwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		4 / 6 ALA A  89
ALA A 125
PRO A 126
THR A  98
 None
 0.94A 4dtzA-3qmwA:
undetectable		 4dtzA-3qmwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 11 PHE A 242
ASP A 213
ALA A 216
ASP A 161
GLY A 163
 None
 1.21A 4xp4A-3qmwA:
undetectable		 4xp4A-3qmwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 109
GLY A 135
SER A 136
ASP A 213
GLY A  42
 None
 1.04A 5hikA-3qmwA:
undetectable		 5hikA-3qmwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 109
GLY A 135
SER A 136
ASP A 213
GLY A  43
 None
 1.10A 5hikA-3qmwA:
undetectable		 5hikA-3qmwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		3 / 3 ARG A 122
HIS A 196
ARG A 198
 None
 0.96A 5iaoC-3qmwA:
undetectable		 5iaoC-3qmwA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		3 / 3 ARG A 122
HIS A 196
ARG A 198
 None
 0.96A 5iaoF-3qmwA:
2.2		 5iaoF-3qmwA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3qmw THIOESTERASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 100
ALA A 125
PRO A 128
ARG A 129
LEU A 103
 None
 1.42A 5syfB-3qmwA:
3.9		 5syfB-3qmwA:
19.62