SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qo7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 5 LEU A 405
PRO A 206
ALA A 272
ILE A 301
 None
 0.74A 2aofB-3qo7A:
undetectable		 2aofB-3qo7A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 12 PHE A 326
TYR A 327
ALA A 356
ALA A 145
TYR A 194
 None
 0.90A 2igtA-3qo7A:
undetectable		 2igtA-3qo7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_B_ADNB1588_1
(ACSD)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 10 LEU A 306
HIS A 399
ARG A 379
LEU A 401
ASN A 372
 None
 1.37A 2w03B-3qo7A:
0.0		 2w03B-3qo7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		3 / 3 SER A 341
GLU A 114
ASP A 118
 None
 0.80A 2zthA-3qo7A:
undetectable		 2zthA-3qo7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 12 LEU A 332
GLY A 331
LEU A 330
ILE A 415
LEU A 425
 None
 1.02A 3gwvA-3qo7A:
undetectable		 3gwvA-3qo7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 7 LEU A 354
TYR A 334
VAL A 426
ILE A 415
 None
 1.21A 3ik3A-3qo7A:
undetectable		 3ik3A-3qo7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 10 PRO A 210
LEU A 207
ILE A 251
PRO A 250
SER A 276
 None
 1.42A 3iluB-3qo7A:
undetectable
3iluE-3qo7A:
undetectable		 3iluB-3qo7A:
19.12
3iluE-3qo7A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 12 ILE A  18
VAL A  32
ILE A  35
ASN A 106
ILE A 105
 None
 1.03A 3kpdB-3qo7A:
undetectable		 3kpdB-3qo7A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 5 PRO A 428
ILE A 427
TYR A 327
TRP A 131
 None
 1.33A 3phaA-3qo7A:
undetectable		 3phaA-3qo7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 7 ASN A 125
GLU A 355
ASP A 121
GLU A 343
 None
 1.21A 4fewB-3qo7A:
undetectable		 4fewB-3qo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 7 ASN A 125
GLY A 338
VAL A 337
PHE A 316
 None
 0.73A 4fglC-3qo7A:
undetectable		 4fglC-3qo7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 8 ASP A 353
ASN A 125
GLU A 355
ASP A 121
 ATP  A 486 (-4.1A)
None
None
None
 1.08A 4gkiE-3qo7A:
undetectable
4gkiG-3qo7A:
undetectable		 4gkiE-3qo7A:
20.87
4gkiG-3qo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		6 / 12 ALA A 356
PRO A 333
GLY A 331
ALA A 407
LYS A 300
GLU A 302
 None
None
None
ATP  A 486 (-3.3A)
ATP  A 486 (-3.1A)
None
 1.15A 5c0oG-3qo7A:
undetectable		 5c0oG-3qo7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		4 / 7 LEU A 401
VAL A 116
TYR A 352
SER A 115
 None
 1.07A 5umwA-3qo7A:
0.6
5umwF-3qo7A:
0.3		 5umwA-3qo7A:
10.59
5umwF-3qo7A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 10 LEU A 191
SER A 406
LEU A 405
ILE A 415
PRO A 428
 None
 1.49A 6dlzB-3qo7A:
6.4
6dlzC-3qo7A:
4.3		 6dlzB-3qo7A:
11.14
6dlzC-3qo7A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		5 / 10 LEU A 191
SER A 406
LEU A 405
ILE A 415
PRO A 428
 None
 1.49A 6dm1B-3qo7A:
6.4
6dm1C-3qo7A:
4.3		 6dm1B-3qo7A:
11.14
6dm1C-3qo7A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Candida
albicans) 		3 / 3 LEU A 199
SER A 197
PHE A 198
 None
 0.67A 6fgcA-3qo7A:
undetectable		 6fgcA-3qo7A:
21.53