SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qoy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		6 / 12 LEU A 140
PRO A 142
GLY A 136
VAL A 128
LEU A 131
GLY A 132
 None
 1.48A 1uakA-3qoyA:
undetectable		 1uakA-3qoyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.12A 1z9hA-3qoyA:
undetectable		 1z9hA-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.13A 1z9hB-3qoyA:
undetectable		 1z9hB-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.12A 1z9hC-3qoyA:
undetectable		 1z9hC-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 THR A 148
PRO A 144
PRO A 178
VAL A 128
VAL A 149
 None
 1.12A 1z9hD-3qoyA:
undetectable		 1z9hD-3qoyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 LEU A 228
ALA A 217
SER A 219
LEU A  30
MET A  33
 None
 1.30A 2aa5A-3qoyA:
undetectable		 2aa5A-3qoyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		3 / 3 ASP A 191
TYR A 194
LYS A 240
 None
 0.88A 2othA-3qoyA:
undetectable		 2othA-3qoyA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		4 / 6 THR A 221
GLU A  43
THR A  44
THR A 113
 None
 0.95A 4pgfA-3qoyA:
undetectable		 4pgfA-3qoyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 12 ALA A 118
GLY A 180
GLY A 139
GLY A 163
VAL A 165
 None
 0.90A 5i73A-3qoyA:
undetectable		 5i73A-3qoyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 11 ALA A 120
THR A 121
GLY A  99
GLY A 100
TYR A  86
 None
 0.94A 5lf3K-3qoyA:
2.9
5lf3L-3qoyA:
undetectable		 5lf3K-3qoyA:
20.08
5lf3L-3qoyA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 11 ALA A 120
THR A 121
GLY A  99
GLY A 100
TYR A  86
 None
 0.94A 5lf3Y-3qoyA:
3.3
5lf3Z-3qoyA:
undetectable		 5lf3Y-3qoyA:
20.08
5lf3Z-3qoyA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3qoy 50S RIBOSOMAL
PROTEIN L1
(Aquifex
aeolicus) 		5 / 9 LEU A 135
ALA A 118
GLY A 139
THR A 221
THR A 146
 None
 1.44A 5w5vA-3qoyA:
undetectable		 5w5vA-3qoyA:
17.33