SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 6 LEU A  40
PHE A  43
ALA A  42
LEU A  76
 None
 0.92A 1ukbA-3qp5A:
undetectable		 1ukbA-3qp5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		5 / 9 THR A 140
LEU A  60
ILE A 150
ILE A 102
GLY A 107
 None
 0.99A 3cv9A-3qp5A:
undetectable		 3cv9A-3qp5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		5 / 12 LEU A  40
ARG A  74
SER A 152
LEU A  58
LEU A  44
 None
 1.16A 3k2hA-3qp5A:
undetectable		 3k2hA-3qp5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 5 SER A  79
ARG A 159
GLY A 138
GLU A 112
 None
 1.06A 3k9fA-3qp5A:
undetectable
3k9fB-3qp5A:
undetectable
3k9fC-3qp5A:
undetectable		 3k9fA-3qp5A:
18.64
3k9fB-3qp5A:
18.64
3k9fC-3qp5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 6 SER A  79
ARG A 159
GLY A 138
GLU A 112
 None
 1.06A 3k9fA-3qp5A:
undetectable
3k9fB-3qp5A:
undetectable
3k9fD-3qp5A:
undetectable		 3k9fA-3qp5A:
18.64
3k9fB-3qp5A:
18.64
3k9fD-3qp5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 5 GLU A 146
LEU A  63
HIS A 179
GLY A 151
 None
 1.12A 3pp1A-3qp5A:
undetectable		 3pp1A-3qp5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		5 / 12 TYR A  88
LEU A  57
ALA A  94
LEU A  72
LEU A  63
 HLC  A 266 (-4.5A)
HLC  A 266 (-4.7A)
None
None
None
 1.34A 3vw1B-3qp5A:
undetectable		 3vw1B-3qp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 5 ARG A 159
GLY A 138
GLU A 112
SER A  79
 None
 1.00A 4z3oA-3qp5A:
undetectable
4z3oB-3qp5A:
undetectable		 4z3oA-3qp5A:
16.94
4z3oB-3qp5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 5 SER A  79
ARG A 159
GLY A 138
GLU A 112
 None
 1.07A 5cdqA-3qp5A:
undetectable
5cdqB-3qp5A:
undetectable
5cdqC-3qp5A:
undetectable		 5cdqA-3qp5A:
19.46
5cdqB-3qp5A:
22.73
5cdqC-3qp5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 5 SER A  79
ARG A 159
GLY A 138
GLU A 112
 None
 1.07A 5cdqR-3qp5A:
undetectable
5cdqS-3qp5A:
undetectable
5cdqT-3qp5A:
undetectable		 5cdqR-3qp5A:
19.46
5cdqS-3qp5A:
22.73
5cdqT-3qp5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 7 TYR A  80
ALA A 130
GLY A 136
ARG A  55
 HLC  A 266 (-4.7A)
HLC  A 266 ( 4.3A)
None
None
 0.87A 5e26A-3qp5A:
undetectable
5e26B-3qp5A:
undetectable		 5e26A-3qp5A:
21.08
5e26B-3qp5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3qp5 CVIR TRANSCRIPTIONAL
REGULATOR
(Chromobacterium
violaceum) 		4 / 4 ASN A  67
LEU A 104
SER A 145
LEU A  60
 None
 1.39A 5kb5A-3qp5A:
undetectable		 5kb5A-3qp5A:
21.71