SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 11 ARG A 214
LEU A 491
GLU A 493
ALA A 476
GLY A 478
None
1.34A 1cmaA-3qp9A:
undetectable
1cmaB-3qp9A:
undetectable
1cmaA-3qp9A:
10.21
1cmaB-3qp9A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 ALA A 247
LEU A 258
LEU A 234
LEU A 285
None
0.96A 1ereE-3qp9A:
undetectable
1ereE-3qp9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 ALA A 247
LEU A 258
LEU A 234
LEU A 285
None
0.96A 1ereF-3qp9A:
undetectable
1ereF-3qp9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 GLY A 478
LEU A 440
LEU A 442
VAL A 470
ALA A 494
None
1.02A 1gseA-3qp9A:
undetectable
1gseA-3qp9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 GLY A 478
LEU A 440
LEU A 442
VAL A 470
ALA A 494
None
0.96A 1gseB-3qp9A:
undetectable
1gseB-3qp9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 VAL A 418
SER A 417
GLY A 392
THR A 398
ALA A 399
None
1.10A 1jg4A-3qp9A:
3.1
1jg4A-3qp9A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ASP A 462
LEU A 458
ILE A 467
ARG A   8
None
1.01A 1mt1A-3qp9A:
undetectable
1mt1F-3qp9A:
undetectable
1mt1A-3qp9A:
5.92
1mt1F-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ILE A 467
ARG A   8
ASP A 462
LEU A 458
None
0.98A 1mt1B-3qp9A:
undetectable
1mt1C-3qp9A:
undetectable
1mt1B-3qp9A:
11.72
1mt1C-3qp9A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 ASP A 462
LEU A 458
ILE A 467
ARG A   8
None
1.00A 1n13I-3qp9A:
undetectable
1n13L-3qp9A:
undetectable
1n13I-3qp9A:
5.92
1n13L-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 LEU A 175
THR A 189
VAL A 190
ALA A  49
ALA A  53
None
1.10A 1n5xA-3qp9A:
undetectable
1n5xA-3qp9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 LEU A 175
THR A 189
VAL A 190
ALA A  49
ALA A  53
None
1.10A 1n5xB-3qp9A:
undetectable
1n5xB-3qp9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 ALA A 351
THR A 350
VAL A 349
HIS A 100
ALA A 344
None
1.08A 1r55A-3qp9A:
undetectable
1r55A-3qp9A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 11 ALA A 324
LEU A 234
LEU A 250
LEU A 258
THR A 236
None
1.20A 1tz8A-3qp9A:
undetectable
1tz8B-3qp9A:
undetectable
1tz8A-3qp9A:
13.74
1tz8B-3qp9A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.98A 1v54A-3qp9A:
undetectable
1v54J-3qp9A:
undetectable
1v54A-3qp9A:
22.76
1v54J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 VAL A 382
ASP A 402
PRO A 422
LEU A 442
None
0.94A 1z2bB-3qp9A:
4.3
1z2bB-3qp9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 ALA A 244
ALA A 247
LEU A 258
LEU A 289
ALA A 296
None
0.97A 2bxgB-3qp9A:
undetectable
2bxgB-3qp9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.95A 2dyrA-3qp9A:
undetectable
2dyrJ-3qp9A:
undetectable
2dyrA-3qp9A:
22.76
2dyrJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.00A 2dysA-3qp9A:
undetectable
2dysJ-3qp9A:
undetectable
2dysA-3qp9A:
22.76
2dysJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.05A 2dysN-3qp9A:
undetectable
2dysW-3qp9A:
undetectable
2dysN-3qp9A:
22.76
2dysW-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 THR A 189
VAL A 190
LEU A 191
ALA A  53
None
0.92A 2e1qA-3qp9A:
undetectable
2e1qA-3qp9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 THR A 189
VAL A 190
LEU A 191
ALA A  53
None
0.86A 2e1qC-3qp9A:
undetectable
2e1qC-3qp9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 LEU A 121
VAL A 126
GLY A 125
LEU A 117
LEU A  71
None
0.74A 2egvA-3qp9A:
undetectable
2egvA-3qp9A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 LEU A 121
VAL A 126
GLY A 125
LEU A 117
LEU A  71
None
0.72A 2egvB-3qp9A:
undetectable
2egvB-3qp9A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.01A 2eijA-3qp9A:
undetectable
2eijJ-3qp9A:
undetectable
2eijA-3qp9A:
22.76
2eijJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.99A 2eilA-3qp9A:
undetectable
2eilJ-3qp9A:
undetectable
2eilA-3qp9A:
22.76
2eilJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.02A 2eimJ-3qp9A:
undetectable
2eimJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.01A 2eimW-3qp9A:
undetectable
2eimW-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.99A 2einN-3qp9A:
undetectable
2einW-3qp9A:
undetectable
2einN-3qp9A:
22.76
2einW-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 PHE A 475
ALA A 383
GLY A 388
LEU A 488
LEU A 491
None
0.98A 2hw2A-3qp9A:
undetectable
2hw2A-3qp9A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 ILE A  11
TRP A 472
PHE A 475
VAL A 470
ALA A 468
None
1.39A 2jj8D-3qp9A:
0.7
2jj8D-3qp9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 ALA A 356
PRO A 149
GLY A 406
LEU A 401
SER A 417
None
1.33A 2nv4A-3qp9A:
undetectable
2nv4A-3qp9A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 ALA A 356
PRO A 149
GLY A 406
LEU A 401
SER A 417
None
1.22A 2nv4B-3qp9A:
undetectable
2nv4B-3qp9A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 ALA A  94
ALA A 179
ALA A 183
ILE A 173
LEU A  50
None
1.21A 2nyrA-3qp9A:
3.0
2nyrA-3qp9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 LEU A 303
LEU A 363
VAL A 316
GLY A 315
None
0.92A 2po5A-3qp9A:
3.1
2po5A-3qp9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 LEU A 303
LEU A 363
VAL A 316
GLY A 315
None
0.97A 2po5B-3qp9A:
3.7
2po5B-3qp9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 ILE A 467
ARG A   8
ASP A 462
LEU A 458
None
0.98A 2qqcB-3qp9A:
undetectable
2qqcC-3qp9A:
undetectable
2qqcB-3qp9A:
11.72
2qqcC-3qp9A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 ASP A 462
LEU A 458
ILE A 467
ARG A   8
None
0.97A 2qqcA-3qp9A:
undetectable
2qqcF-3qp9A:
undetectable
2qqcA-3qp9A:
6.34
2qqcF-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 ASP A 462
LEU A 458
ILE A 467
ARG A   8
None
0.97A 2qqcG-3qp9A:
undetectable
2qqcJ-3qp9A:
undetectable
2qqcG-3qp9A:
6.34
2qqcJ-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 ASP A 462
LEU A 458
ILE A 467
ARG A   8
None
0.98A 2qqcI-3qp9A:
undetectable
2qqcL-3qp9A:
undetectable
2qqcI-3qp9A:
6.34
2qqcL-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 361
PHE A 400
GLN A 407
PRO A 149
None
1.07A 2qqtA-3qp9A:
undetectable
2qqtA-3qp9A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.01A 2zxwA-3qp9A:
undetectable
2zxwJ-3qp9A:
undetectable
2zxwA-3qp9A:
22.76
2zxwJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.98A 3abmA-3qp9A:
undetectable
3abmJ-3qp9A:
undetectable
3abmA-3qp9A:
22.76
3abmJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.93A 3ag1J-3qp9A:
undetectable
3ag1J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
0.93A 3ag1N-3qp9A:
undetectable
3ag1W-3qp9A:
undetectable
3ag1N-3qp9A:
22.76
3ag1W-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.08A 3ag2J-3qp9A:
undetectable
3ag2J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.00A 3ag4J-3qp9A:
undetectable
3ag4J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.05A 3asnA-3qp9A:
undetectable
3asnJ-3qp9A:
undetectable
3asnA-3qp9A:
22.76
3asnJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.01A 3asoA-3qp9A:
undetectable
3asoJ-3qp9A:
undetectable
3asoA-3qp9A:
22.76
3asoJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 THR A 189
VAL A 190
LEU A 191
ALA A  53
None
0.80A 3ax7A-3qp9A:
undetectable
3ax7A-3qp9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 9 THR A 189
VAL A 190
LEU A 191
ALA A  49
ALA A  53
None
1.26A 3ax7B-3qp9A:
undetectable
3ax7B-3qp9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 TYR A 394
ALA A 395
ALA A 419
THR A 466
None
0.91A 3b6hA-3qp9A:
undetectable
3b6hA-3qp9A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
3 / 3 ARG A 168
VAL A 154
THR A 114
None
0.75A 3cyxA-3qp9A:
undetectable
3cyxA-3qp9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 361
PHE A 400
GLN A 407
PRO A 149
None
1.13A 3gclA-3qp9A:
undetectable
3gclA-3qp9A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 HIS A 358
PHE A 400
GLN A 407
PRO A 149
None
1.45A 3gclA-3qp9A:
undetectable
3gclA-3qp9A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 PRO A 374
LEU A 313
ALA A 366
PRO A 413
None
0.94A 3gv1A-3qp9A:
undetectable
3gv1C-3qp9A:
undetectable
3gv1A-3qp9A:
12.48
3gv1C-3qp9A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 LEU A 313
ALA A 366
PRO A 413
PRO A 374
None
0.95A 3gv1A-3qp9A:
undetectable
3gv1B-3qp9A:
undetectable
3gv1A-3qp9A:
12.48
3gv1B-3qp9A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 GLY A 170
GLY A 171
VAL A  86
ASP A  87
LEU A  60
None
1.02A 3m6vA-3qp9A:
5.3
3m6vA-3qp9A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 GLY A 170
GLY A 171
VAL A  86
ASP A  87
LEU A  60
None
1.03A 3m6vB-3qp9A:
5.4
3m6vB-3qp9A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 GLY A 170
GLY A 171
VAL A  86
ASP A  87
LEU A  60
None
1.03A 3m6wA-3qp9A:
5.3
3m6wA-3qp9A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 7 THR A 189
VAL A 190
LEU A 191
ALA A  53
None
0.85A 3uniA-3qp9A:
undetectable
3uniA-3qp9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 LEU A 163
LEU A 498
ALA A 489
ALA A 476
GLY A 485
None
1.21A 4rn6A-3qp9A:
undetectable
4rn6A-3qp9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 7 GLY A 156
GLN A 199
ARG A 210
ALA A 384
ILE A 385
None
1.48A 4txnA-3qp9A:
2.2
4txnA-3qp9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 7 GLY A 156
GLN A 199
ARG A 210
ALA A 384
ILE A 385
None
1.49A 4txnC-3qp9A:
2.7
4txnC-3qp9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 7 GLY A 156
GLN A 199
ARG A 210
ALA A 384
ILE A 385
None
1.49A 4txnD-3qp9A:
2.7
4txnD-3qp9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 ALA A 338
GLU A 164
GLY A 390
GLY A 158
LEU A 115
None
0.99A 4uilH-3qp9A:
undetectable
4uilL-3qp9A:
undetectable
4uilH-3qp9A:
18.03
4uilL-3qp9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 8 ALA A 353
HIS A 327
HIS A 358
THR A 304
None
1.29A 5db5A-3qp9A:
undetectable
5db5B-3qp9A:
undetectable
5db5A-3qp9A:
24.12
5db5B-3qp9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 ALA A 294
ALA A 255
VAL A 233
LEU A 285
VAL A 235
None
1.48A 5eb5B-3qp9A:
undetectable
5eb5B-3qp9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 VAL A  62
LEU A 345
GLY A 112
ALA A 113
LEU A  93
None
1.12A 5iktA-3qp9A:
undetectable
5iktA-3qp9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 12 ALA A  94
GLY A 110
LEU A  92
LEU A 175
ALA A 150
None
1.45A 5jglB-3qp9A:
2.4
5jglB-3qp9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.09A 5w97J-3qp9A:
undetectable
5w97J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.03A 5wauJ-3qp9A:
undetectable
5wauJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.19A 5x19J-3qp9A:
undetectable
5x19J-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.33A 5x1bJ-3qp9A:
undetectable
5x1bJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 5 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.03A 5x1bW-3qp9A:
undetectable
5x1bW-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
4 / 6 ARG A 181
MET A 187
THR A 188
LEU A 191
None
1.02A 5x1fA-3qp9A:
undetectable
5x1fJ-3qp9A:
undetectable
5x1fA-3qp9A:
22.76
5x1fJ-3qp9A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 10 GLY A 387
GLY A 388
ALA A 383
THR A 398
GLY A 156
None
0.98A 6e5zA-3qp9A:
3.5
6e5zA-3qp9A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae)
5 / 11 THR A 236
GLU A 239
ALA A 351
THR A 398
ALA A 419
None
1.47A 6efnA-3qp9A:
2.2
6efnA-3qp9A:
22.49