SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		4 / 5 HIS A 208
GLU A  82
ALA A 201
SER A 123
 None
 1.36A 1errA-3qpbA:
undetectable
1errB-3qpbA:
undetectable		 1errA-3qpbA:
22.11
1errB-3qpbA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1jdvA-3qpbA:
31.6
1jdvD-3qpbA:
31.6		 1jdvA-3qpbA:
31.29
1jdvD-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1jdvB-3qpbA:
31.6
1jdvC-3qpbA:
31.3		 1jdvB-3qpbA:
31.29
1jdvC-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1jdvA-3qpbA:
31.6
1jdvD-3qpbA:
31.6		 1jdvA-3qpbA:
31.29
1jdvD-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 12 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 1jdvE-3qpbA:
31.7
1jdvF-3qpbA:
31.3		 1jdvE-3qpbA:
31.29
1jdvF-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.49A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.45A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.46A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.47A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.48A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.50A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.29A 1pk7A-3qpbA:
31.9		 1pk7A-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 8 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.28A 1pk7B-3qpbA:
32.1		 1pk7B-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pk7C-3qpbA:
32.1		 1pk7C-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9A-3qpbA:
31.8		 1pk9A-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9B-3qpbA:
32.0		 1pk9B-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1pk9C-3qpbA:
32.3		 1pk9C-3qpbA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1pw7A-3qpbA:
31.8		 1pw7A-3qpbA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pw7B-3qpbA:
32.2		 1pw7B-3qpbA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 1vhwB-3qpbA:
32.8
1vhwF-3qpbA:
33.4		 1vhwB-3qpbA:
30.54
1vhwF-3qpbA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.51A 1z35A-3qpbA:
32.7		 1z35A-3qpbA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 9 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1z37A-3qpbA:
32.8		 1z37A-3qpbA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.30A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		4 / 8 THR A  70
ASP A 163
GLU A  83
SER A  78
 None
 1.08A 2zw9A-3qpbA:
undetectable		 2zw9A-3qpbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.42A 3kvrA-3qpbA:
24.6		 3kvrA-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.46A 3kvrB-3qpbA:
24.5		 3kvrB-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  99
GLY A 100
VAL A  95
VAL A 139
LEU A 143
 URA  A1255 (-3.2A)
None
None
None
None
 1.03A 3m6wA-3qpbA:
undetectable		 3m6wA-3qpbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		3 / 3 HIS A 208
SER A  78
GLU A  82
 None
 0.73A 3s8pA-3qpbA:
undetectable		 3s8pA-3qpbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 3u40B-3qpbA:
31.0
3u40C-3qpbA:
30.9		 3u40B-3qpbA:
29.79
3u40C-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.39A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.47A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 3uawA-3qpbA:
31.5		 3uawA-3qpbA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 3uayA-3qpbA:
31.2		 3uayA-3qpbA:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4d9hA-3qpbA:
30.4		 4d9hA-3qpbA:
34.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4da7A-3qpbA:
30.3		 4da7A-3qpbA:
34.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.38A 4danA-3qpbA:
29.9		 4danA-3qpbA:
34.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 4danA-3qpbA:
29.9
4danB-3qpbA:
30.2		 4danA-3qpbA:
34.58
4danB-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 121
THR A 122
GLY A  73
GLU A 120
 None
 1.16A 4v20A-3qpbA:
undetectable		 4v20A-3qpbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 THR A  97
GLY A  73
PRO A  75
SER A  76
ALA A  77
 R1P  A1254 (-3.0A)
None
None
None
None
 1.03A 4ypmA-3qpbA:
undetectable		 4ypmA-3qpbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 202
GLY A  73
GLY A  74
GLY A 121
TYR A 126
 None
 1.10A 6ce2B-3qpbA:
undetectable		 6ce2B-3qpbA:
18.15