SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.39A 1h1dA-3qpfA:
undetectable		 1h1dA-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.38A 1vidA-3qpfA:
undetectable		 1vidA-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ARG A  82
ILE A  85
HIS A  73
LEU A  37
TYR A  33
 None
None
EDO  A 435 (-4.5A)
None
None
 1.18A 2azyA-3qpfA:
undetectable		 2azyA-3qpfA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.37A 2cl5B-3qpfA:
undetectable		 2cl5B-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 104
THR A  40
GLN A  67
 None
 0.67A 2fk8A-3qpfA:
undetectable		 2fk8A-3qpfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 287
LEU A 226
SER A 229
SER A 217
HIS A 177
 None
 1.33A 2hc4A-3qpfA:
undetectable		 2hc4A-3qpfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 424
TYR A 422
LYS A 374
 None
 0.90A 2othA-3qpfA:
undetectable		 2othA-3qpfA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A  81
VAL A   2
THR A  49
VAL A  51
 None
 1.06A 2zaxA-3qpfA:
undetectable		 2zaxA-3qpfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.36A 2zvjA-3qpfA:
undetectable		 2zvjA-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 306
MET A 231
ILE A 297
VAL A 133
VAL A 289
 None
 1.48A 3aqiA-3qpfA:
undetectable		 3aqiA-3qpfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 LEU A 361
ALA A 343
VAL A 397
PRO A 400
 None
 1.16A 3gv1B-3qpfA:
undetectable		 3gv1B-3qpfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ARG A 186
ASP A 193
ASP A 219
PHE A 184
 None
 1.42A 3kivA-3qpfA:
undetectable		 3kivA-3qpfA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A 417
LEU A 420
ASP A 421
 EDO  A 433 ( 4.4A)
EDO  A 435 ( 4.5A)
None
 0.36A 3ko0A-3qpfA:
undetectable		 3ko0A-3qpfA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A 417
LEU A 420
ASP A 421
 EDO  A 433 ( 4.4A)
EDO  A 435 ( 4.5A)
None
 0.31A 3ko0T-3qpfA:
undetectable		 3ko0T-3qpfA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 SER A 217
SER A 349
THR A 351
SER A 348
 None
 1.42A 3loqA-3qpfA:
undetectable		 3loqA-3qpfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 377
GLY A 345
ILE A 329
PHE A 337
ALA A 343
 None
 1.07A 4a6dA-3qpfA:
undetectable		 4a6dA-3qpfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A 300
SER A 217
ASP A 219
GLU A 393
TYR A 338
 None
 1.26A 4dfuB-3qpfA:
0.0		 4dfuB-3qpfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 329
THR A 325
ASP A 299
ILE A 363
GLU A 417
 None
None
None
None
EDO  A 433 ( 4.4A)
 1.36A 4i41A-3qpfA:
undetectable		 4i41A-3qpfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 309
TYR A 311
PHE A 232
VAL A 235
GLY A 313
 None
None
None
EDO  A 436 ( 4.2A)
None
 1.22A 4mm6A-3qpfA:
undetectable		 4mm6A-3qpfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 250
PHE A 160
LEU A 140
PRO A 139
ILE A 243
 None
 0.95A 4p3qA-3qpfA:
undetectable		 4p3qA-3qpfA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A 152
THR A 150
GLN A 155
LEU A 247
 None
 1.46A 4qzuC-3qpfA:
undetectable		 4qzuC-3qpfA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.42A 4xucA-3qpfA:
undetectable		 4xucA-3qpfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TRP A 410
ARG A  62
LEU A 312
 None
 0.94A 5dbyA-3qpfA:
undetectable		 5dbyA-3qpfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.36A 5fhrA-3qpfA:
undetectable		 5fhrA-3qpfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.39A 5fhrB-3qpfA:
undetectable		 5fhrB-3qpfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 287
LEU A 226
SER A 229
SER A 217
HIS A 177
 None
 1.35A 5h1eA-3qpfA:
undetectable		 5h1eA-3qpfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 232
GLN A 141
MET A 414
THR A  65
 None
 1.26A 5u6mA-3qpfA:
undetectable		 5u6mA-3qpfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A  84
THR A  53
GLN A  67
ASP A  55
 None
 1.42A 6ecxA-3qpfA:
undetectable		 6ecxA-3qpfA:
22.92