SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		5 / 9 LEU A 191
VAL A 137
GLY A 193
THR A 195
ASP A 150
 None
None
None
None
ACT  A 402 (-4.0A)
 1.12A 1dz8B-3qphA:
undetectable		 1dz8B-3qphA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		4 / 5 GLU A 173
THR A 154
LEU A 155
LEU A 151
 None
ACT  A 402 (-4.4A)
None
None
 1.20A 1u18B-3qphA:
undetectable		 1u18B-3qphA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		4 / 6 PHE A 144
ILE A 165
VAL A 182
PHE A 180
 None
 0.98A 2cizA-3qphA:
undetectable		 2cizA-3qphA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		4 / 7 THR A 160
MET A 337
ILE A 251
SER A 162
 None
 1.21A 2xytI-3qphA:
undetectable		 2xytI-3qphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		4 / 4 ILE A 223
GLN A 227
VAL A 200
PHE A 216
 None
 1.39A 3ieoA-3qphA:
undetectable		 3ieoA-3qphA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		5 / 12 PHE A 216
GLY A 193
ASP A 150
ILE A 147
LEU A 191
 None
None
ACT  A 402 (-4.0A)
None
None
 1.25A 3iv6A-3qphA:
undetectable		 3iv6A-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		5 / 12 PHE A 216
GLY A 193
ILE A 147
THR A 146
LEU A 191
 None
 1.19A 3iv6A-3qphA:
undetectable		 3iv6A-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		5 / 12 PHE A 216
GLY A 193
ASP A 150
ILE A 147
LEU A 191
 None
None
ACT  A 402 (-4.0A)
None
None
 1.17A 3iv6C-3qphA:
undetectable		 3iv6C-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		5 / 9 PHE A 124
SER A 127
THR A 154
VAL A 161
VAL A 137
 None
GOL  A 411 (-3.9A)
ACT  A 402 (-4.4A)
None
None
 1.35A 4wnvA-3qphA:
undetectable		 4wnvA-3qphA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		3 / 3 THR A  40
SER A  39
TYR A  72
 None
 0.88A 5jsdB-3qphA:
undetectable		 5jsdB-3qphA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		3 / 3 THR A  40
SER A  39
TYR A  72
 None
 0.88A 5jsdC-3qphA:
undetectable		 5jsdC-3qphA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		3 / 3 THR A  40
SER A  39
TYR A  72
 None
 0.87A 5jseA-3qphA:
undetectable		 5jseA-3qphA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		3 / 3 THR A  40
SER A  39
TYR A  72
 None
 0.87A 5jseB-3qphA:
undetectable		 5jseB-3qphA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR
(Pyrococcus
furiosus) 		3 / 3 THR A  40
SER A  39
TYR A  72
 None
 0.87A 5jseC-3qphA:
undetectable		 5jseC-3qphA:
20.22