SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  71
LEU A  72
ALA A 127
ALA A 123
LEU A  37
 None
 1.04A 1fk6A-3qplA:
undetectable		 1fk6A-3qplA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 159
ILE A 211
TRP A 103
GLU A 100
 None
 1.40A 1nsiA-3qplA:
undetectable
1nsiB-3qplA:
1.6		 1nsiA-3qplA:
20.55
1nsiB-3qplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 103
GLU A 100
ARG A 159
ILE A 211
 None
 1.46A 1nsiA-3qplA:
undetectable
1nsiB-3qplA:
1.6		 1nsiA-3qplA:
20.55
1nsiB-3qplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 159
ILE A 211
TRP A 103
GLU A 100
 None
 1.46A 1nsiC-3qplA:
1.9
1nsiD-3qplA:
undetectable		 1nsiC-3qplA:
20.55
1nsiD-3qplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 103
GLU A 100
ARG A 159
ILE A 211
 None
 1.41A 1nsiC-3qplA:
1.9
1nsiD-3qplA:
undetectable		 1nsiC-3qplA:
20.55
1nsiD-3qplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  84
LEU A  87
HIS A 169
 None
 0.78A 1qknA-3qplA:
undetectable		 1qknA-3qplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 194
SER A 186
THR A 202
LEU A 203
 None
 1.22A 3arrA-3qplA:
undetectable		 3arrA-3qplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 159
ILE A 211
TRP A 103
GLU A 100
 None
 1.39A 3e7gA-3qplA:
1.9
3e7gB-3qplA:
1.3		 3e7gA-3qplA:
20.05
3e7gB-3qplA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 103
GLU A 100
ARG A 159
ILE A 211
 None
 1.48A 4nosC-3qplA:
undetectable
4nosD-3qplA:
undetectable		 4nosC-3qplA:
20.00
4nosD-3qplA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		10 / 12 TRP A 103
ILE A 107
PHE A 110
MET A 142
TYR A 148
THR A 149
VAL A 152
ASN A 179
LEU A 183
TRP A 207
 None
 0.55A 5nz0A-3qplA:
29.8		 5nz0A-3qplA:
91.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 148
THR A 149
VAL A 152
LEU A 200
TRP A 207
 None
 1.46A 5nz0A-3qplA:
29.8		 5nz0A-3qplA:
91.10