SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_E_NCAE507_0 (NAD-DEPENDENT DEACETYLASE 2)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 7	PHE A 415 LEU A 414 ASN A 345 ILE A 344	None	0.97A	1yc2E-3qqcA: undetectable	1yc2E-3qqcA: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 5	PRO A 282 ALA A 286 ASP A 94 ASP A 300	None	1.12A	2nyuB-3qqcA: undetectable	2nyuB-3qqcA: 18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	5 / 9	PHE A 415 ILE A 56 ASP A 265 GLY A 421 THR A 152	None	1.15A	2tsrD-3qqcA: undetectable	2tsrD-3qqcA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_A_BEZA1529_0 (BENZOATE-COENZYME A LIGASE)	3qqc	DNA-DIRECTED RNA POLYMERASE, SUBUNIT E'' (Pyrococcus furiosus)	5 / 9	ALA E 57 TYR E 56 ALA E 50 GLY E 49 ILE E 36	None	1.17A	2v7bA-3qqcE: undetectable	2v7bA-3qqcE: 7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_B_BEZB1529_0 (BENZOATE-COENZYME A LIGASE)	3qqc	DNA-DIRECTED RNA POLYMERASE, SUBUNIT E'' (Pyrococcus furiosus)	5 / 9	ALA E 57 TYR E 56 ALA E 50 GLY E 49 ILE E 36	None	1.14A	2v7bB-3qqcE: undetectable	2v7bB-3qqcE: 7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WLK_B_SPMB1302_1 (ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10)	3qqc	DNA-DIRECTED RNA POLYMERASE, SUBUNIT E'' (Pyrococcus furiosus)	4 / 4	ALA E 57 TYR E 56 ALA E 5 TYR E 11	None	1.27A	2wlkA-3qqcE: undetectable 2wlkB-3qqcE: undetectable	2wlkA-3qqcE: 10.77 2wlkB-3qqcE: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB5_0 (FERROCHELATASE)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	3 / 3	PRO A 260 LEU A 261 ARG A 166	None	0.67A	3aqiB-3qqcA: undetectable	3aqiB-3qqcA: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_A_SALA305_1 (TRANSCRIPTIONAL REGULATOR SLYA)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 7	VAL A 340 THR A 341 ILE A 344 THR A 224	None	0.82A	3deuA-3qqcA: undetectable	3deuA-3qqcA: 17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9T_A_BEZA264_0 (ECHA1_1)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 8	ILE A 409 LEU A 51 ALA A 417 ALA A 418	None	0.75A	3r9tA-3qqcA: undetectable	3r9tA-3qqcA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9T_B_BEZB264_0 (ECHA1_1)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 7	ILE A 409 LEU A 51 ALA A 417 ALA A 418	None	0.78A	3r9tB-3qqcA: undetectable	3r9tB-3qqcA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1504_0 (FERROCHELATASE, MITOCHONDRIAL)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 4	PRO A 260 LEU A 261 ILE A 167 ARG A 166	None	1.12A	3w1wA-3qqcA: undetectable	3w1wA-3qqcA: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_A_SAMA1546_0 (CYSTATHIONINE BETA-SYNTHASE)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	5 / 11	LEU A 414 PHE A 415 ALA A 417 THR A 152 ILE A 153	None	1.39A	4uuuA-3qqcA: undetectable 4uuuB-3qqcA: undetectable	4uuuA-3qqcA: 15.90 4uuuB-3qqcA: 15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_C_29SC601_2 (ESTROGEN RECEPTOR)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 6	LEU A 169 ASP A 171 GLU A 172 ILE A 194	None	1.03A	4xi3C-3qqcA: 1.2	4xi3C-3qqcA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XLD_A_BRLA502_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	5 / 12	LEU A 77 PHE A 135 MET A 85 LEU A 365 TYR A 343	None	1.34A	4xldA-3qqcA: undetectable	4xldA-3qqcA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_C_URFC301_1 (BIFUNCTIONAL PROTEIN PYRR)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	3 / 3	ARG A 162 HIS A 240 ARG A 230	None	0.94A	5iaoC-3qqcA: undetectable	5iaoC-3qqcA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_F_URFF301_1 (BIFUNCTIONAL PROTEIN PYRR)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	3 / 3	ARG A 162 HIS A 240 ARG A 230	None	0.91A	5iaoF-3qqcA: undetectable	5iaoF-3qqcA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X80_D_SALD201_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	4 / 5	PRO A 282 GLY A 136 VAL A 284 ARG A 287	None	1.28A	5x80C-3qqcA: undetectable 5x80D-3qqcA: undetectable	5x80C-3qqcA: 16.75 5x80D-3qqcA: 16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	5 / 12	LEU A 77 PHE A 135 MET A 85 LEU A 365 TYR A 343	None	1.25A	5y2oA-3qqcA: undetectable	5y2oA-3qqcA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH3_A_017A101_0 (PROTEASE)	3qqc	DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A'' (Pyrococcus furiosus)	5 / 12	LEU A 279 GLY A 136 GLY A 106 ILE A 309 ILE A 138	None	0.88A	6dh3A-3qqcA: undetectable	6dh3A-3qqcA: 10.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YC2_E_NCAE507_0","NAD-DEPENDENT DEACETYLASE 2","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"PHE A 415;LEU A 414;ASN A 345;ILE A 344","None","0.97A","1yc2E-3qqcA:undetectable","1yc2E-3qqcA:22.30"],["2NYU_B_SAMB201_1","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"PRO A 282;ALA A 286;ASP A  94;ASP A 300","None","1.12A","2nyuB-3qqcA:undetectable","2nyuB-3qqcA:18.41"],["2TSR_D_D16D609_1","THYMIDYLATE SYNTHASE","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",5,"PHE A 415;ILE A  56;ASP A 265;GLY A 421;THR A 152","None","1.15A","2tsrD-3qqcA:undetectable","2tsrD-3qqcA:19.86"],["2V7B_A_BEZA1529_0","BENZOATE-COENZYME A LIGASE","3qqc","DNA-DIRECTED RNA POLYMERASE, SUBUNIT E''","Pyrococcus furiosus",5,"ALA E  57;TYR E  56;ALA E  50;GLY E  49;ILE E  36","None","1.17A","2v7bA-3qqcE:undetectable","2v7bA-3qqcE:7.75"],["2V7B_B_BEZB1529_0","BENZOATE-COENZYME A LIGASE","3qqc","DNA-DIRECTED RNA POLYMERASE, SUBUNIT E''","Pyrococcus furiosus",5,"ALA E  57;TYR E  56;ALA E  50;GLY E  49;ILE E  36","None","1.14A","2v7bB-3qqcE:undetectable","2v7bB-3qqcE:7.75"],["2WLK_B_SPMB1302_1","ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10;ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10","3qqc","DNA-DIRECTED RNA POLYMERASE, SUBUNIT E''","Pyrococcus furiosus",4,"ALA E  57;TYR E  56;ALA E   5;TYR E  11","None","1.27A","2wlkA-3qqcE:undetectable;2wlkB-3qqcE:undetectable","2wlkA-3qqcE:10.77;2wlkB-3qqcE:10.77"],["3AQI_B_CHDB5_0","FERROCHELATASE","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",3,"PRO A 260;LEU A 261;ARG A 166","None","0.67A","3aqiB-3qqcA:undetectable","3aqiB-3qqcA:23.32"],["3DEU_A_SALA305_1","TRANSCRIPTIONAL REGULATOR SLYA","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"VAL A 340;THR A 341;ILE A 344;THR A 224","None","0.82A","3deuA-3qqcA:undetectable","3deuA-3qqcA:17.12"],["3R9T_A_BEZA264_0","ECHA1_1","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"ILE A 409;LEU A  51;ALA A 417;ALA A 418","None","0.75A","3r9tA-3qqcA:undetectable","3r9tA-3qqcA:20.79"],["3R9T_B_BEZB264_0","ECHA1_1","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"ILE A 409;LEU A  51;ALA A 417;ALA A 418","None","0.78A","3r9tB-3qqcA:undetectable","3r9tB-3qqcA:20.79"],["3W1W_A_CHDA1504_0","FERROCHELATASE, MITOCHONDRIAL","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"PRO A 260;LEU A 261;ILE A 167;ARG A 166","None","1.12A","3w1wA-3qqcA:undetectable","3w1wA-3qqcA:22.80"],["4UUU_A_SAMA1546_0","CYSTATHIONINE BETA-SYNTHASE","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",5,"LEU A 414;PHE A 415;ALA A 417;THR A 152;ILE A 153","None","1.39A","4uuuA-3qqcA:undetectable;4uuuB-3qqcA:undetectable","4uuuA-3qqcA:15.90;4uuuB-3qqcA:15.90"],["4XI3_C_29SC601_2","ESTROGEN RECEPTOR","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"LEU A 169;ASP A 171;GLU A 172;ILE A 194","None","1.03A","4xi3C-3qqcA:1.2","4xi3C-3qqcA:18.85"],["4XLD_A_BRLA502_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",5,"LEU A  77;PHE A 135;MET A  85;LEU A 365;TYR A 343","None","1.34A","4xldA-3qqcA:undetectable","4xldA-3qqcA:19.77"],["5IAO_C_URFC301_1","BIFUNCTIONAL PROTEIN PYRR","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",3,"ARG A 162;HIS A 240;ARG A 230","None","0.94A","5iaoC-3qqcA:undetectable","5iaoC-3qqcA:19.73"],["5IAO_F_URFF301_1","BIFUNCTIONAL PROTEIN PYRR","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",3,"ARG A 162;HIS A 240;ARG A 230","None","0.91A","5iaoF-3qqcA:undetectable","5iaoF-3qqcA:19.73"],["5X80_D_SALD201_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887;UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",4,"PRO A 282;GLY A 136;VAL A 284;ARG A 287","None","1.28A","5x80C-3qqcA:undetectable;5x80D-3qqcA:undetectable","5x80C-3qqcA:16.75;5x80D-3qqcA:16.75"],["5Y2O_A_8N6A501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",5,"LEU A  77;PHE A 135;MET A  85;LEU A 365;TYR A 343","None","1.25A","5y2oA-3qqcA:undetectable","5y2oA-3qqcA:12.89"],["6DH3_A_017A101_0","PROTEASE","3qqc","DNA-DIRECTED RNA POLYMERASE SUBUNIT B, DNA-DIRECTED RNA POLYMERASE SUBUNIT A', DNA-DIRECTED RNA POLYMERASE SUBUNIT A''","Pyrococcus furiosus",5,"LEU A 279;GLY A 136;GLY A 106;ILE A 309;ILE A 138","None","0.88A","6dh3A-3qqcA:undetectable","6dh3A-3qqcA:10.70"]]