SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qrx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 9 ILE A  45
LEU A  50
MET A  69
GLU A  72
MET A  89
 None
 0.80A 1ctrA-3qrxA:
13.1		 1ctrA-3qrxA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A  37
ILE A  45
LEU A  50
MET A  54
MET A  69
 None
 0.76A 1dtlA-3qrxA:
12.2		 1dtlA-3qrxA:
41.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A 110
ILE A 118
LEU A 123
LEU A 130
MET A 142
 None
 0.87A 1dtlA-3qrxA:
12.2		 1dtlA-3qrxA:
41.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A 107
ASP A 122
ILE A 118
THR A 119
 None
CA  A 172 (-2.1A)
None
CA  A 172 ( 4.2A)
 0.88A 1hmyA-3qrxA:
undetectable		 1hmyA-3qrxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		6 / 12 ILE A 118
LEU A 123
LEU A 130
MET A 142
ILE A 143
GLU A 145
 None
 1.10A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		7 / 12 PHE A  37
ILE A  45
LEU A  50
LEU A  57
MET A  69
ILE A  70
MET A  89
 None
 1.19A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		6 / 12 PHE A  37
ILE A  45
LEU A  50
LEU A  57
MET A  69
MET A  90
 None
 1.11A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		7 / 12 PHE A  37
ILE A  45
LEU A  50
MET A  54
LEU A  57
MET A  69
ILE A  70
 None
 1.09A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		7 / 12 PHE A  37
LEU A  50
LEU A  57
MET A  69
ILE A  70
GLU A  72
MET A  89
 None
 1.21A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		7 / 12 PHE A  37
LEU A  50
MET A  54
LEU A  57
MET A  69
ILE A  70
GLU A  72
 None
 1.12A 1lxfC-3qrxA:
10.2		 1lxfC-3qrxA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
MELITTIN
(Apis
mellifera;
Chlamydomonas
reinhardtii) 		4 / 5 PHE A 110
LEU B   9
PHE A 159
MET A 163
 None
 1.32A 1wrkB-3qrxA:
11.8		 1wrkB-3qrxA:
42.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A  22
PHE A  37
PHE A  86
MET A  90
 None
 0.68A 1wrlC-3qrxA:
11.6
1wrlD-3qrxA:
11.9		 1wrlC-3qrxA:
42.61
1wrlD-3qrxA:
42.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3qrx CENTRIN
MELITTIN
(Apis
mellifera;
Chlamydomonas
reinhardtii) 		4 / 5 LEU B  13
LEU B  16
LEU A 134
LEU A 123
 None
 0.92A 2ab2B-3qrxB:
undetectable		 2ab2B-3qrxB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3qrx CENTRIN
MELITTIN
(Apis
mellifera;
Chlamydomonas
reinhardtii) 		5 / 12 LEU B  13
LEU B  16
LEU A 134
LEU A 123
GLY A 131
 None
 1.08A 3olsA-3qrxB:
undetectable		 3olsA-3qrxB:
8.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A  37
ILE A  45
LEU A  50
MET A  54
 None
 0.54A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 8 PHE A  37
ILE A  45
LEU A  50
MET A  69
MET A  89
 None
 0.88A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 8 PHE A 110
ILE A 118
LEU A 123
MET A 142
ALA A 146
 None
 0.75A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		5 / 7 PHE A  37
LEU A  50
MET A  69
MET A  89
MET A  90
 None
 0.76A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		4 / 7 PHE A 110
LEU A 123
MET A 142
ALA A 146
 None
 0.99A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 3qrx CENTRIN
(Chlamydomonas
reinhardtii) 		4 / 7 PHE A 110
MET A 142
ALA A 146
MET A 163
 None
 0.65A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17