SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ARG A  78
GLU A 170
GLU A  82
GLU A  79
ARG A   5
 None
GOL  A 232 (-3.5A)
None
CA  A 230 (-3.3A)
None
 1.30A 1jdvA-3qsjA:
undetectable
1jdvD-3qsjA:
undetectable		 1jdvA-3qsjA:
19.92
1jdvD-3qsjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ARG A  78
GLU A 170
GLU A  82
GLU A  79
ARG A   5
 None
GOL  A 232 (-3.5A)
None
CA  A 230 (-3.3A)
None
 1.31A 1jdvB-3qsjA:
undetectable
1jdvC-3qsjA:
undetectable		 1jdvB-3qsjA:
19.92
1jdvC-3qsjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ARG A   5
ARG A  78
GLU A 170
GLU A  82
GLU A  79
 None
None
GOL  A 232 (-3.5A)
None
CA  A 230 (-3.3A)
 1.32A 1jdvA-3qsjA:
undetectable
1jdvD-3qsjA:
undetectable		 1jdvA-3qsjA:
19.92
1jdvD-3qsjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 ARG A  78
GLU A 170
GLU A  82
GLU A  79
ARG A   5
 None
GOL  A 232 (-3.5A)
None
CA  A 230 (-3.3A)
None
 1.31A 1jdvE-3qsjA:
undetectable
1jdvF-3qsjA:
undetectable		 1jdvE-3qsjA:
19.92
1jdvF-3qsjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 126
ALA A 123
LEU A 121
SER A 118
 None
 1.15A 1tt6B-3qsjA:
undetectable		 1tt6B-3qsjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 LEU A 155
ALA A 203
LEU A 201
ALA A 179
 None
 0.95A 2vcvB-3qsjA:
undetectable		 2vcvB-3qsjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A  10
ALA A  81
LEU A 117
LEU A 130
ALA A  76
 None
 0.99A 3dfrA-3qsjA:
undetectable		 3dfrA-3qsjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ILE A 136
ALA A   8
THR A 151
VAL A 200
 None
 0.91A 3me6B-3qsjA:
undetectable		 3me6B-3qsjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 LYS A   6
LEU A  72
ALA A  46
 None
 0.73A 4iizA-3qsjA:
undetectable		 4iizA-3qsjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 117
LEU A 121
ALA A  89
ALA A  81
 None
 0.62A 4z90F-3qsjA:
undetectable
4z90G-3qsjA:
undetectable
4z90H-3qsjA:
undetectable
4z90J-3qsjA:
undetectable		 4z90F-3qsjA:
19.63
4z90G-3qsjA:
19.63
4z90H-3qsjA:
19.63
4z90J-3qsjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ALA A  71
VAL A  74
GLU A  52
LYS A  55
 None
 0.90A 4zbqA-3qsjA:
undetectable		 4zbqA-3qsjA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		4 / 4 LEU A  24
LEU A 161
GLY A 162
GLU A 163
 None
 1.16A 5hhjA-3qsjA:
undetectable		 5hhjA-3qsjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3qsj NUDIX HYDROLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  91
GLY A  93
GLU A  94
 None
 0.63A 6fgdA-3qsjA:
undetectable		 6fgdA-3qsjA:
23.26