SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 ALA A 130
VAL A 264
TRP A 105
None
None
PO4  A 402 (-3.5A)
0.96A 1c4dA-3qt4A:
undetectable
1c4dB-3qt4A:
undetectable
1c4dA-3qt4A:
4.82
1c4dB-3qt4A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 7 VAL A 131
LEU A 145
THR A 143
LEU A 142
None
None
PG4  A 416 ( 4.8A)
None
0.86A 1jgsA-3qt4A:
undetectable
1jgsA-3qt4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 GLY A 161
ASP A 152
ALA A  79
SER A 124
TYR A 187
None
None
PG4  A 413 (-3.6A)
None
PG4  A 414 (-4.6A)
1.23A 1kiaD-3qt4A:
undetectable
1kiaD-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
1.15A 1nbhA-3qt4A:
undetectable
1nbhA-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 GLY A 161
ASP A 152
ALA A  79
SER A 124
TYR A 187
None
None
PG4  A 413 (-3.6A)
None
PG4  A 414 (-4.6A)
1.20A 1nbhC-3qt4A:
undetectable
1nbhC-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
1.15A 1nbhD-3qt4A:
undetectable
1nbhD-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
8 / 10 GLN A 116
GLY A 120
SER A 121
TRP A 123
PHE A 125
SER A 126
HIS A 259
GLY A  77
PO4  A 401 (-3.5A)
PO4  A 401 (-3.1A)
None
None
None
None
PO4  A 401 (-3.6A)
PO4  A 401 ( 2.8A)
0.44A 1stfE-3qt4A:
29.3
1stfI-3qt4A:
undetectable
1stfE-3qt4A:
27.95
1stfI-3qt4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 5 LEU A 239
ASN A 279
VAL A  74
ALA A 235
None
None
PO4  A 401 (-4.1A)
None
1.20A 2cizA-3qt4A:
undetectable
2cizA-3qt4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 THR A 127
ASP A 210
SER A 213
None
0.71A 2nxeA-3qt4A:
undetectable
2nxeA-3qt4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 THR A 127
ASP A 210
SER A 213
None
0.78A 2nxeB-3qt4A:
undetectable
2nxeB-3qt4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 MET A  59
VAL A  53
GLU A  43
PG4  A 415 (-4.6A)
None
None
0.88A 2x9gA-3qt4A:
undetectable
2x9gA-3qt4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 7 GLN A 116
GLY A 120
HIS A 259
TRP A 281
PO4  A 401 (-3.5A)
PO4  A 401 (-3.1A)
PO4  A 401 (-3.6A)
None
0.43A 3ai8A-3qt4A:
25.5
3ai8A-3qt4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 LEU A 145
ALA A 170
ALA A 230
GLY A 133
GLU A 132
None
1.04A 3c6gB-3qt4A:
undetectable
3c6gB-3qt4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 8 VAL A 223
VAL A 110
ILE A 303
GLY A 265
None
0.89A 3hjoA-3qt4A:
undetectable
3hjoA-3qt4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 8 VAL A 223
VAL A 110
ILE A 303
GLY A 265
None
0.90A 3hjoB-3qt4A:
undetectable
3hjoB-3qt4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 ILE A 174
SER A 154
SER A 169
None
0.65A 3iltH-3qt4A:
undetectable
3iltH-3qt4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 ASN A 159
GLY A 260
SER A 124
GLY A 164
LEU A 262
None
PG4  A 413 (-3.5A)
None
None
None
1.18A 3r24A-3qt4A:
undetectable
3r24A-3qt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 TYR A 297
LEU A 262
ARG A 295
PG4  A 411 (-4.1A)
None
None
0.80A 3sufB-3qt4A:
undetectable
3sufB-3qt4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 10 VAL A 263
ILE A 303
GLY A 214
ALA A 222
VAL A 229
None
0.96A 3t3cB-3qt4A:
undetectable
3t3cB-3qt4A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 ASN A 296
GLU A 216
ARG A 295
None
1.05A 3wxoA-3qt4A:
undetectable
3wxoA-3qt4A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 10 TYR A 309
LEU A  99
ALA A 101
ALA A 220
TRP A 105
None
None
None
None
PO4  A 402 (-3.5A)
1.36A 4rn6A-3qt4A:
undetectable
4rn6A-3qt4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 ASN A  87
PHE A 171
TYR A 209
None
0.85A 4u15A-3qt4A:
undetectable
4u15A-3qt4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 4 LYS A 114
ASP A 152
GLU A 182
THR A 128
None
1.39A 5d4uA-3qt4A:
undetectable
5d4uA-3qt4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 4 LYS A 114
ASP A 152
GLU A 182
THR A 128
None
1.41A 5d4uB-3qt4A:
0.0
5d4uB-3qt4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 4 LYS A 114
ASP A 152
GLU A 182
THR A 128
None
1.40A 5d4uC-3qt4A:
0.0
5d4uC-3qt4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 4 LYS A 114
ASP A 152
GLU A 182
THR A 128
None
1.39A 5d4uD-3qt4A:
0.0
5d4uD-3qt4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
5 / 12 LEU A 219
GLY A 302
TRP A 166
SER A 122
GLY A 165
None
None
None
PO4  A 401 ( 2.8A)
None
1.28A 5f9zA-3qt4A:
undetectable
5f9zA-3qt4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 GLY A 207
LEU A  88
HIS A 175
None
0.70A 5u63A-3qt4A:
undetectable
5u63A-3qt4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
3 / 3 GLY A 207
LEU A  88
HIS A 175
None
0.70A 5u63B-3qt4A:
undetectable
5u63B-3qt4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor)
4 / 7 ASP A 249
ASP A 234
GLY A 302
ASN A 300
None
0.89A 5x7pA-3qt4A:
undetectable
5x7pA-3qt4A:
14.82