SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 THR A 276
LEU A 278
GLY A 281
LEU A 354
 None
 0.91A 1gtiA-3qtgA:
undetectable		 1gtiA-3qtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 THR A 276
LEU A 278
GLY A 281
LEU A 354
 None
 1.00A 1gtiD-3qtgA:
undetectable		 1gtiD-3qtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 THR A 276
LEU A 278
GLY A 281
LEU A 354
 None
 0.83A 1gtiE-3qtgA:
undetectable		 1gtiE-3qtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 4 ARG A  60
LEU A  49
ASN A  48
VAL A  57
 None
 1.25A 1lqtA-3qtgA:
undetectable		 1lqtA-3qtgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 4 ARG A  60
LEU A  49
ASN A  48
VAL A  57
 None
 1.25A 1lqtB-3qtgA:
undetectable		 1lqtB-3qtgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 4 ARG A  60
LEU A  49
ASN A  48
VAL A  57
 None
 1.25A 1lquA-3qtgA:
undetectable		 1lquA-3qtgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 4 ARG A  60
LEU A  49
ASN A  48
VAL A  57
 None
 1.25A 1lquB-3qtgA:
undetectable		 1lquB-3qtgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ASP A  43
ILE A 284
ALA A 201
ILE A  78
 None
 0.70A 1n49A-3qtgA:
undetectable		 1n49A-3qtgA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 227
ILE A  61
LEU A  49
VAL A  57
ILE A 190
 None
 0.97A 1oipA-3qtgA:
2.6		 1oipA-3qtgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 307
LEU A 290
HIS A 275
 None
 0.68A 1qknA-3qtgA:
undetectable		 1qknA-3qtgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 218
LEU A 187
SER A 203
ILE A 202
ALA A 201
 None
 1.02A 2bxqA-3qtgA:
undetectable		 2bxqA-3qtgA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.40A 2q64B-3qtgA:
undetectable		 2q64B-3qtgA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.42A 3bvbA-3qtgA:
undetectable		 3bvbA-3qtgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 VAL A 143
LYS A 142
HIS A 260
 None
 0.76A 3elzA-3qtgA:
undetectable		 3elzA-3qtgA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.37A 3em6B-3qtgA:
undetectable		 3em6B-3qtgA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.38A 3jvyB-3qtgA:
undetectable		 3jvyB-3qtgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.43A 3k4vB-3qtgA:
undetectable		 3k4vB-3qtgA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.43A 3k4vC-3qtgA:
undetectable		 3k4vC-3qtgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 1.07A 3nu5B-3qtgA:
undetectable		 3nu5B-3qtgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 10 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 1.04A 3oxwB-3qtgA:
undetectable		 3oxwB-3qtgA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 10 THR A  22
PRO A  25
ARG A  46
ASN A  48
HIS A  51
ALA A 326
 None
 0.47A 3pp7B-3qtgA:
45.8		 3pp7B-3qtgA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.42A 4dqbA-3qtgA:
undetectable		 4dqbA-3qtgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 1.03A 4jecB-3qtgA:
undetectable		 4jecB-3qtgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.87A 4k8cA-3qtgA:
4.0		 4k8cA-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.86A 4kahA-3qtgA:
3.8		 4kahA-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.85A 4kahB-3qtgA:
3.6		 4kahB-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.89A 4kanA-3qtgA:
3.8		 4kanA-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.86A 4kanB-3qtgA:
2.4		 4kanB-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.85A 4kbeA-3qtgA:
3.4		 4kbeA-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.83A 4kbeB-3qtgA:
3.8		 4kbeB-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  83
ARG A  87
ILE A 202
ALA A 205
ASP A  80
 None
 1.14A 4kicA-3qtgA:
undetectable		 4kicA-3qtgA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  47
LEU A 218
VAL A 214
LEU A 187
THR A  22
 None
 1.12A 4km2B-3qtgA:
undetectable		 4km2B-3qtgA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.86A 4lbgA-3qtgA:
2.4		 4lbgA-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 SER A 411
TYR A 199
PRO A 420
 None
 0.87A 4lbgB-3qtgA:
3.7		 4lbgB-3qtgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		3 / 3 LEU A 432
MET A 382
TYR A 400
 None
 0.86A 4p6xG-3qtgA:
undetectable		 4p6xG-3qtgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 11 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.40A 4qgiB-3qtgA:
undetectable		 4qgiB-3qtgA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 THR A 233
ALA A 236
GLY A 255
ALA A 253
THR A 288
 None
 1.24A 4qvnV-3qtgA:
undetectable
4qvnb-3qtgA:
undetectable		 4qvnV-3qtgA:
21.15
4qvnb-3qtgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 THR A 233
ALA A 236
GLY A 255
ALA A 253
THR A 288
 None
 1.24A 4qvnH-3qtgA:
undetectable
4qvnN-3qtgA:
undetectable		 4qvnH-3qtgA:
21.15
4qvnN-3qtgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A  51
GLY A  24
ARG A  60
ASN A  48
 None
 1.15A 4zbqA-3qtgA:
undetectable		 4zbqA-3qtgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 387
ASP A 198
ARG A 410
GLU A  68
 None
 0.85A 5bs8A-3qtgA:
undetectable
5bs8C-3qtgA:
undetectable
5bs8D-3qtgA:
undetectable		 5bs8A-3qtgA:
21.96
5bs8C-3qtgA:
21.96
5bs8D-3qtgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 387
ASP A 198
ARG A 410
GLU A  68
 None
 0.79A 5bs8A-3qtgA:
undetectable
5bs8B-3qtgA:
undetectable
5bs8C-3qtgA:
undetectable		 5bs8A-3qtgA:
21.96
5bs8B-3qtgA:
19.53
5bs8C-3qtgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 387
ASP A 198
ARG A 410
GLU A  68
 None
 0.78A 5btdA-3qtgA:
undetectable
5btdB-3qtgA:
undetectable
5btdC-3qtgA:
undetectable		 5btdA-3qtgA:
21.96
5btdB-3qtgA:
19.53
5btdC-3qtgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 387
ASP A 198
ARG A 410
GLU A  68
 None
 0.82A 5btdA-3qtgA:
undetectable
5btdC-3qtgA:
undetectable
5btdD-3qtgA:
undetectable		 5btdA-3qtgA:
21.96
5btdC-3qtgA:
21.96
5btdD-3qtgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 387
ASP A 198
ARG A 410
GLU A  68
 None
 0.90A 5btgA-3qtgA:
undetectable
5btgC-3qtgA:
undetectable
5btgD-3qtgA:
undetectable		 5btgA-3qtgA:
21.96
5btgC-3qtgA:
21.96
5btgD-3qtgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 187
PHE A 223
SER A 225
VAL A 200
GLY A  24
 None
 1.20A 5f9zB-3qtgA:
3.0		 5f9zB-3qtgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 1.06A 5kqyA-3qtgA:
undetectable		 5kqyA-3qtgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 227
ILE A  61
LEU A  49
VAL A  57
ILE A 190
 None
 0.93A 5mueA-3qtgA:
2.2		 5mueA-3qtgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 1.03A 6dh3B-3qtgA:
undetectable		 6dh3B-3qtgA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
ILE A  47
 None
 0.94A 6dh6B-3qtgA:
undetectable		 6dh6B-3qtgA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.31A 6difB-3qtgA:
undetectable		 6difB-3qtgA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  23
ALA A  52
VAL A  79
ILE A 190
VAL A  45
ILE A  47
 None
 1.34A 6dilB-3qtgA:
undetectable		 6dilB-3qtgA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3qtg PYRUVATE KINASE
(Pyrobaculum
aerophilum) 		5 / 10 SER A 203
GLY A  83
ALA A  50
LEU A  49
LEU A  35
 None
 1.41A 6hqbA-3qtgA:
undetectable
6hqbJ-3qtgA:
undetectable		 6hqbA-3qtgA:
11.06
6hqbJ-3qtgA:
7.85