SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 6 VAL A 344
VAL A 348
ILE A 361
MET A 114
ARG A 331
 None
 1.42A 1iepA-3qtpA:
undetectable		 1iepA-3qtpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 4 SER A 113
VAL A  22
PHE A 384
VAL A 348
 None
 1.43A 1o86A-3qtpA:
undetectable		 1o86A-3qtpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 TYR A 411
ILE A 168
PRO A 170
ALA A 179
 None
 1.00A 1oniD-3qtpA:
undetectable
1oniE-3qtpA:
undetectable		 1oniD-3qtpA:
15.91
1oniE-3qtpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ILE A 116
CYH A 117
ALA A 119
ALA A 120
LEU A 135
 None
 0.82A 1xiuA-3qtpA:
undetectable		 1xiuA-3qtpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 8 LEU A 279
GLY A 278
LYS A 274
LEU A 259
 None
 0.71A 1ya4A-3qtpA:
undetectable		 1ya4A-3qtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 LEU A 279
GLY A 278
LYS A 274
LEU A 259
 None
 0.92A 1ya4B-3qtpA:
undetectable		 1ya4B-3qtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 6 ASN A 433
ILE A 361
GLN A 365
THR A 142
 None
 1.24A 2hkkA-3qtpA:
undetectable		 2hkkA-3qtpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ALA A 228
THR A 186
ALA A 401
ILE A 194
LEU A 161
 None
 1.19A 2nyrA-3qtpA:
undetectable		 2nyrA-3qtpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 GLY A 278
GLY A 287
PHE A 310
PHE A 299
 None
 0.97A 2qwxA-3qtpA:
undetectable
2qwxB-3qtpA:
undetectable		 2qwxA-3qtpA:
18.31
2qwxB-3qtpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 TYR A 286
PHE A 166
MET A 242
ALA A 246
LEU A 259
 None
 1.22A 2x2nD-3qtpA:
undetectable		 2x2nD-3qtpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 10 ILE A 351
GLY A 352
THR A 355
PRO A 329
ILE A  93
 None
 1.35A 2y7wB-3qtpA:
undetectable		 2y7wB-3qtpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ALA A 218
LEU A 161
ILE A 263
GLY A 260
LEU A 259
 None
 1.06A 2yjaB-3qtpA:
undetectable		 2yjaB-3qtpA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 PHE A 358
ILE A 385
VAL A 344
VAL A 332
ILE A 351
 None
 1.14A 3gwxB-3qtpA:
undetectable		 3gwxB-3qtpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 5 LEU A 161
GLY A 217
MET A 242
PHE A 249
 None
 1.31A 3uq6B-3qtpA:
undetectable		 3uq6B-3qtpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 5 LEU A 324
GLY A 321
PHE A 299
ASN A 342
 None
 1.30A 3uq6B-3qtpA:
undetectable		 3uq6B-3qtpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 4 LEU A 161
GLY A 217
MET A 242
PHE A 249
 None
 1.27A 3vaqB-3qtpA:
undetectable		 3vaqB-3qtpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		3 / 3 LYS A 429
THR A 171
ILE A 229
 None
 0.73A 4e0fB-3qtpA:
undetectable		 4e0fB-3qtpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		3 / 3 GLN A   4
THR A  26
THR A  25
 None
 0.79A 4fu9A-3qtpA:
undetectable		 4fu9A-3qtpA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		3 / 3 GLN A   4
THR A  26
THR A  25
 None
 0.76A 4fufA-3qtpA:
undetectable		 4fufA-3qtpA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 8 ILE A  93
ILE A 351
MET A 114
GLY A 111
 None
 0.98A 4hdlA-3qtpA:
undetectable		 4hdlA-3qtpA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 HIS A 138
LEU A 392
ILE A 346
GLU A 366
GLY A 370
 None
 1.24A 4hfpB-3qtpA:
undetectable		 4hfpB-3qtpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 11 ALA A 218
LEU A 161
ILE A 263
GLY A 260
LEU A 259
 None
 1.07A 4pxmB-3qtpA:
undetectable		 4pxmB-3qtpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 8 GLY A 400
GLU A 208
GLU A 296
ALA A 241
 None
2PG  A 437 (-3.0A)
MG  A 441 (-3.3A)
None
 0.89A 4rjdA-3qtpA:
undetectable
4rjdB-3qtpA:
undetectable		 4rjdA-3qtpA:
11.06
4rjdB-3qtpA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.72A 4txnA-3qtpA:
undetectable		 4txnA-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.74A 4txnB-3qtpA:
undetectable		 4txnB-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.73A 4txnC-3qtpA:
undetectable		 4txnC-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.73A 4txnD-3qtpA:
undetectable		 4txnD-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 11 ALA A 218
LEU A 161
ILE A 263
GLY A 260
LEU A 259
 None
 1.04A 5dxbB-3qtpA:
undetectable		 5dxbB-3qtpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ALA A 218
LEU A 161
ILE A 263
GLY A 260
LEU A 259
 None
 0.95A 5gtrA-3qtpA:
undetectable		 5gtrA-3qtpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ILE A  24
ILE A 116
VAL A   6
ASN A 107
ILE A  73
 None
 1.20A 5lg3J-3qtpA:
undetectable		 5lg3J-3qtpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 7 LEU A 135
ILE A 109
THR A 353
MET A  92
 None
 1.47A 5ljcA-3qtpA:
undetectable		 5ljcA-3qtpA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		5 / 12 ARG A 432
ASN A 430
GLY A 172
THR A 171
GLN A 396
 None
 1.26A 5oj0A-3qtpA:
undetectable		 5oj0A-3qtpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 6 ILE A 116
ILE A 346
LEU A 388
PHE A 384
 None
 1.04A 5vkqB-3qtpA:
undetectable
5vkqC-3qtpA:
undetectable		 5vkqB-3qtpA:
13.96
5vkqC-3qtpA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 6 ILE A 116
ILE A 346
LEU A 388
PHE A 384
 None
 1.04A 5vkqC-3qtpA:
undetectable
5vkqD-3qtpA:
undetectable		 5vkqC-3qtpA:
13.96
5vkqD-3qtpA:
13.96