SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 9 GLU A 144
PRO A 116
ALA A 117
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.21A 1aj6A-3qtyA:
undetectable		 1aj6A-3qtyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 8 LEU A 216
GLU A 215
GLU A 217
ILE A 283
 None
 1.11A 1qvtA-3qtyA:
undetectable		 1qvtA-3qtyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 12 ASP A 112
GLU A 144
PRO A 116
ALA A 117
ILE A 118
 None
 1.23A 1s14B-3qtyA:
undetectable		 1s14B-3qtyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 12 MET A 320
PHE A 182
ALA A 312
ILE A 261
ILE A 252
 None
 1.25A 2bjfA-3qtyA:
undetectable		 2bjfA-3qtyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 6 PRO A 146
MET A 145
HIS A 111
ASP A 155
 None
 1.39A 2lh8A-3qtyA:
undetectable		 2lh8A-3qtyA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 6 ILE A 283
ARG A 289
ILE A 293
PHE A 302
 None
 0.73A 2q72A-3qtyA:
undetectable		 2q72A-3qtyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 8 GLY A 270
ALA A 271
THR A 309
ILE A 261
 None
 0.67A 3el0A-3qtyA:
undetectable		 3el0A-3qtyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 7 ILE A 246
PHE A 317
LYS A 319
GLY A 243
 None
 1.12A 3em0B-3qtyA:
undetectable		 3em0B-3qtyA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 12 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.37A 3lpsA-3qtyA:
undetectable		 3lpsA-3qtyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 12 LEU A 265
ARG A 263
PRO A 266
GLY A 270
THR A 339
 None
 1.23A 3okxA-3qtyA:
undetectable		 3okxA-3qtyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 7 ILE A 252
GLY A 307
SER A 186
PHE A 284
 None
 0.84A 3v7pA-3qtyA:
undetectable		 3v7pA-3qtyA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 7 LEU A  60
VAL A  59
PRO A  58
TYR A  46
 None
 1.11A 4lb2A-3qtyA:
undetectable		 4lb2A-3qtyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		3 / 3 PRO A 281
ASN A 303
HIS A 190
 None
 0.87A 4ma3H-3qtyA:
undetectable
4ma3L-3qtyA:
undetectable		 4ma3H-3qtyA:
21.41
4ma3L-3qtyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 4 ALA A 110
VAL A 157
GLY A  68
THR A  71
 None
None
SO4  A 400 (-3.5A)
None
 0.82A 4ubeA-3qtyA:
undetectable		 4ubeA-3qtyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 11 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.23A 4urnB-3qtyA:
undetectable		 4urnB-3qtyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 11 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.26A 4urnC-3qtyA:
undetectable		 4urnC-3qtyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		3 / 3 MET A  23
ASP A 107
PHE A  88
 POP  A 404 ( 3.9A)
POP  A 404 (-2.6A)
None
 1.01A 4xeyA-3qtyA:
undetectable		 4xeyA-3qtyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		3 / 3 PRO A 281
ILE A 347
SER A 187
 None
 0.58A 5fsaA-3qtyA:
undetectable		 5fsaA-3qtyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 5 PHE A 239
ILE A 310
MET A 320
GLN A 321
 None
 1.17A 5jm4A-3qtyA:
undetectable		 5jm4A-3qtyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		3 / 3 THR A 161
PRO A  58
ARG A 166
 None
 0.82A 5nd7B-3qtyA:
undetectable		 5nd7B-3qtyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ASN A 303
TYR A 194
VAL A  67
LEU A  83
 None
SO4  A 400 (-4.9A)
None
None
 1.15A 6a7pA-3qtyA:
undetectable		 6a7pA-3qtyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		4 / 6 VAL A  73
LEU A 225
LEU A 189
LEU A 200
 None
 1.07A 6f6sA-3qtyA:
undetectable
6f6sB-3qtyA:
undetectable		 6f6sA-3qtyA:
14.12
6f6sB-3qtyA:
11.71