SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 VAL A 238
LEU A 209
SER A 207
LEU A 211
 None
 0.83A 1j8uA-3qv2A:
undetectable		 1j8uA-3qv2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 ILE A 159
PHE A 307
ILE A 277
PRO A 156
 None
 0.96A 1oniB-3qv2A:
undetectable
1oniC-3qv2A:
undetectable		 1oniB-3qv2A:
15.29
1oniC-3qv2A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 TYR A 169
GLU A  10
SER A  21
VAL A 308
 None
 1.01A 1tv8A-3qv2A:
undetectable		 1tv8A-3qv2A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 8 TYR A 169
GLU A  10
SER A  21
VAL A 308
 None
 1.03A 2fb2A-3qv2A:
undetectable		 2fb2A-3qv2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 TYR A 169
GLU A  10
SER A  21
VAL A 308
 None
 1.03A 2fb2B-3qv2A:
undetectable		 2fb2B-3qv2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 5 ILE A  34
PRO A  35
PHE A  11
ILE A  67
 None
 1.08A 2hjhA-3qv2A:
3.1		 2hjhA-3qv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 PHE A  12
GLY A  14
GLY A  17
PRO A  80
VAL A 304
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
SAH  A 323 (-4.4A)
SAH  A 323 ( 4.4A)
 0.40A 2hmyB-3qv2A:
26.6		 2hmyB-3qv2A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 11 GLY A  16
GLU A  10
ASN A  43
ALA A  42
GLU A  23
 SAH  A 323 ( 4.7A)
None
None
SAH  A 323 ( 4.8A)
None
 1.28A 2vdvF-3qv2A:
7.0		 2vdvF-3qv2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 ILE A 309
GLY A  14
GLY A  17
ASN A  58
PRO A  80
 None
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
SAH  A 323 (-3.1A)
SAH  A 323 (-4.4A)
 1.00A 2y7hB-3qv2A:
5.8		 2y7hB-3qv2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 PHE A  12
GLY A  14
GLY A  17
LEU A  18
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
None
SAH  A 323 (-4.4A)
 0.81A 3av6A-3qv2A:
14.6		 3av6A-3qv2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		6 / 12 PHE A  12
GLY A  14
GLY A  17
PRO A  80
ASN A 302
VAL A 304
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
SAH  A 323 (-4.4A)
None
SAH  A 323 ( 4.4A)
 0.95A 3av6A-3qv2A:
14.6		 3av6A-3qv2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 10 PHE A  12
ASP A  37
ILE A  38
ASN A  39
ALA A  42
 SAH  A 323 (-4.4A)
SAH  A 323 (-2.9A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 ( 4.8A)
 0.67A 3ay0A-3qv2A:
7.0		 3ay0A-3qv2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 10 PHE A  12
GLY A  14
ASP A  37
ILE A  38
ASN A  39
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-2.9A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
 0.62A 3ay0B-3qv2A:
7.0		 3ay0B-3qv2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 PHE A 129
VAL A 134
ILE A 138
SER A 102
 None
None
None
SAH  A 323 ( 4.2A)
 1.00A 3pglA-3qv2A:
2.6		 3pglA-3qv2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 5 TYR A 245
ILE A 244
ASN A 265
ILE A 219
 None
 0.98A 4jtpA-3qv2A:
undetectable		 4jtpA-3qv2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 PHE A  12
GLY A  14
ILE A  38
ASN A  39
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
 0.92A 4rtmA-3qv2A:
undetectable		 4rtmA-3qv2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 PHE A  12
GLY A  14
ILE A  38
ASN A  39
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
 0.90A 4rtpA-3qv2A:
6.1		 4rtpA-3qv2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 11 PHE A  12
ASP A  37
ILE A  38
ASN A  39
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-2.9A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
 0.79A 4rtrA-3qv2A:
5.6		 4rtrA-3qv2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		6 / 12 PHE A  12
GLY A  14
ASP A  37
ILE A  38
ASN A  39
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-2.9A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
 0.87A 4rtsA-3qv2A:
6.1		 4rtsA-3qv2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		3 / 3 ASP A 293
SER A 202
TYR A 203
 None
 0.86A 5glmA-3qv2A:
undetectable		 5glmA-3qv2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 11 PHE A  12
GLY A  14
ILE A  38
ASN A  39
PRO A  80
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
 0.74A 5hjiA-3qv2A:
8.3		 5hjiA-3qv2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		3 / 3 GLY A  14
ASP A  37
ASN A  58
 SAH  A 323 (-3.6A)
SAH  A 323 (-2.9A)
SAH  A 323 (-3.1A)
 0.43A 5jglA-3qv2A:
9.9		 5jglA-3qv2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		3 / 3 HIS A 278
SER A 305
ARG A 167
 None
 0.98A 5u63A-3qv2A:
2.7		 5u63A-3qv2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 6 ALA A 100
PRO A  79
ASP A  97
TYR A  84
 None
 1.06A 5umd2-3qv2A:
undetectable
5umdF-3qv2A:
undetectable		 5umd2-3qv2A:
14.20
5umdF-3qv2A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 5 MET A 313
ASN A 125
VAL A 170
LEU A 316
 None
 1.42A 5xdhB-3qv2A:
undetectable		 5xdhB-3qv2A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 TYR A 107
TRP A  75
TYR A 147
LEU A 114
 None
 1.34A 6cnjA-3qv2A:
0.0
6cnjB-3qv2A:
0.0		 6cnjA-3qv2A:
12.69
6cnjB-3qv2A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 8 TYR A 107
TRP A  75
TYR A 147
LEU A 114
 None
 1.34A 6cnjD-3qv2A:
undetectable
6cnjE-3qv2A:
undetectable		 6cnjD-3qv2A:
12.69
6cnjE-3qv2A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 7 TYR A 107
TRP A  75
TYR A 147
LEU A 114
 None
 1.36A 6cnkB-3qv2A:
undetectable
6cnkC-3qv2A:
undetectable		 6cnkB-3qv2A:
12.69
6cnkC-3qv2A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 PHE A  12
GLY A  14
GLY A  17
ASN A 302
VAL A 304
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
None
SAH  A 323 ( 4.4A)
 0.52A 6mhtA-3qv2A:
28.0		 6mhtA-3qv2A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE
(Entamoeba
histolytica) 		6 / 12 PHE A  12
GLY A  17
ASP A  60
ASN A 302
SER A 303
VAL A 304
 SAH  A 323 (-4.4A)
SAH  A 323 (-3.0A)
SAH  A 323 (-3.5A)
None
None
SAH  A 323 ( 4.4A)
 1.43A 6mhtA-3qv2A:
28.0		 6mhtA-3qv2A:
27.02