SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 LEU A 151
CYH A 178
GLY A 147
LEU A 102
 None
 0.97A 1jlbA-3qv9A:
undetectable		 1jlbA-3qv9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 6 HIS A  58
PHE A  53
GLY A 201
LYS A 199
 None
 1.40A 2i30A-3qv9A:
undetectable		 2i30A-3qv9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		3 / 3 VAL A 153
LYS A 152
HIS A 243
 None
 0.86A 3elzA-3qv9A:
undetectable		 3elzA-3qv9A:
15.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		8 / 10 THR A  27
ARG A  50
ASN A  52
HIS A  55
GLY A  56
GLY A 332
ALA A 335
LYS A 336
 PO4  A 501 (-3.5A)
PO4  A 501 (-3.7A)
K  A 500 ( 3.5A)
None
None
PO4  A 501 (-3.6A)
PO4  A 501 (-3.6A)
PO4  A 501 ( 4.9A)
 1.24A 3pp7B-3qv9A:
69.2		 3pp7B-3qv9A:
75.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		9 / 10 THR A  27
PRO A  30
ARG A  50
ASN A  52
GLY A  56
TYR A  60
GLY A 332
ALA A 335
LYS A 336
 PO4  A 501 (-3.5A)
None
PO4  A 501 (-3.7A)
K  A 500 ( 3.5A)
None
None
PO4  A 501 (-3.6A)
PO4  A 501 (-3.6A)
PO4  A 501 ( 4.9A)
 0.60A 3pp7B-3qv9A:
69.2		 3pp7B-3qv9A:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 6 SER A 437
ALA A  21
ARG A 414
LEU A 397
 None
 0.97A 3ravA-3qv9A:
undetectable		 3ravA-3qv9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 11 SER A 284
ILE A 283
VAL A 293
VAL A 261
ILE A 253
 None
 1.22A 3rf4A-3qv9A:
undetectable
3rf4C-3qv9A:
undetectable		 3rf4A-3qv9A:
12.13
3rf4C-3qv9A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 11 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.24A 3rf4A-3qv9A:
undetectable
3rf4B-3qv9A:
undetectable		 3rf4A-3qv9A:
12.13
3rf4B-3qv9A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 11 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.25A 3rf4B-3qv9A:
undetectable
3rf4C-3qv9A:
undetectable		 3rf4B-3qv9A:
12.13
3rf4C-3qv9A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 GLY A 245
GLN A 247
ASN A 248
HIS A 243
 None
 1.00A 4wryA-3qv9A:
undetectable		 4wryA-3qv9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 GLY A 245
GLN A 247
ASN A 248
HIS A 243
 None
 1.00A 4wrzA-3qv9A:
undetectable		 4wrzA-3qv9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 12 GLY A 488
GLU A 378
CYH A 382
ALA A 407
HIS A 481
 None
 1.27A 5arfA-3qv9A:
undetectable		 5arfA-3qv9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 7 ILE A 206
THR A  64
ILE A  65
LEU A  83
 None
 0.74A 5fukA-3qv9A:
undetectable
5fukB-3qv9A:
undetectable		 5fukA-3qv9A:
18.85
5fukB-3qv9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 12 ALA A 296
SER A 302
THR A 310
GLU A 333
SER A 331
 None
None
None
None
PO4  A 501 (-4.3A)
 1.23A 5hfjE-3qv9A:
2.0		 5hfjE-3qv9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 THR A 424
THR A 428
ARG A 427
GLN A 431
 None
 1.37A 5tzoA-3qv9A:
undetectable		 5tzoA-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 THR A 424
THR A 428
ARG A 427
GLN A 431
 None
 1.39A 5tzoB-3qv9A:
undetectable		 5tzoB-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		4 / 8 THR A 424
THR A 428
ARG A 427
GLN A 431
 None
 1.38A 5tzoC-3qv9A:
undetectable		 5tzoC-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3qv9 PYRUVATE KINASE 2
(Trypanosoma
cruzi) 		5 / 12 ALA A  72
LEU A  38
SER A 331
VAL A 343
LEU A  81
 None
None
PO4  A 501 (-4.3A)
None
None
 1.12A 6djzC-3qv9A:
undetectable		 6djzC-3qv9A:
18.87