SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8D_A_BEZA1001_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 6	VAL A 328 SER A 310 LEU A 280 HIS A 300	None	1.33A	2f8dA-3qveA: undetectable	2f8dA-3qveA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TNE_A_RITA401_2 (SECRETED ASPARTIC PROTEASE)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 6	PRO A 314 SER A -1 TYR A 303 THR A 317	EDO A 343 (-4.1A) None EDO A 40 (-4.6A) None	1.07A	3tneA-3qveA: undetectable	3tneA-3qveA: 17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJT_D_017D101_2 (PROTEASE)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 9	LEU A 265 ASP A 283 GLY A 285 ASP A 260 VAL A 333	None EDO A 13 (-4.9A) EDO A 13 (-3.6A) None EDO A 13 ( 4.6A)	1.18A	4njtD-3qveA: undetectable	4njtD-3qveA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_B_SAMB2409_1 (RNA-DIRECTED RNA POLYMERASE L)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 6	GLY A 261 ASP A 283 ASP A 332 ASP A 260	EDO A 13 (-4.4A) EDO A 13 (-4.9A) None None	0.99A	4uckB-3qveA: undetectable	4uckB-3qveA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_A_BZMA301_0 (ISATIN HYDROLASE A)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	6 / 12	TRP A 212 VAL A 333 GLY A 261 GLY A 285 TYR A 257 HIS A 213	None EDO A 13 ( 4.6A) EDO A 13 (-4.4A) EDO A 13 (-3.6A) None None	1.25A	5nnaA-3qveA: undetectable	5nnaA-3qveA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_B_BZMB301_0 (ISATIN HYDROLASE A)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	6 / 12	TRP A 212 VAL A 333 GLY A 261 GLY A 285 TYR A 257 HIS A 213	None EDO A 13 ( 4.6A) EDO A 13 (-4.4A) EDO A 13 (-3.6A) None None	1.24A	5nnaB-3qveA: undetectable	5nnaB-3qveA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_C_BZMC301_0 (ISATIN HYDROLASE A)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	6 / 12	TRP A 212 VAL A 333 GLY A 261 GLY A 285 TYR A 257 HIS A 213	None EDO A 13 ( 4.6A) EDO A 13 (-4.4A) EDO A 13 (-3.6A) None None	1.25A	5nnaC-3qveA: undetectable	5nnaC-3qveA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_D_BZMD301_0 (ISATIN HYDROLASE A)	3qve	HMG BOX-CONTAINING PROTEIN 1 (Homo sapiens)	6 / 12	TRP A 212 VAL A 333 GLY A 261 GLY A 285 TYR A 257 HIS A 213	None EDO A 13 ( 4.6A) EDO A 13 (-4.4A) EDO A 13 (-3.6A) None None	1.26A	5nnaD-3qveA: undetectable	5nnaD-3qveA: 17.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2F8D_A_BEZA1001_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",4,"VAL A 328;SER A 310;LEU A 280;HIS A 300","None","1.33A","2f8dA-3qveA:undetectable","2f8dA-3qveA:19.83"],["3TNE_A_RITA401_2","SECRETED ASPARTIC PROTEASE","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",4,"PRO A 314;SER A  -1;TYR A 303;THR A 317","EDO A 343 (-4.1A);None;EDO A  40 (-4.6A);None","1.07A","3tneA-3qveA:undetectable","3tneA-3qveA:17.55"],["4NJT_D_017D101_2","PROTEASE","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",5,"LEU A 265;ASP A 283;GLY A 285;ASP A 260;VAL A 333","None;EDO A  13 (-4.9A);EDO A  13 (-3.6A);None;EDO A  13 ( 4.6A)","1.18A","4njtD-3qveA:undetectable","4njtD-3qveA:16.44"],["4UCK_B_SAMB2409_1","RNA-DIRECTED RNA POLYMERASE L","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",4,"GLY A 261;ASP A 283;ASP A 332;ASP A 260","EDO A  13 (-4.4A);EDO A  13 (-4.9A);None;None","0.99A","4uckB-3qveA:undetectable","4uckB-3qveA:15.38"],["5NNA_A_BZMA301_0","ISATIN HYDROLASE A","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",6,"TRP A 212;VAL A 333;GLY A 261;GLY A 285;TYR A 257;HIS A 213","None;EDO A  13 ( 4.6A);EDO A  13 (-4.4A);EDO A  13 (-3.6A);None;None","1.25A","5nnaA-3qveA:undetectable","5nnaA-3qveA:17.36"],["5NNA_B_BZMB301_0","ISATIN HYDROLASE A","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",6,"TRP A 212;VAL A 333;GLY A 261;GLY A 285;TYR A 257;HIS A 213","None;EDO A  13 ( 4.6A);EDO A  13 (-4.4A);EDO A  13 (-3.6A);None;None","1.24A","5nnaB-3qveA:undetectable","5nnaB-3qveA:17.36"],["5NNA_C_BZMC301_0","ISATIN HYDROLASE A","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",6,"TRP A 212;VAL A 333;GLY A 261;GLY A 285;TYR A 257;HIS A 213","None;EDO A  13 ( 4.6A);EDO A  13 (-4.4A);EDO A  13 (-3.6A);None;None","1.25A","5nnaC-3qveA:undetectable","5nnaC-3qveA:17.36"],["5NNA_D_BZMD301_0","ISATIN HYDROLASE A","3qve","HMG BOX-CONTAINING PROTEIN 1","Homo sapiens",6,"TRP A 212;VAL A 333;GLY A 261;GLY A 285;TYR A 257;HIS A 213","None;EDO A  13 ( 4.6A);EDO A  13 (-4.4A);EDO A  13 (-3.6A);None;None","1.26A","5nnaD-3qveA:undetectable","5nnaD-3qveA:17.36"]]