SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 11 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.41A 1lwcA-3qviA:
undetectable		 1lwcA-3qviA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 TYR A  56
GLY A  21
ASP A  22
ASN A  23
 TYR  A  56 ( 1.3A)
GLY  A  21 ( 0.0A)
ASP  A  22 ( 0.5A)
ASN  A  23 ( 0.6A)
 1.15A 2g72A-3qviA:
undetectable		 2g72A-3qviA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 10 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.44A 2hndA-3qviA:
undetectable		 2hndA-3qviA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 10 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.44A 2hnyA-3qviA:
undetectable		 2hnyA-3qviA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 SER A  42
LYS A  44
SER A  85
SER A  58
 SER  A  42 ( 0.0A)
LYS  A  44 ( 0.0A)
SER  A  85 ( 0.0A)
SER  A  58 ( 0.0A)
 1.11A 2j9cA-3qviA:
undetectable
2j9cB-3qviA:
undetectable
2j9cC-3qviA:
undetectable		 2j9cA-3qviA:
14.74
2j9cB-3qviA:
14.74
2j9cC-3qviA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 SER A  85
SER A  58
SER A  42
LYS A  44
 SER  A  85 ( 0.0A)
SER  A  58 ( 0.0A)
SER  A  42 ( 0.0A)
LYS  A  44 ( 0.0A)
 1.15A 2j9cA-3qviA:
undetectable
2j9cB-3qviA:
undetectable
2j9cC-3qviA:
undetectable		 2j9cA-3qviA:
14.74
2j9cB-3qviA:
14.74
2j9cC-3qviA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 12 LEU A 140
PHE A  29
GLY A 122
ASN A  37
PHE A  27
 LEU  A 140 ( 0.6A)
PHE  A  29 ( 1.3A)
GLY  A 122 ( 0.0A)
ASN  A  37 ( 0.6A)
PHE  A  27 ( 1.3A)
 1.40A 2zznB-3qviA:
undetectable		 2zznB-3qviA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 ASP A 134
ASP A 127
LEU A 188
HIS A 186
 ASP  A 134 ( 0.6A)
ASP  A 127 ( 0.6A)
LEU  A 188 ( 0.5A)
HIS  A 186 ( 1.0A)
 0.78A 3bj8C-3qviA:
undetectable
3bj8D-3qviA:
undetectable		 3bj8C-3qviA:
17.18
3bj8D-3qviA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 ASP A  67
TYR A  99
TYR A  56
LEU A  20
 ASP  A  67 ( 0.6A)
TYR  A  99 ( 1.3A)
TYR  A  56 ( 1.3A)
LEU  A  20 ( 0.5A)
 1.20A 5bmvB-3qviA:
undetectable		 5bmvB-3qviA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 5 VAL A 197
VAL A 205
GLY A 201
PHE A 227
 VAL  A 197 ( 0.5A)
VAL  A 205 ( 0.6A)
GLY  A 201 ( 0.0A)
PHE  A 227 ( 1.4A)
 0.92A 5d4nA-3qviA:
undetectable
5d4nC-3qviA:
undetectable		 5d4nA-3qviA:
12.42
5d4nC-3qviA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		3 / 3 ASP A  68
SER A  58
TYR A  64
 ASP  A  68 ( 0.5A)
SER  A  58 ( 0.0A)
TYR  A  64 ( 1.3A)
 0.66A 5glmA-3qviA:
undetectable		 5glmA-3qviA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 TYR A 151
TYR A 313
ASP A 316
HIS A 318
 TYR  A 151 ( 1.3A)
TYR  A 313 ( 1.3A)
ASP  A 316 ( 0.6A)
HIS  A 318 ( 1.0A)
 1.48A 5ov9B-3qviA:
undetectable		 5ov9B-3qviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		3 / 3 LEU A 128
ASN A 211
LEU A 184
 LEU  A 128 (-0.6A)
ASN  A 211 ( 0.6A)
LEU  A 184 ( 0.5A)
 0.72A 6exiD-3qviA:
undetectable		 6exiD-3qviA:
10.64