SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 ILE A 101
ALA A 114
ILE A 243
PRO A 244
ASN A 245
 None
 1.16A 1dlsA-3qvmA:
undetectable		 1dlsA-3qvmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 9 LEU A 181
ILE A 182
ARG A  44
GLY A 187
ALA A 169
 SO4  A 283 (-4.4A)
None
SO4  A 284 (-3.6A)
None
None
 1.07A 1e7aA-3qvmA:
undetectable		 1e7aA-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		6 / 12 LEU A 168
HIS A 104
HIS A 256
ASP A 228
GLY A 255
PHE A 205
 None
 1.38A 1zz1B-3qvmA:
undetectable
1zz1C-3qvmA:
undetectable		 1zz1B-3qvmA:
21.49
1zz1C-3qvmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 CYH A  38
PHE A 189
LEU A 168
LEU A 171
LEU A 230
 None
 1.22A 2bxfA-3qvmA:
undetectable		 2bxfA-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 LEU A  31
VAL A 118
ALA A 114
LEU A  91
VAL A  92
 None
 1.13A 2c12C-3qvmA:
undetectable		 2c12C-3qvmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3qvm OLEI00960
(Oleispira
antarctica) 		3 / 3 VAL A  92
GLU A  88
GLU A  89
 None
 0.78A 2nv4A-3qvmA:
undetectable		 2nv4A-3qvmA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 ILE A 101
ALA A 114
ILE A 243
PRO A 244
ASN A 245
 None
 1.16A 2w3bB-3qvmA:
undetectable		 2w3bB-3qvmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3qvm OLEI00960
(Oleispira
antarctica) 		3 / 3 SER A 131
HIS A  34
ASP A  86
 None
 0.54A 2wa2B-3qvmA:
undetectable		 2wa2B-3qvmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 7 TYR A  77
VAL A  87
TYR A  61
ILE A 113
 None
 1.30A 2xz5B-3qvmA:
undetectable
2xz5E-3qvmA:
undetectable		 2xz5B-3qvmA:
22.18
2xz5E-3qvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 7 VAL A  87
TYR A  83
TYR A  61
ILE A 113
 None
 1.34A 2xz5B-3qvmA:
undetectable
2xz5E-3qvmA:
undetectable		 2xz5B-3qvmA:
22.18
2xz5E-3qvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 7 ILE A 113
TYR A  77
VAL A  87
TYR A  61
 None
 1.35A 2xz5D-3qvmA:
undetectable
2xz5E-3qvmA:
undetectable		 2xz5D-3qvmA:
22.18
2xz5E-3qvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 7 ILE A  90
LEU A  31
ALA A 114
ALA A 111
 None
 0.84A 3r9tB-3qvmA:
2.3		 3r9tB-3qvmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 9 VAL A  87
VAL A  99
ILE A 101
GLY A 103
SER A 107
 None
 1.24A 4fwdA-3qvmA:
undetectable		 4fwdA-3qvmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 8 LEU A 171
SER A 105
VAL A 142
GLY A 143
 None
 0.95A 4klrB-3qvmA:
2.0		 4klrB-3qvmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 10 ASP A  86
TYR A  61
SER A  67
HIS A 104
GLY A  35
 None
 1.38A 4lb9A-3qvmA:
0.8		 4lb9A-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3qvm OLEI00960
(Oleispira
antarctica) 		3 / 3 ARG A  76
GLU A  88
ARG A  17
 None
 0.99A 4mwvA-3qvmA:
undetectable		 4mwvA-3qvmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 TYR A  61
ASN A  18
ALA A  84
GLY A  82
ILE A 109
 None
 1.25A 4obwA-3qvmA:
3.2		 4obwA-3qvmA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 9 ILE A 113
GLY A  82
TYR A  61
ILE A 110
ALA A 111
 None
 1.02A 4yp2B-3qvmA:
undetectable		 4yp2B-3qvmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 ASP A  60
GLY A  63
THR A 192
SER A  71
TYR A  77
 None
 1.29A 5hfjH-3qvmA:
undetectable		 5hfjH-3qvmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 7 LEU A  31
VAL A  56
GLU A  51
ILE A 128
 None
 0.81A 5jh7C-3qvmA:
undetectable		 5jh7C-3qvmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3qvm OLEI00960
(Oleispira
antarctica) 		4 / 6 GLU A  81
ALA A  84
LEU A  80
TYR A 209
 None
 1.13A 5phhA-3qvmA:
undetectable		 5phhA-3qvmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 SER A 131
ILE A 109
LEU A 171
PHE A 205
LEU A 153
 None
 1.19A 6a93A-3qvmA:
undetectable		 6a93A-3qvmA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 PHE A  36
VAL A 106
PHE A 134
PHE A 145
TRP A 164
 None
 0.84A 6ap6A-3qvmA:
37.8		 6ap6A-3qvmA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3qvm OLEI00960
(Oleispira
antarctica) 		5 / 12 ILE A 251
ASP A 262
GLY A 264
ILE A 128
LEU A 270
 None
 1.07A 6dwnC-3qvmA:
undetectable		 6dwnC-3qvmA:
13.07