SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3qvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 ASN A  19
ALA A  22
LEU A  31
ALA A  33
ILE A  39
 None
 1.02A 1fk6A-3qvoA:
undetectable		 1fk6A-3qvoA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		4 / 7 GLN A  82
ASP A  78
SER A  85
ASN A  84
 None
 1.16A 1ig3A-3qvoA:
3.3
1ig3B-3qvoA:
3.2		 1ig3A-3qvoA:
24.32
1ig3B-3qvoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 LEU A  31
LEU A  74
VAL A 101
TYR A  71
ILE A  39
 None
 1.12A 1s9pA-3qvoA:
undetectable		 1s9pA-3qvoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 PHE A 129
ASP A  80
SER A 139
LEU A 141
ILE A  87
 None
 1.08A 1ynnC-3qvoA:
undetectable		 1ynnC-3qvoA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 GLY A   8
GLY A  10
VAL A  54
ASN A  73
LEU A  74
 None
 0.70A 1zq9B-3qvoA:
6.0		 1zq9B-3qvoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 10 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.20A 2riwA-3qvoA:
undetectable
2riwB-3qvoA:
undetectable		 2riwA-3qvoA:
20.80
2riwB-3qvoA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 10 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.15A 2xn6A-3qvoA:
undetectable
2xn6B-3qvoA:
undetectable		 2xn6A-3qvoA:
22.19
2xn6B-3qvoA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 ASP A 184
ILE A 182
TYR A  71
VAL A  17
TYR A 159
 None
 1.35A 3a8iA-3qvoA:
undetectable		 3a8iA-3qvoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 12 GLY A  11
GLY A  10
GLN A  12
LEU A 151
ILE A  18
 None
 1.22A 3h52B-3qvoA:
undetectable		 3h52B-3qvoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 11 THR A 204
ASP A 184
ALA A 180
ASP A 158
ILE A 157
 None
 1.27A 3id5B-3qvoA:
7.5		 3id5B-3qvoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 11 THR A 204
ASP A 184
ALA A 180
ASP A 158
ILE A 157
 None
 1.27A 3id5F-3qvoA:
7.6		 3id5F-3qvoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 10 LEU A 151
VAL A 178
ILE A 182
TYR A  71
ILE A   6
 None
 1.31A 3kz7A-3qvoA:
undetectable		 3kz7A-3qvoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 9 TYR A  71
ILE A 185
VAL A 178
ILE A 197
ILE A 199
 None
 1.27A 3p4wB-3qvoA:
undetectable		 3p4wB-3qvoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		4 / 6 PRO A 202
VAL A 178
THR A 171
THR A 204
 None
 0.98A 3tneA-3qvoA:
undetectable		 3tneA-3qvoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		3 / 3 ASP A  78
ARG A 131
PRO A 128
 None
 0.95A 4wanC-3qvoA:
undetectable		 4wanC-3qvoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3qvo NMRA FAMILY PROTEIN
(Shigella
flexneri) 		5 / 9 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.22A 4x30A-3qvoA:
undetectable		 4x30A-3qvoA:
20.19